New shot could reduce COPD Flare-Ups

NCT ID NCT07363694

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called PF-07275315 in adults with moderate-to-severe COPD who have had at least two flare-ups in the past year. Participants receive either the drug or a placebo as injections over several months. The goal is to see if the drug improves lung function and reduces the number of serious breathing attacks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

PF-07275315 (an experimental drug given as injections)

What this could lead to

If it works, this could provide a new treatment option to help people with COPD breathe easier and have fewer serious flare-ups.

What could go wrong

This is an early-to-mid stage trial, so the drug may not prove effective or safe. Side effects are possible, and results may not apply to all COPD patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATE TO SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AA Medical Research Center
RECRUITING

Flint, Michigan, 48504, United States
ASHA Clinical Research - Munster, LLC
RECRUITING

Hammond, Indiana, 46324, United States
Advanced Pulmonary Research Institute
RECRUITING

Loxahatchee Groves, Florida, 33470, United States
Alina Clinical Trials, LLC.
RECRUITING

Dallas, Texas, 75209, United States
Aso Iizuka Hospital
NOT_YET_RECRUITING

Iizuka-shi, Fukuoka, 820-8505, Japan
Barnes-Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Barnes-Jewish Hospital Investigational Drug Service
RECRUITING

St Louis, Missouri, 63110, United States
Bhaktivedanta Hospital and Research Institute
RECRUITING

Thane, Maharashtra, 401107, India
C.I.C. Mauricie inc.
NOT_YET_RECRUITING

Trois-Rivières, Quebec, G8T 7A1, Canada
California Medical Research Associates
RECRUITING

Northridge, California, 91324, United States
Centricity Research Rincon Pulmonology
RECRUITING

Rincon, Georgia, 31326, United States
Chandler Clinical Trials
NOT_YET_RECRUITING

Chandler, Arizona, 85224, United States
Chang Gung Medical Foundation-Linkou Branch
NOT_YET_RECRUITING

Taoyuan, 333, Taiwan
Chengdu Fifth People's Hospital
RECRUITING

Chengdu, Sichuan, 611130, China
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
China-Japan Friendship Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100029, China
Clinical Research Associates of Central PA, LLC
RECRUITING

DuBois, Pennsylvania, 15801, United States
Clinical Research Specialists LLC
NOT_YET_RECRUITING

Kissimmee, Florida, 34746, United States
Clinical Research of Rock Hill
RECRUITING

Rock Hill, South Carolina, 29732, United States
Clinical Site Partners, LLC dba Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
Clinical Trials Center of Middle Tennessee, LLC
RECRUITING

Franklin, Tennessee, 37067, United States
Coastal Medical Research Institute, LLC
RECRUITING

St. Petersburg, Florida, 33704, United States
Coastal Pulmonary and Critical Care, P.L.C
RECRUITING

St. Petersburg, Florida, 33704, United States
Cpcc-Research Llc
RECRUITING

East Point, Georgia, 30344, United States
Dr. Syed Anees Medicine Professional Corporation
RECRUITING

Windsor, Ontario, N8X 1T3, Canada
Far Eastern Memorial Hospital
NOT_YET_RECRUITING

New Taipei City, 220, Taiwan
Finlay Medical Research
RECRUITING

Greenacres City, Florida, 33467, United States
Fujieda Municipal General Hospital
NOT_YET_RECRUITING

Fujieda, Shizuoka, 426-0077, Japan
Greater Heights & Memorial Pulmonary and Sleep
RECRUITING

Houston, Texas, 77008, United States
HCA Florida Ocala Imaging Center
RECRUITING

Ocala, Florida, 34471, United States
Health Concepts
RECRUITING

Rapid City, South Dakota, 57702, United States
Henderson Clinical Trials
RECRUITING

Henderson, Nevada, 89052, United States
Hindusthan Hospital
NOT_YET_RECRUITING

Coimbatore, Tamil Nadu, 641028, India
Horizon Clinical Research Group
RECRUITING

Cypress, Texas, 77429, United States
Houston Pulmonary Sleep and Allergy Associates
RECRUITING

Houston, Texas, 77065, United States
IMAX Clinical Trials
RECRUITING

La Palma, California, 90623, United States
Institute of HealthCare Assessment d/b/a Apex Clinical Research
RECRUITING

San Diego, California, 92120, United States
Jawahar Lal Nehru Medical College
NOT_YET_RECRUITING

Ajmer, Rajasthan, 305001, India
Jeonbuk National University Hospital
RECRUITING

Jeonju, Jeonbuk-do, 54907, South Korea
KLES Dr. Prabhakar Kore Hospital and Medical Research Centre
RECRUITING

