Foam plug could open door to lung valve therapy for thousands

NCT ID NCT06035120

Recruiting now Disease control Sponsor: Pulmonx Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a foam called AeriSeal that is squirted into damaged parts of the lung to block tiny air leaks. After the foam, doctors check if the lung is now sealed enough to place a one-way valve that lets trapped air escape. The goal is to help people with severe emphysema breathe easier. About 200 participants will be followed for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AeriSeal Foam (a foam delivered via bronchoscope to block collateral ventilation in the lung)
What this could lead to: If it works, this could allow more people with severe emphysema to get lung volume reduction with valves, improving breathing and quality of life.
What could go wrong: This is an early-stage, single-arm study with no placebo group, so results may not be definitive. The foam and valve procedure carry risks like infection, air leaks, or worsening breathing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMPHYSEMA OR COPD EMPHYSEMA, PULMONARY

Contacts and locations

Locations

ASST Spedali Civili, University Hospital
RECRUITING

Brescia, Italy, Italy
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Asklepios Klinik Barmbek
RECRUITING

Hamburg, Germany, Germany
Banner University Medical Center
RECRUITING

Phoenix, Arizona, 85006, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02115, United States
Brigham Lung Center
WITHDRAWN

Boston, Massachusetts, 02115, United States
CHRU Strasbourg
RECRUITING

Strasbourg, France, France
CHU Limoges
RECRUITING

Limoges, France, France
CHU Toulouse
RECRUITING

Toulouse, France, France
Cleveland VA Northeast
WITHDRAWN

Cleveland, Ohio, 44106, United States
Fort Sanders Regional Medical Center (StatCare)
RECRUITING

Knoxville, Tennessee, 37916, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Hopital Bichat-APHP
RECRUITING

Paris, France, France
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, Spain, Spain
Inova Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Klinik Floridsdorf
RECRUITING

Vienna, Austria, Austria
Lungenklinik Hemer
RECRUITING

Hemer, Germany, Germany
Macquarie University
RECRUITING

Macquarie Park, Australia, Australia
Medical College of Wisconsin (MCW)
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
OSF Saint Francis Medical Center
RECRUITING

Peoria, Illinois, 61606, United States
Orlando Health
RECRUITING

Orlando, Florida, 32806, United States
Penn Medicine
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Rigshospitalet
WITHDRAWN

Copenhagen, Denmark, Denmark
Royal Adelaide Hospital
RECRUITING

Adelaide, Australia, Australia
Royal Brompton Hospital
RECRUITING

London, England, United Kingdom
Ruhrlandklink, Uni Essen
RECRUITING

Essen, Germany, Germany
Saint Francis Hospital and Medical Center (Trinity Health of New England)
RECRUITING

Hartford, Connecticut, 06105, United States
Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
Thoraxklinik am Universitats klinikum Heidelberg
RECRUITING

Heidelberg, Germany, Germany
University Medical Center Groningen
RECRUITING

Groningen, Netherlands, Netherlands
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Pittsburgh Medical Center (UPMC)
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75235, United States
Universitätsklinikum Halle
RECRUITING

Halle, Germany, Germany
Wesley Hospital
RECRUITING

Brisbane, Australia, Australia

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