New lung valve registry aims to improve breathing in severe emphysema

NCT ID NCT04302272

Recruiting now Symptom relief Sponsor: Olympus Corporation of the Americas Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 04, 2026 · Updated 3 times

Summary

This registry study is tracking 150 adults with severe emphysema who receive the Spiration Valve System, a one-way valve placed in the lung via a bronchoscope. The goal is to see if the device safely reduces shortness of breath and lung overinflation over 12 to 36 months. Participants must have low collateral ventilation to be eligible.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Spiration Valve System (a one-way endobronchial valve device)
What this could lead to: If successful, this could confirm that the Spiration Valve System is a safe and effective option to ease shortness of breath and lung overinflation in severe emphysema patients.
What could go wrong: This is an observational registry, not a randomized trial, so results may be less definitive. Risks include pneumothorax (collapsed lung) and other serious lung events.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EMPHYSEMA

Contacts and locations

Locations

AnMed Health
RECRUITING

Anderson, South Carolina, 29621, United States
Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75204, United States
Beth Israel Decaconess
RECRUITING

Boston, Massachusetts, 02215, United States
Dignity Health St. Joseph's Hospital and Medical Center
RECRUITING

Phoenix, Arizona, 85013, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
El Camino, Taft Center for Clinical Research
RECRUITING

Mountain View, California, 94040, United States
LSU Health Shreveport
RECRUITING

Shreveport, Louisiana, 71130, United States
Memorial Hospital at Gulfport
RECRUITING

Gulfport, Mississippi, 39501, United States
Northwestern University, Division of Pulmonary and Critical Care Medicine
RECRUITING

Chicago, Illinois, 60611, United States
Penn State Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Coral Gables, Florida, 33146, United States
University of Texas Health Science Center at Houston
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States

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