New shot could reduce COPD Flare-Ups

NCT ID NCT07363694

Recruiting now Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study tests an experimental drug called PF-07275315 in adults with moderate-to-severe COPD who have had at least two flare-ups in the past year. Participants receive either the drug or a placebo as injections over several months. The goal is to see if the drug improves lung function and reduces the number of serious breathing attacks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF-07275315 (an experimental drug given as injections)
What this could lead to: If it works, this could provide a new treatment option to help people with COPD breathe easier and have fewer serious flare-ups.
What could go wrong: This is an early-to-mid stage trial, so the drug may not prove effective or safe. Side effects are possible, and results may not apply to all COPD patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATE TO SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Contacts and locations

Locations

AA Medical Research Center
RECRUITING

Flint, Michigan, 48504, United States
ASHA Clinical Research - Munster, LLC
RECRUITING

Hammond, Indiana, 46324, United States
Advanced Pulmonary Research Institute
RECRUITING

Loxahatchee Groves, Florida, 33470, United States
Alina Clinical Trials, LLC.
RECRUITING

Dallas, Texas, 75209, United States
Aso Iizuka Hospital
RECRUITING

Iizuka-shi, Fukuoka, 820-8505, Japan
Barnes-Jewish Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Barnes-Jewish Hospital Investigational Drug Service
RECRUITING

St Louis, Missouri, 63110, United States
Bhaktivedanta Hospital and Research Institute
RECRUITING

Thane, Maharashtra, 401107, India
Bogan Sleep Consultants, LLC
RECRUITING

Columbia, South Carolina, 29201, United States
C.I.C. Mauricie inc.
NOT_YET_RECRUITING

Trois-Rivières, Quebec, G8T 7A1, Canada
California Medical Research Associates
RECRUITING

Northridge, California, 91324, United States
Centricity Research Rincon Pulmonology
RECRUITING

Rincon, Georgia, 31326, United States
Chandler Clinical Trials
NOT_YET_RECRUITING

Chandler, Arizona, 85224, United States
Chang Gung Medical Foundation-Linkou Branch
RECRUITING

Taoyuan, 333, Taiwan
Chengdu Fifth People's Hospital
RECRUITING

Chengdu, Sichuan, 611130, China
China Medical University Hospital
RECRUITING

Taichung, 40447, Taiwan
China-Japan Friendship Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100029, China
Clinical Research Associates of Central PA, LLC
RECRUITING

DuBois, Pennsylvania, 15801, United States
Clinical Research Specialists LLC
RECRUITING

Kissimmee, Florida, 34746, United States
Clinical Research Trials of Florida, Inc.
RECRUITING

Tampa, Florida, 33607, United States
Clinical Research of Rock Hill
RECRUITING

Rock Hill, South Carolina, 29732, United States
Clinical Site Partners, LLC dba Flourish Research
RECRUITING

Winter Park, Florida, 32789, United States
Clinical Trials Center of Middle Tennessee, LLC
RECRUITING

Franklin, Tennessee, 37067, United States
Coastal Medical Research Institute, LLC
RECRUITING

St. Petersburg, Florida, 33704, United States
Coastal Pulmonary and Critical Care, P.L.C
RECRUITING

St. Petersburg, Florida, 33704, United States
Cpcc-Research Llc
RECRUITING

East Point, Georgia, 30344, United States
Dr. Syed Anees Medicine Professional Corporation
RECRUITING

Windsor, Ontario, N8X 1T3, Canada
Exordia Medical Research Inc.
NOT_YET_RECRUITING

Fall River, Massachusetts, 02723, United States
Far Eastern Memorial Hospital
RECRUITING

New Taipei City, 220, Taiwan
Finlay Medical Research
RECRUITING

Greenacres City, Florida, 33467, United States
Fujieda Municipal General Hospital
RECRUITING

Fujieda, Shizuoka, 426-0077, Japan
Greater Heights & Memorial Pulmonary and Sleep
RECRUITING

Houston, Texas, 77008, United States
HCA Florida Ocala Imaging Center
RECRUITING

Ocala, Florida, 34471, United States
Health Concepts
RECRUITING

Rapid City, South Dakota, 57702, United States
Henderson Clinical Trials
RECRUITING

Henderson, Nevada, 89052, United States
Hindusthan Hospital
RECRUITING

Coimbatore, Tamil Nadu, 641028, India
Horizon Clinical Research Group
RECRUITING

Cypress, Texas, 77429, United States
Houston Pulmonary Sleep and Allergy Associates
RECRUITING

Houston, Texas, 77065, United States
IDIM - Instituto de Investigaciones Metabólicas
NOT_YET_RECRUITING

Ciudad Autonoma de Buenos Aires, Buenos Aires, C1012AAR, Argentina
IMAX Clinical Trials
RECRUITING

La Palma, California, 90623, United States
Inner Mongolia People's Hospital
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 010017, China
Institute of HealthCare Assessment d/b/a Apex Clinical Research
RECRUITING

San Diego, California, 92120, United States
Instituto de Salud Respiratoria - (INSARES)
NOT_YET_RECRUITING

Mendoza, 5500, Argentina
Jawahar Lal Nehru Medical College
NOT_YET_RECRUITING

Ajmer, Rajasthan, 305001, India
Jeonbuk National University Hospital
RECRUITING

Jeonju, Jeonbuk-do, 54907, South Korea
Jiangxi Provincial People's Hospital
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330038, China
KLES Dr. Prabhakar Kore Hospital and Medical Research Centre
RECRUITING

