Can a new injection ease COPD and cut Flare-Ups?

NCT ID NCT07759245

Not yet recruiting Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the number of COPD flare-ups compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brenipatide (an investigational drug given by injection)
What this could lead to: If successful, brenipatide could offer a new way to improve breathing and reduce COPD flare-ups, potentially adding a much-needed treatment option for people with moderate-to-severe disease.
What could go wrong: This is an early-stage (phase 2) trial, so the drug may not prove more effective than placebo. Possible side effects are still being evaluated, and results may not apply to all COPD patients.

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Conditions

The condition(s) this trial relates to.

chronic bronchitis chronic obstructive pulmonary disease COPD, severe early onset lung disorder pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY DISEASE, CHRONIC OBSTRUCTIVE

Contacts and locations

Locations

Aalborg Universitetshospital, Syd

Aalborg, 9000, Denmark
Aarhus Universitetshospital, Skejby

Aarhus, 8200, Denmark
All India Institute of Medical Sciences

New Delhi, 110029, India
Anima Speciality Medical Services

Bucharest, 061696, Romania
Arensia Clinics S.R.L.

Bucharest, 011658, Romania
Asan Medical Center

Seoul, 05505, South Korea
Asklepios MVZ Bayern

Landsberg am Lech, 86899, Germany
Aso Iizuka Hospital

Iizuka, 820-8505, Japan
Atlantic Medical

Penzance, TR18 3DX, United Kingdom
Axis Clinical Trials - Westchester

Westchester, Illinois, 60154, United States
BRCR Global Puerto Rico

San Juan, 00907-1509, Puerto Rico
Baylor College of Medicine Medical Center

Houston, Texas, 77030, United States
Bispebjerg Hospital

Copenhagen, 2400, Denmark
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Budapesti Uzsoki Utcai Kórház

Budapest, 1145, Hungary
Bugbox & Med

Budapest, 1203, Hungary
C.I.C. Mauricie inc.

Trois-Rivières, G8T 7A1, Canada
CCR Ostrava s.r.o

Ostrava, 702 00, Czechia
CHRU de Brest

Brest, 29609, France
CHU Bordeaux Haut-Leveque

Pessac, 33600, France
CHU de Toulouse - Hopital Larrey

Toulouse, 31059, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois

Vandœuvre-lès-Nancy, 54511, France
Centre Hospitalier de Cholet

Cholet, 49325, France
Centro Médico Viamonte

Buenos Aires, C1120AAC, Argentina
Centro de Salud e Investigaciones Médicas

Santa Rosa, L6300, Argentina
Centrum Medyczne ,,All - Med'' Badania Kliniczne

Krakow, 30-033, Poland
Cheadle Community Hospital

Cheadle, ST10 1NS, United Kingdom
China-Japan Friendship Hospital

Beijing, 100029, China
Chu Grenoble Alpes

La Tronche, 38700, France
Chung-Ang University Hospital

Dongjak-gu, 06973, South Korea
Clinical Research Associates of Central PA

DuBois, Pennsylvania, 15801, United States
Consultorios Médicos, Organización del Buen Ayre S.R.L.

Buenos Aires, 1425, Argentina
Delta Health Care

Bucharest, 014142, Romania
Deluxe Health Center

Miami Lakes, Florida, 33014, United States
Diamond Clinic

Krakow, 31-559, Poland
Diex Recherche Inc. Division Sherbrooke Est

Sherbrooke, J1L 0K3, Canada
Dr. Ram Manohar Lohia Institute of Medical Sciences

Lucknow, 226010, India
Dr. Syed Anees Medicine Professional Corporation

Windsor, N8X 1T3, Canada
Erzsebet Gondozohaz

Gödöllő, 2100, Hungary
Esbjerg sygehus, Syddansk Universitetshospital

Esbjerg, 6700, Denmark
Florida Institute For Clinical Research, LLC

Orlando, Florida, 32825, United States
Fundacion Scherbovsky

Mendoza, 5500, Argentina
Fundación Respirar

Buenos Aires, C1426ABP, Argentina
Galaxy Superspeciality Hospital

Aurangabad, 431001, India
HMC Health Group - Meadows Centre for Health

Hounslow, TW4 7NJ, United Kingdom
Headlands Research-Twin Cities

Maplewood, Minnesota, 55109, United States
Henri Mondor Hospital

Créteil, 94000, France
Hopitaux Universitaires Paris Centre-Hopital Cochin

Paris, 75679, France
Hvidovre Hospital

Hvidovre, 2650, Denmark
Hôpital Arnaud de Villeneuve - CHU Montpellier

Montpellier, 34090, France
Hôpital Européen Marseille

Marseille, 13003, France
Hôpital de la Croix Rousse

Lyon, 69004, France
IKF Pneumologie Frankfurt, Clinical Research Center, Departments: Pulmonology, Endocrinology, Cardiovascul -T

Frankfurt, 60596, Germany
IKF Pneumologie Mainz

Mainz, 55128, Germany
IU Health Ball Memorial Hospital, Inc.