Belagavi, Karnataka, 590010, India
Kamineni Hospitals Private Limited
NOT_YET_RECRUITING

Hyderabad, Telangana, 500068, India
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Korea University Anam Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 02841, South Korea
Koujunkai Daido Clinic
NOT_YET_RECRUITING

Nagoya, Aichi-ken, 457-8511, Japan
Kure Kyosai Hospital
RECRUITING

Kure, Hiroshima, 737-8505, Japan
Maharaja Agrasen Superspeciality Hospital
RECRUITING

Jaipur, Rajasthan, 302039, India
Methodist Hospital Southlake
RECRUITING

Merrillville, Indiana, 46410, United States
NHO Kinki Chuo Chest Medical Center
NOT_YET_RECRUITING

Sakai, Osaka, 591-8555, Japan
National Hospital Organization Okinawa Hospital
RECRUITING

Ginowan, Okinawa, 901-2214, Japan
National Taiwan University Hospital
NOT_YET_RECRUITING

Taipei, 10002, Taiwan
National Taiwan University Hospital - Hsinchu branch
NOT_YET_RECRUITING

Hsinchu, 302, Taiwan
NewportNativeMD, Inc.
RECRUITING

Newport Beach, California, 92663, United States
Nishifukuoka Hospital
RECRUITING

Fukuoka, Fukuoka, 819-8555, Japan
Ocala Lung and Critical Care Associates
RECRUITING

Ocala, Florida, 34471, United States
Paul A. Shapero, MD, PA
NOT_YET_RECRUITING

Bangor, Maine, 04401, United States
Premier Research Center, LLC
RECRUITING

Hendersonville, Tennessee, 37075, United States
Pulmonary Associates of Mobile, P.C.
RECRUITING

Mobile, Alabama, 36608, United States
Pulmonary Associates, PA
RECRUITING

Phoenix, Arizona, 85027, United States
Reed Medical Research
RECRUITING

Miami, Florida, 33176, United States
Renstar Medical Research
RECRUITING

Ocala, Florida, 34470, United States
Revival Research Institute, LLC
RECRUITING

Dearborn, Michigan, 48126, United States
Revive Research Institute, Inc.
RECRUITING

Southfield, Michigan, 48075, United States
Ruijin Hospital Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
SEC Clinical Research
RECRUITING

Dothan, Alabama, 36305, United States
Salem Chest Specialists
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Sherman Clinical Research
RECRUITING

Sherman, Texas, 75090, United States
Shri Guru Ram Rai Institute of Medical & Health Sciences & Shri Mahant lndiresh Hospital
NOT_YET_RECRUITING

Dehradun, Uttarakhand, 248001, India
Sir Ganga Ram Hospital
NOT_YET_RECRUITING

New Delhi, National Capital Territory of Delhi, 110060, India
Southeastern Research Center
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Southern Clinical Research, LLC
NOT_YET_RECRUITING

Zachary, Louisiana, 70791, United States
Synergy Respiratory Care
RECRUITING

Sherwood Park, Alberta, T8H 0N2, Canada
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Ten20 Clinical Research
RECRUITING

Carrollton, Texas, 75010, United States
The Catholic Univ. of Korea Seoul St. Mary's Hospital
NOT_YET_RECRUITING

Seoul, 06591, South Korea
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
NOT_YET_RECRUITING

Seoul, 03312, South Korea
The First People's Hospital of Xinxiang
NOT_YET_RECRUITING

Xinxiang, Henan, 453000, China
The Third Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510150, China
Tokyo Medical University Hachioji Medical Center
NOT_YET_RECRUITING

Hachiōji, Tokyo, 1930998, Japan
Toledo Institute of Clinical Research Inc.
NOT_YET_RECRUITING

Toledo, Ohio, 43617, United States
University of Alabama at Birmingham Lung Health Center
RECRUITING

Birmingham, Alabama, 35233, United States
Velocity Clinical Research, Gaffney
RECRUITING

Gaffney, South Carolina, 29340, United States
Velocity Clinical Research, Spartanburg
RECRUITING

Spartanburg, South Carolina, 29303, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63108, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Washington University School-Cardiovascular Imaging and Clinical Research Core Laboratory
RECRUITING

St Louis, Missouri, 63110, United States
Yamaguchi University Hospital
NOT_YET_RECRUITING

Ube, Yamaguchi, 755-8505, Japan
Zhongda Hospital Southeast University
RECRUITING

Nanjing, Jiangsu, 210009, China