New antibody drug aims to cut dangerous lung Flare-Ups in bronchiectasis patients

NCT ID NCT07088926

Recruiting now Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jan 11, 2026 · Last updated May 05, 2026 · Updated 14 times

Summary

This study tests an experimental drug called AZD0292 in people aged 12 and older who have bronchiectasis and a chronic lung infection with Pseudomonas aeruginosa. The goal is to see if the drug can reduce the number of moderate-to-severe lung flare-ups compared to a placebo. About 435 participants will receive either the drug or a placebo by IV, and researchers will track flare-ups and quality of life over time.

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Contacts and locations

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Study contacts

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Locations

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Orange, California, 92868, United States
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San Francisco, California, 94143, United States
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Denver, Colorado, 80206, United States
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Washington D.C., District of Columbia, 20007, United States
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Jacksonville, Florida, 32209, United States
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SUSPENDED

Miami Lakes, Florida, 33014, United States
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Naples, Florida, 34102, United States
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Ormond Beach, Florida, 32174, United States
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Plantation, Florida, 33324, United States
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Rincon, Georgia, 31326, United States
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Kansas City, Kansas, 66160, United States
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Ann Arbor, Michigan, 48109, United States
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Rochester, Minnesota, 55905, United States
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St Louis, Missouri, 63130, United States
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New York, New York, 10016, United States
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New Bern, North Carolina, 28562, United States
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Winston-Salem, North Carolina, 27104, United States
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Tulsa, Oklahoma, 74133, United States
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DuBois, Pennsylvania, 15801, United States
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Philadelphia, Pennsylvania, 19104, United States
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Charleston, South Carolina, 29425, United States
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Rock Hill, South Carolina, 29732, United States
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Austin, Texas, 78705, United States
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Mansfield, Texas, 76063, United States
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Ciudad de Buenos Aires, C1180AAX, Argentina
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Florida, B1602DQD, Argentina
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Rosario, 2000, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Birtinya, 4575, Australia
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Macquarie University, 2109, Australia
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South Brisbane, 4101, Australia
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Sint-Niklaas, 9100, Belgium
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Blumenau, 89030-101, Brazil
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Campinas, 13060-080, Brazil
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Curitiba, 80030-110, Brazil
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Curitiba, 80230-130, Brazil
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Porto Alegre, 9061-000, Brazil
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Porto Alegre, 90630-165, Brazil
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Porto Alegre, 91350-200, Brazil
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Salvador, 40050-410, Brazil
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São José dos Campos, 12230-001, Brazil
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São Paulo, 05.403-010, Brazil
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São Paulo, 05403-000, Brazil
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Calgary, Alberta, T2N4Z6, Canada
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Vancouver, British Columbia, V5Z 1M9, Canada
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Ajax, Ontario, L1S 2J5, Canada
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Stoney Creek, Ontario, L8G 2V6, Canada
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Québec, Quebec, G1V 4G5, Canada
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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada
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Trois-Rivières, Quebec, G8T 7A1, Canada
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Concepción, 4070196, Chile
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Santiago, 8150000, Chile
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Santiago, 8380453, Chile
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Talca, 3481349, Chile
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Viña del Mar, 2540364, Chile
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Aalborg, 9000, Denmark
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Aarhus N, 8200, Denmark
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Hvidovre, 2650, Denmark
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Odense C, 5000, Denmark
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Roskilde, 4000, Denmark
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Brest, 29200, France
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Créteil, 94010, France
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Marseille, 13915, France
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Montpellier, 34295, France
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Paris, 75014, France
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Pessac, 33604, France
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Strasbourg, 67091, France
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Toulouse, 31100, France
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Darmstadt, 64283, Germany
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Essen, 45239, Germany
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Frankfurt, 60596, Germany
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Halle, 06108, Germany
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Hanover, 30625, Germany
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Konstanz, 78464, Germany
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München, 80336, Germany
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München-Pasing, 81241, Germany
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Athens, 11527, Greece
