New drug aims to cut COPD attacks in patients with specific inflammation

NCT ID NCT07177339

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This study tests whether adding depemokimab early to standard COPD treatment can reduce moderate to severe flare-ups in people with moderate to severe COPD who have type 2 inflammation. About 1,200 participants will receive either depemokimab or a placebo as an add-on therapy. The main goal is to see if the drug lowers the yearly rate of flare-ups requiring steroids, antibiotics, or hospitalization.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY DISEASE, CHRONIC OBSTRUCTIVE

Contacts and locations

Locations

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Newport Beach, California, 92663, United States
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Lakewood, Colorado, 80228-1813, United States
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Brandon, Florida, 33511, United States
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Crystal River, Florida, 34429, United States
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Doral, Florida, 33172, United States
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Greenacres City, Florida, 33467, United States
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Hialeah, Florida, 33012, United States
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Hollywood, Florida, 33024, United States
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Miami, Florida, 33125, United States
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Miami, Florida, 33126, United States
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Miami, Florida, 33176, United States
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Miami Lakes, Florida, 33016, United States
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Orlando, Florida, 32825, United States
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Cordele, Georgia, 31015, United States
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Dunwoody, Georgia, 30350, United States
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Boise, Idaho, 83702, United States
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Bowling Green, Kentucky, 42101, United States
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Lake Charles, Louisiana, 70605, United States
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Shreveport, Louisiana, 71105, United States
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Bangor, Maine, 04401, United States
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Allen Park, Michigan, 48101, United States
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Clarkston, Michigan, 48346, United States
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Dearborn, Michigan, 48126, United States
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Henderson, Nevada, 89052, United States
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Las Vegas, Nevada, 89123, United States
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Reno, Nevada, 89502, United States
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Winston-Salem, North Carolina, 27103, United States
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Edmond, Oklahoma, 73013, United States
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DuBois, Pennsylvania, 15801, United States
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West Chester, Pennsylvania, 19380, United States
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Greenville, South Carolina, 29607, United States
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Rock Hill, South Carolina, 29732, United States
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Knoxville, Tennessee, 37919, United States
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Dallas, Texas, 75254, United States
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DeSoto, Texas, 75115, United States
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Greenville, Texas, 75401, United States
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Houston, Texas, 77058, United States
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Houston, Texas, 77089, United States
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Houston, Texas, 77090, United States
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Katy, Texas, 77494, United States
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Mesquite, Texas, 75149, United States
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Stafford, Texas, 77477, United States
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Coffs Harbour, New South Wales, 2450, Australia
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Spearwood, Western Australia, 6163, Australia
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Haskovo, 6300, Bulgaria
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Montana, 3400, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1463, Bulgaria
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Sofia, 1510, Bulgaria
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Sofia, 1756, Bulgaria
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Kingston, Ontario, K7M 7E4, Canada
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Windsor, Ontario, N8X 1T3, Canada
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Shapingba, Chongqing Municipality, China
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Nanning, Guangxi, 530016, China
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Chengdu, Sichuan, 610500, China
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Chengdu, Sichuan, China
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Suining, Sichuan, 629018, China
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Beijing, 100020, China
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Beijing, 100034, China
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Changchun, 130021, China
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Changchun, 130041, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400042, China
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Dongguan, 523326, China
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Fujian, 350001, China
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Guangzhou, 510080, China
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Guangzhou, 510150, China
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Guangzhou, 510180, China
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Guilin, 541002, China
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Haikou, 570001, China
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Hangzhou, 310000, China
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Harbin, 150001, China
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Hefei, 230001, China
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Hohhot, 010050, China
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Huizhou, 516000, China
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Jiangmen, 529100, China
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Jiangmen, 529700, China
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Jinzhou, 121000, China
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Nanchang, 330000, China
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Nanchang, 330006, China
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Nanjing, 210009, China
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Qinhuangdao, 66000, China
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Shanghai, 200032, China
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Shanghai, 201199, China
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Shijiazhuang, 050000, China
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Shijiazhuang, 050051, China
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Taiyuan, 030001, China
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Taizhou, 317000, China
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Taizhou, 318000, China
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Ürümqi, 830054, China
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Weifang, China
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Wenzhou, 325000, China
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Xiamen, 361004, China
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Xinxiang, 453000, China
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Yinchuan, 750001, China
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Zunyi, 563114, China
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Berlin, 10625, Germany
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Berlin, 10717, Germany
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Frankfurt, 60389, Germany
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Frankfurt, 60596, Germany
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Mainz, 60549, Germany
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München, 81241, Germany
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Palaió Fáliro, Anatoliki Attiki, 175 62, Greece
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Ioannina, 45500, Greece
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Thessaloniki, Greece
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Ramat Gan, 52621, Israel
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Tel Aviv, 64239, Israel
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Gifu, 509-6134, Japan
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Mie, 515-8544, Japan
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Tokyo, 140-8522, Japan
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Ebdentown, Upper Hutt, 5018, New Zealand
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Rotorua, 3010, New Zealand
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Bialystok, 15-044, Poland
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Rzeszów, 35-051, Poland
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Barcelona, Spain
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Málaga, 29010, Spain
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Palma de Mallorca, 07010, Spain
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Bedford, MK40 2FG, United Kingdom
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Bradford, BD9 6RJ, United Kingdom
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Corby, NN17 2UR, United Kingdom

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