Muncie, Indiana, 47303, United States
Indiana University Health University Hospital

Indianapolis, Indiana, 46202, United States
Infer-Med

Pécs, 7635, Hungary
Inspiration Research

Toronto, M5T 3A9, Canada
Institute of HealthCare Assessment d/b/a Apex Clinical Research

San Diego, California, 92120, United States
Instituto Médico Río Cuarto

Río Cuarto, X5800AEV, Argentina
Jiangyin People's Hospital

Jiangyin, 214400, China
Jinan Central Hospital

Jinan, 250013, China
Kelowna Health and Memory Centre

Kelowna, V1Y 5A8, Canada
Klinik Floridsdorf

Vienna, 1210, Austria
Klinikum Klagenfurt am Wörthersee

Klagenfurt, 9020, Austria
Koch Róbert Kórház és Rendelőintézet

Edelény, 3780, Hungary
Kohler & Milstein Research S.A. De C.V.

Mérida, 97070, Mexico
Konkuk University Medical Center

Seoul, 05030, South Korea
Kyushu Central Hospital

Fukuoka, 815-0032, Japan
Lifepoint Multispeciality Hospital

Pune, 411057, India
Lungenfachklinik Immenhausen

Immenhausen, 34376, Germany
ME Clinical Respiratory Research Hamburg

Hamburg, 22299, Germany
MEDITRIAL s.r.o.

Jindichv Hradec, 377 01, Czechia
Marine Lake Medical Practice

West Kirby, CH48 5AA, United Kingdom
Medimanage Research

Tlalpan, 14050, Mexico
Medstar Speciality Hospital

Bangalore, 560092, India
Millennium Medical Research - Miami

Miami, Florida, 33126, United States
Motilal Nehru Medical College Hospital

Allahābād, 211002, India
National Jewish Health Medical Center

Denver, Colorado, 80206, United States
NewportNativeMD, Inc.

Newport Beach, California, 92663, United States
Orchid Hospital - Pune

Pune, 411047, India
Ordinace chorob plicních

Prague, 110 00, Czechia
Ordination für Lungenkrankheiten

Linz, 4020, Austria
Osaka Keisatsu Hospital

Osaka, 543-0042, Japan
Pacific Medical College & Hospital

Udaipur, 313001, India
Paramount Clinical Research - Data Point Clinical Research

Kirkland, Washington, 98034, United States
Pingxiang People's Hospital

Pingxiang, 337055, China
Premier Pulmonary Critical Care and Sleep

Denison, Texas, 75020, United States
Prime Clinical Research - Lewisville

Lewisville, Texas, 75067, United States
Private Practice - Dr. Ilona Pavlišová

Miroslav, 671 72, Czechia
Private Practice - Dr. Marc Hoffgen, Dr. Olaf Kesterman, Dr. Frank Koesters & Dr. Steffen Bulicke

Rheine, 48431, Germany
Private Practice - Dr. Robert Voves

Feldbach, 8330, Austria
Queen Anne Street Medical Centre

London, W1T 6AH, United Kingdom
Revive Research Institute, Inc.

Southfield, Michigan, 48075, United States
Roskilde Sygehus

Roskilde, 4000, Denmark
Salvus - Klinische Studien GmbH

Leipzig, 04207, Germany
San Juan Bautista School of Medicine - Clinical Research Unit

Caguas, 00726, Puerto Rico
Scientia Investigacion Clinica S.C.

Chihuahua City, 31207, Mexico
Shanghai General Hospital

Shanghai, 200080, China
ShenZhen People's Hospital

Shenzhen, 518020, China
Sichuan Provincial People's Hospital

Chengdu, 610072, China
Silver Touch Hospital

Ahmedabad, 380015, India
Spital de Pneumologie Dr. Lavinia Davidescu

Oradea, 410063, Romania
Spitalul Clinic Judetean de Urgenta Cluj Napoca

Cluj-Napoca, 400006, Romania
Spitalul Clinic de Boli Infecţioase si Pneumoftiziologie Dr. Victor Babeş Timișoara

Timișoara, 300310, Romania
Spitalul Clinic de Pneumoftiziologie "Leon Daniello" Cluj

Cluj-Napoca, 400371, Romania
Spitalul de Boli Infecțioase Victor Babeș

Craiova, 200515, Romania
Staploe Medical Centre

Ely, CB7 5JD, United Kingdom
Studienzentrum Dr. Keller

Frankfurt, 60389, Germany
The Catholic Univ. of Korea Seoul St. Mary's Hospital

Seoul, 06591, South Korea
The Catholic University of Korea, Eunpyeong St. Mary's Hospital

Seoul, 03312, South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital

Bupyeong-gu, 21431, South Korea
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T

Baotou, 014010, China
The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, 510120, China
The First People's Hospital of Xinxiang

Xinxiang, 453000, China
The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, 710004, China
Tianjin Medical University General Hospital

Tianjin, 300052, China
Tohoku Medical and Pharmaceutical University Hospital

Sendai, 983-8512, Japan
Tokyo-Eki Center-building Clinic

Chūōku, 103-0027, Japan
Ulsan University Hospital

Ulsan, 44033, South Korea
Unidad Medica para la Salud Integral Interior A

San Nicolás de los Garza, 66465, Mexico
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
Uniwersytecki Szpital Kliniczny w Białymstoku

Bialystok, 15-276, Poland
Vejle Sygehus

Vejle, 7100, Denmark
Yamaguchi University Hospital

Ube, 755-8505, Japan
Yatharth Super Speciality Hospital - Noida Extension

Noida, 201306, India
Yeungnam Univeristy Medical Center

Gyeongsan-si, 42415, South Korea
Yonsei University-Wonju Severance Christian Hospital

Wŏnju, 26426, South Korea

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