Lung valve registry shows promise for emphysema patients

NCT ID NCT04517916

Completed Disease control Sponsor: Pulmonx Corporation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed French registry tracked 155 adults with severe emphysema or COPD who received Zephyr Valves, tiny devices placed in the lungs to help them work better. The goal was to see if the treatment safely improves breathing over 12 months. Researchers measured lung function and used CT scans to check for lung volume reduction.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zephyr Valve (a device placed in the lungs to reduce air trapping)
What this could lead to: If results are positive, this could support continued use of the Zephyr Valve as a safe and effective treatment for severe emphysema/COPD.
What could go wrong: This is an observational registry, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients, and risks like infection or valve movement exist.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMPHYSEMA OR COPD

Contacts and locations

Locations

Hôpital Arnaud de Villeneuve

Montpellier, France
Hôpital Bichat

Paris, France
Hôpital Calmette

Lille, France
Hôpital Charles Nicolle

Rouen, France
Hôpital Cochin

Paris, France
Hôpital Dupuytren

Limoges, France
Hôpital François Mitterrand

Dijon, France
Hôpital La Cavale Blanche

Brest, France
Hôpital Larrey

Toulouse, France
Hôpital Nord

Latronche, France
Hôpital Nord

Saint-Etienne, France
Nouvel Hôpital Civil

Strasbourg, France

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