Obstructive lung disease

This trial compares two long-acting bronchodilators (formoterol and revefenacin) against the standard short-acting combination (albuterol and ipratropium) for people hospitalized with a COPD flare-up. The goal is to see whether the longer-acting drugs can relieve shortness of bre…

This trial is testing an investigational drug called brenipatide in adults with moderate-to-severe COPD. Participants will receive either brenipatide or a placebo for about a year, alongside standard care. The goal is to see if brenipatide improves lung function and reduces the n…

This study tests whether adding a type of bodywork called Structural Integration to standard pulmonary rehabilitation can help people with COPD expand their chest more easily. Participants will be randomly assigned to receive either the full 10-Series of Structural Integration pl…

This study tests whether mepolizumab, an injectable medication, can improve lung ventilation and reduce mucus plugs in adults with COPD who have elevated eosinophils. Participants receive mepolizumab every 4 weeks for 48 weeks and undergo MRI and CT scans along with breathing tes…

This trial tests whether active remote management—where a respiratory therapist regularly reviews ventilator data and adjusts settings—can improve quality of life and reduce flare-ups in COPD patients with chronic hypercapnia using home breathing support. Participants are randoml…

This pilot trial tests whether tirzepatide, a once-weekly injection used for diabetes and weight loss, can improve lung function and muscle health in overweight adults with COPD. About 30 participants will receive either tirzepatide or standard care for 12 months, with tests meas…

This trial tests an inhaled investigational drug called ALX1 in adults with bronchiectasis, a chronic lung condition that causes coughing and mucus buildup. Participants receive either ALX1 or a placebo for 14 days. The study aims to find safe and effective doses for future resea…

This trial tests whether a special vibrating vest, worn around the chest, can improve lung function in children aged 6 to 12 with non-cystic fibrosis bronchiectasis — a condition where the airways are permanently widened and clogged with mucus. The vest shakes the chest at high f…

This phase 2 trial is testing whether an experimental drug called PRA-216 can safely reduce airway inflammation in people with moderate to severe COPD who have a specific type of inflammation (type 2). Participants will receive either PRA-216 or a placebo, and researchers will mo…

This trial investigates whether a 7-day course of antibiotics works as well as the standard 14-day course for adults hospitalized with a sudden worsening of COPD. The study involves over 500 participants and measures clinical success at 30 days, including symptom improvement and …

This trial tests a single dose of rademikibart, given intravenously, as an add-on treatment for people hospitalized with an acute asthma or COPD flare-up who also have type 2 inflammation. The study includes 40 adults and measures how well the drug improves lung function and cont…

This study tests a program called Snacktivity, which involves doing very short bursts of moderate exercise—like brisk walking for 2 to 5 minutes, several times a day—to see if it can improve thinking skills and the ability to manage daily health in people aged 60 and older with C…

This trial tests whether a telemonitoring device called HCAlert can reduce hospitalizations and emergency visits for people with chronic obstructive pulmonary disease (COPD). Participants use the device at home to regularly measure their health, allowing doctors to spot worsening…

This study tests an inhaled drug called KIT2014 in 36 adults with moderate to severe COPD. Participants will receive either the drug or a placebo daily for 7 days. The main goal is to check safety and how the body handles the drug, with a first look at whether it might help breat…

This trial investigates whether adding an astaxanthin-based dietary supplement to a standard pulmonary rehabilitation program can improve exercise capacity in people with moderate to very severe COPD. Participants take two capsules of the supplement daily for 8 weeks while comple…

This trial investigates a surgical procedure to divide the fissure between lung lobes in people with COPD and emphysema who did not improve after endobronchial valve treatment. The goal is to see if the surgery is safe and feasible, potentially leading to better lung collapse and…

This registry will follow 350 COPD patients starting dupilumab (Dupixent) to see how well it works and how safe it is in real life. Researchers will track flare-ups, lung function, and quality of life over 24 months, comparing them to similar patients not on the drug. The goal is…

This study looks at whether adding a home telemonitoring system to standard nighttime breathing support (non-invasive ventilation) can help people with severe COPD and high carbon dioxide levels. About 92 participants will be split into two groups: one using standard home ventila…

This study tests whether a 4-week course of the antibiotic TMP-SMX (Bactrim) can reduce the number of serious COPD flare-ups in people whose lungs carry Pneumocystis jirovecii, a common fungus. Researchers will compare the antibiotic to a placebo in 630 adults with advanced COPD …

This study tests whether a dedicated clinic for COPD flare-ups can reduce the number of future attacks and improve quality of life. About 240 people who recently had a severe COPD attack will be split into two groups: one gets follow-up at the special clinic, the other gets stand…

This phase 3 trial tests whether a daily tablet called florensocatib can reduce the number of lung flare-ups in people with bronchiectasis, a chronic lung condition. About 904 participants aged 12 to 85 will be randomly assigned to receive either the drug or a placebo for up to 7…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This phase 3 study tests whether an inhaled medication called HSK39004 can improve lung function in people with moderate to severe chronic obstructive pulmonary disease (COPD). Participants receive either the drug or a placebo twice daily for 24 weeks. The main goal is to measure…

This study tests whether a personalized mobile app that gives temperature-related health warnings and safety tips can reduce acute exacerbations (sudden worsening of symptoms) in people with chronic obstructive pulmonary disease (COPD). About 240 participants will either receive …