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Athens, 12462, Greece
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Athens, 15126, Greece
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Athens, 17562, Greece
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Ioannina, 45500, Greece
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Larissa, 41110, Greece
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Pátrai, 26500, Greece
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Thessaloniki, 57010, Greece
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Ashkelon, 7830604, Israel
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Haifa, 34362, Israel
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Jerusalem, 00000, Israel
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Jerusalem, 91031, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 6423906, Israel
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Milan, 20122, Italy
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Palermo, 90127, Italy
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Pavia, 27100, Italy
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Perugia, 06129, Italy
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Roma, 00163, Italy
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Rozzano, 20089, Italy
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Torrette, 60126, Italy
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Bunkyō City, 113-8655, Japan
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Gifu, 500-8717, Japan
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Hiratsuka-shi, 254-8502, Japan
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Kamogawa-shi, 296-0041, Japan
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Kiyose-shi, 204-8522, Japan
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Kiyose-shi, 204-8585, Japan
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Kurashiki-shi, 710-8602, Japan
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Miyazaki, 889-1692, Japan
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Nagasaki, 852-8501, Japan
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Ogi, 845-0032, Japan
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Shinjuku-ku, 160-8582, Japan
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Shinjuku-ku, 162-8655, Japan
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Urayasu-shi, 279-0021, Japan
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Bandar Puncak Alam, 42300, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Sibu, 96000, Malaysia
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Amsterdam, 1081 HV, Netherlands
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Rotterdam, 3015 GD, Netherlands
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Zutphens, 7207 AE, Netherlands
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Bellavista, CALLAO 2, Peru
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Lima, 15023, Peru
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Lima, 15036, Peru
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Lima, 15038, Peru
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Lima, 15082, Peru
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Lima, 15088, Peru
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Lima, LIMA 1, Peru
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Lima, LIMA 29, Peru
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Iloilo City, 5000, Philippines
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Manila, 1000, Philippines
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Quezon City, 1100, Philippines
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Tondo, 1012, Philippines
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Anyang-si, 14068, South Korea
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Cheongju-si, 28644, South Korea
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Daegu, 42415, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 04763, South Korea
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Seoul, 05030, South Korea
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Seoul, 05505, South Korea
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Seoul, 07441, South Korea
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Ulsan, 44033, South Korea
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Barcelona, 08003, Spain
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Barcelona, 08036, Spain
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Benalmádena, 29631, Spain
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Madrid, 28040, Spain
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Madrid, 28046, Spain
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Mérida, 06800, Spain
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Patraix, 46017, Spain
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Valencia, 46009, Spain
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Kaohsiung City, 80756, Taiwan
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Taichung, 40447, Taiwan
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Taichung, 40705, Taiwan
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Taipei, 0116, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 110, Taiwan
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Taoyuan, 333, Taiwan
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Bang Kra So, 11000, Thailand
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Bangkok, 10400, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 50200, Thailand
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Pathum Thani, 12120, Thailand
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Adana, 1330, Turkey (Türkiye)
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Ankara, 6340, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34890, Turkey (Türkiye)
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Mersin, 33343, Turkey (Türkiye)
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Zeytinburnu, 34020, Turkey (Türkiye)
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Belfast, BT9 7AB, United Kingdom
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Birmingham, B9 5SS, United Kingdom
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Brighton, BN2 1ES, United Kingdom
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Cambridge, CB2 0AY, United Kingdom
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Dundee, DD1 9SY, United Kingdom
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Edinburgh, EH16 4SA, United Kingdom
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Exeter, EX2 5DW, United Kingdom
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Liverpool, L14 3PE, United Kingdom
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Manchester, M23 9LT, United Kingdom
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Can Tho, 900000, Vietnam
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Haiphong, 180000, Vietnam
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Hanoi, 100000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Huế, 530000, Vietnam

Conditions

Explore the condition pages connected to this study.

BRONCHIECTASIS WITH PSEUDOMONAS AERUGINOSA COLONIZATION