Belagavi, Karnataka, 590010, India
Kamineni Hospitals Private Limited
RECRUITING

Hyderabad, Telangana, 500068, India
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Konkuk University Medical Center
RECRUITING

Seoul, 05030, South Korea
Korea University Anam Hospital
RECRUITING

Seoul, Seoul-teukbyeolsi [seoul], 02841, South Korea
Koujunkai Daido Clinic
RECRUITING

Nagoya, Aichi-ken, 457-8511, Japan
Kure Kyosai Hospital
RECRUITING

Kure, Hiroshima, 737-8505, Japan
Maharaja Agrasen Superspeciality Hospital
RECRUITING

Jaipur, Rajasthan, 302039, India
Methodist Hospital Southlake
RECRUITING

Merrillville, Indiana, 46410, United States
NHO Kinki Chuo Chest Medical Center
RECRUITING

Sakai, Osaka, 591-8555, Japan
National Hospital Organization Okinawa Hospital
RECRUITING

Ginowan, Okinawa, 901-2214, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
National Taiwan University Hospital - Hsinchu branch
RECRUITING

Hsinchu, 302, Taiwan
New York Presbyterian Queens
NOT_YET_RECRUITING

Flushing, New York, 11355, United States
NewportNativeMD, Inc.
RECRUITING

Newport Beach, California, 92663, United States
Nil Ratan Sircar Medical College and Hospital
RECRUITING

Kolkata, West Bengal, 700014, India
Nishifukuoka Hospital
RECRUITING

Fukuoka, Fukuoka, 819-8555, Japan
Oakland Medical Research
RECRUITING

Troy, Michigan, 48085, United States
Ocala Lung and Critical Care Associates
RECRUITING

Ocala, Florida, 34471, United States
Paul A. Shapero, MD, PA
NOT_YET_RECRUITING

Bangor, Maine, 04401, United States
Premier Research Center, LLC
RECRUITING

Hendersonville, Tennessee, 37075, United States
Pulmonary Associates of Mobile, P.C.
RECRUITING

Mobile, Alabama, 36608, United States
Pulmonary Associates, PA
RECRUITING

Phoenix, Arizona, 85027, United States
Reed Medical Research
RECRUITING

Miami, Florida, 33176, United States
Renstar Medical Research
RECRUITING

Ocala, Florida, 34470, United States
Renstar Medical Research
RECRUITING

Ocala, Florida, 34471, United States
Revival Research Institute, LLC
RECRUITING

Dearborn, Michigan, 48126, United States
Revive Research Institute, Inc.
RECRUITING

Southfield, Michigan, 48075, United States
Ruijin Hospital Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, Shanghai Municipality, 200025, China
SEC Clinical Research
RECRUITING

Dothan, Alabama, 36305, United States
Salem Chest Specialists
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Sherman Clinical Research
RECRUITING

Sherman, Texas, 75090, United States
Shri Guru Ram Rai Institute of Medical & Health Sciences & Shri Mahant lndiresh Hospital
RECRUITING

Dehradun, Uttarakhand, 248001, India
Sir Ganga Ram Hospital
RECRUITING

New Delhi, National Capital Territory of Delhi, 110060, India
South Texas Medical Research Institute, Inc., DBA TTS Research
RECRUITING

Boerne, Texas, 78006, United States
Southeastern Research Center
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Southern Clinical Research, LLC
RECRUITING

Zachary, Louisiana, 70791, United States
Synergy Respiratory Care
RECRUITING

Sherwood Park, Alberta, T8H 0N2, Canada
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Taizhou Hospital of Zhejiang Province
NOT_YET_RECRUITING

Linhai, Zhejiang, 317000, China
Ten20 Clinical Research
RECRUITING

Carrollton, Texas, 75010, United States
The Affiliated Hospital of Inner Mongolia Medical University
NOT_YET_RECRUITING

Hohhot, Inner Mongolia, 010050, China
The Catholic Univ. of Korea Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
RECRUITING

Seoul, 03312, South Korea
The First People's Hospital of Xinxiang
RECRUITING

Xinxiang, Henan, 453000, China
The People's Hospital of Chizhou
NOT_YET_RECRUITING

Chizhou, Anhui, 247000, China
The Third Affiliated Hospital of Guangzhou Medical University
RECRUITING

Guangzhou, Guangdong, 510150, China
Tokyo Medical University Hachioji Medical Center
RECRUITING

Hachiōji, Tokyo, 1930998, Japan
Toledo Institute of Clinical Research Inc.
NOT_YET_RECRUITING

Toledo, Ohio, 43617, United States
University of Alabama at Birmingham Lung Health Center
RECRUITING

Birmingham, Alabama, 35233, United States
Velocity Clinical Research, Gaffney
RECRUITING

Gaffney, South Carolina, 29340, United States
Velocity Clinical Research, Spartanburg
RECRUITING

Spartanburg, South Carolina, 29303, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63108, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Washington University School-Cardiovascular Imaging and Clinical Research Core Laboratory
RECRUITING

St Louis, Missouri, 63110, United States
Yamaguchi University Hospital
RECRUITING

Ube, Yamaguchi, 755-8505, Japan
Zhongda Hospital Southeast University
RECRUITING

Nanjing, Jiangsu, 210009, China