Double transplant trial aims to fix lungs and blood in one go
NCT ID NCT03500731
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a new approach for people with severe lung disease (like pulmonary fibrosis or COPD) who also have bone marrow failure. First, participants receive a lung transplant to restore breathing. Then, about 8 weeks later, they get a bone marrow transplant using their own stem cells, along with drugs to prepare the body. The goal is to see if this sequence is safe and can restore both lung and blood function. Only 8 adults aged 18-60 are being enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CD3/CD19 negative hematopoietic stem cells, rituximab, alemtuzumab, fludarabine, thiotepa, G-CSF, hydroxyurea
What this could lead to
If successful, this approach could offer a way to treat both lung failure and bone marrow failure in one combined procedure, potentially improving survival and quality of life.
What could go wrong
This is a very early, small trial (phase 1/2) with only 8 participants. The procedures carry high risks, including infection, organ rejection, and death. It is not yet known if the benefits outweigh these risks.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UPMC Presbyterian
RECRUITINGPittsburgh, Pennsylvania, 15214, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••