New lung implant aims to release trapped air in emphysema patients

NCT ID NCT05949645

Ongoing Disease control Sponsor: Apreo Health, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a new device called the Apreo Implant, which is placed in the airways during a bronchoscopy to release trapped air in severely overinflated lungs. Up to 30 people with severe emphysema will receive up to two procedures, with follow-up for one year. The main goals are to see if the procedure is safe and if it improves breathing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Apreo Implant (a device placed in the airways to release trapped air)
What this could lead to: If it works, this could offer a new, less invasive option to help people with severe emphysema breathe easier and feel better.
What could go wrong: This is a small, early feasibility study with only 30 participants, so results may not apply to everyone. The implant procedure carries risks like any bronchoscopy, including infection or lung injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMPHYSEMA OR COPD

Contacts and locations

Locations

Karl Landsteiner Institute, Klinik Floridsdorf

Sankt Pölten, Austria
Royal Brompton Hospital

London, United Kingdom
University Medical Center Groningen

Groningen, GZ, 9713, Netherlands

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