New lung valve registry aims to improve breathing in severe emphysema
NCT ID NCT04302272
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This registry study is tracking 150 adults with severe emphysema who receive the Spiration Valve System, a one-way valve placed in the lung via a bronchoscope. The goal is to see if the device safely reduces shortness of breath and lung overinflation over 12 to 36 months. Participants must have low collateral ventilation to be eligible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Spiration Valve System (a one-way endobronchial valve device)
What this could lead to
If successful, this could confirm that the Spiration Valve System is a safe and effective option to ease shortness of breath and lung overinflation in severe emphysema patients.
What could go wrong
This is an observational registry, not a randomized trial, so results may be less definitive. Risks include pneumothorax (collapsed lung) and other serious lung events.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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AnMed Health
RECRUITINGAnderson, South Carolina, 29621, United States
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Baylor Scott & White Research Institute
RECRUITINGDallas, Texas, 75204, United States
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Beth Israel Decaconess
RECRUITINGBoston, Massachusetts, 02215, United States
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Dignity Health St. Joseph's Hospital and Medical Center
RECRUITINGPhoenix, Arizona, 85013, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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El Camino, Taft Center for Clinical Research
RECRUITINGMountain View, California, 94040, United States
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LSU Health Shreveport
RECRUITINGShreveport, Louisiana, 71130, United States
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Memorial Hospital at Gulfport
RECRUITINGGulfport, Mississippi, 39501, United States
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Northwestern University, Division of Pulmonary and Critical Care Medicine
RECRUITINGChicago, Illinois, 60611, United States
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Penn State Milton S. Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033, United States
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
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University of Miami
RECRUITINGCoral Gables, Florida, 33146, United States
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75390, United States
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