Foam plug could open door to lung valve therapy for thousands
NCT ID NCT06035120
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a foam called AeriSeal that is squirted into damaged parts of the lung to block tiny air leaks. After the foam, doctors check if the lung is now sealed enough to place a one-way valve that lets trapped air escape. The goal is to help people with severe emphysema breathe easier. About 200 participants will be followed for two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AeriSeal Foam (a foam delivered via bronchoscope to block collateral ventilation in the lung)
What this could lead to
If it works, this could allow more people with severe emphysema to get lung volume reduction with valves, improving breathing and quality of life.
What could go wrong
This is an early-stage, single-arm study with no placebo group, so results may not be definitive. The foam and valve procedure carry risks like infection, air leaks, or worsening breathing.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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ASST Spedali Civili, University Hospital
RECRUITINGBrescia, Italy, Italy
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Asklepios Klinik Barmbek
RECRUITINGHamburg, Germany, Germany
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Banner University Medical Center
RECRUITINGPhoenix, Arizona, 85006, United States
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02115, United States
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Brigham Lung Center
WITHDRAWNBoston, Massachusetts, 02115, United States
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CHRU Strasbourg
RECRUITINGStrasbourg, France, France
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CHU Limoges
RECRUITINGLimoges, France, France
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CHU Toulouse
RECRUITINGToulouse, France, France
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Cleveland VA Northeast
WITHDRAWNCleveland, Ohio, 44106, United States
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Fort Sanders Regional Medical Center (StatCare)
RECRUITINGKnoxville, Tennessee, 37916, United States
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
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Hopital Bichat-APHP
RECRUITINGParis, France, France
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Hospital Universitario y Politecnico La Fe
RECRUITINGValencia, Spain, Spain
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Inova Fairfax Hospital
RECRUITINGFalls Church, Virginia, 22042, United States
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Klinik Floridsdorf
RECRUITINGVienna, Austria, Austria
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Lungenklinik Hemer
RECRUITINGHemer, Germany, Germany
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Macquarie University
RECRUITINGMacquarie Park, Australia, Australia
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Medical College of Wisconsin (MCW)
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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OSF Saint Francis Medical Center
RECRUITINGPeoria, Illinois, 61606, United States
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Orlando Health
RECRUITINGOrlando, Florida, 32806, United States
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Penn Medicine
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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Rigshospitalet
WITHDRAWNCopenhagen, Denmark, Denmark
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Royal Adelaide Hospital
RECRUITINGAdelaide, Australia, Australia
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Royal Brompton Hospital
RECRUITINGLondon, England, United Kingdom
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Ruhrlandklink, Uni Essen
RECRUITINGEssen, Germany, Germany
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Saint Francis Hospital and Medical Center (Trinity Health of New England)
RECRUITINGHartford, Connecticut, 06105, United States
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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Thoraxklinik am Universitats klinikum Heidelberg
RECRUITINGHeidelberg, Germany, Germany
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University Medical Center Groningen
RECRUITINGGroningen, Netherlands, Netherlands
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
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University of Pittsburgh Medical Center (UPMC)
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75235, United States
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Universitätsklinikum Halle
RECRUITINGHalle, Germany, Germany
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Wesley Hospital
RECRUITINGBrisbane, Australia, Australia
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