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This trial investigates whether the sequence of endurance and strength exercises during pulmonary rehabilitation affects muscle strength in people with moderate to severe COPD. Participants are randomly assigned to do either strength training before endurance work or the reverse.…

This study tests a new inhaled drug called HRS-9821 in people with moderate to severe COPD. About 90 participants will receive either the drug or a placebo for 28 days. The main goal is to see if the drug improves lung function, measured by how much air they can exhale in one sec…

This study tests a new inhaled powder called TQC3927 for people with chronic obstructive pulmonary disease (COPD). The goal is to see if different doses can improve lung function and are safe over a short treatment period. About 90 adults aged 40 to 75 with COPD will take part. T…

This study tests the long-term safety and effectiveness of an experimental inhaler called HSK39004 in 300 adults aged 40 to 80 with moderate-to-severe COPD. Participants will use the inhaler twice daily for 52 weeks. The main goal is to monitor side effects and see how well the t…

This study tests whether taking a low dose of the antibiotic azithromycin every day for a year can reduce the number of serious lung infection flare-ups in adults with non-CF bronchiectasis. About 500 participants will receive either azithromycin or a placebo pill, added to their…

This study tests whether adding dupilumab to standard COPD treatment can prevent another flare-up or hospital stay within 90 days. About 754 adults who were recently hospitalized for a COPD exacerbation will receive either dupilumab or a placebo. The goal is to see if the drug re…

This study tests whether higher doses of the drug Respreeza/Zemaira can slow lung damage better than the standard dose in adults with emphysema caused by Alpha-1 antitrypsin deficiency. About 270 participants will receive weekly IV infusions for 3 years. The goal is to find the o…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study will follow 600 adults in Korea who have been prescribed Breztri for COPD, a long-term lung disease. Researchers want to see how safe the drug is in everyday use and whether it works as expected. Participants will take Breztri as their doctor prescribes, and the study …

This study tests a device that targets nerves in the lungs to help people with moderate to severe COPD breathe easier. About 300 participants will be randomly assigned to receive the real treatment or a sham procedure. Researchers will track symptoms, exercise ability, and flare-…

This study tests whether adding the drug doxofylline to standard inhaler therapy can improve lung function in people with stable COPD. 78 participants will take doxofylline or a placebo for 4 weeks, then switch. The main goal is to see if doxofylline increases the amount of air t…

This study will test whether the drug erdosteine, added to standard COPD treatment, can reduce inflammation and oxidative stress in the body. Thirty adults with moderate-to-severe COPD will take either erdosteine or their usual inhaled therapy for 30 days. Researchers will analyz…

This study tests whether a single dose of the RSV vaccine (Arexvy) can reduce moderate-to-severe COPD flare-ups in people who have frequent attacks. Researchers will enroll 320 high-risk patients aged 50+ and follow them for one year. Half will get the vaccine plus standard care,…

This study tests an experimental drug called XKH001 in 75 people with moderate to severe COPD. The drug is given as an injection to see if it can improve lung function and reduce symptoms over 24 to 48 weeks. Participants are randomly assigned to receive either the drug or a plac…

This study tests whether a pulmonary rehabilitation program can improve exercise tolerance and quality of life in women with COPD caused by long-term exposure to biomass fuel smoke. Sixty women who have never smoked but used biomass fuels for cooking or heating will be randomly a…

This study tests whether the antioxidant alpha-lipoic acid can help people recover from sudden worsening of COPD (called exacerbations). 75 adults will receive either a low dose (600 mg), a high dose (1200 mg), or a placebo pill for 10 days, alongside standard hospital care. Rese…

This study tests whether a pharmacist-led mobile game can improve health in adults aged 50 and older with COPD. 126 participants will either receive usual care or use the game at home for 2 weeks with pharmacist guidance. The goal is to see if the game helps with symptoms, inhale…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests whether adding a thorough heart evaluation to standard lung care helps people with mild-to-moderate COPD who also have heart risks. About 350 adults will be randomly assigned to either the combined heart-lung check or usual respiratory care. The goal is to see if…

This study tests a digital health assistant called 'Alex' to help children and teens aged 10 to 19 with asthma. Over six months, the app tracks lung function, symptoms, and medication use, and later gives personalized advice. The goal is to see if it improves asthma control and m…

This study tests the safety of an inhaled medication called TQC3721 in 800 people with moderate to severe chronic obstructive pulmonary disease (COPD). Participants must have completed a previous related study. The main goal is to track side effects and lab abnormalities, while a…

This study tests whether Guben Kechuan Granules, a traditional Chinese medicine, can improve lung function and quality of life in people with COPD who are recovering from a sudden worsening of symptoms. 126 patients will receive either the granules or a placebo on top of standard…

This study looks at the long-term safety of an experimental inhaler called HSK39004 for people with moderate-to-severe chronic obstructive pulmonary disease (COPD). About 300 adults aged 40 to 80 will use the inhaler twice daily for 52 weeks. Researchers will monitor side effects…

This study tests whether a special scan (VQDI) can help doctors pick the best lung area to place tiny valves for severe emphysema. About 285 participants will be randomly assigned to have valve placement guided by either the new scan or the usual CT scan. The goal is to see if th…

This study tests whether adding a modified Chinese herbal decoction (Ma Xing Shi Gan) to standard care helps people with COPD flare-ups recover faster. Two hundred participants will be randomly assigned to receive either standard care alone or standard care plus the herbal formul…

This study tests whether children aged 6–12 with chronic lung infections (like bronchiectasis) can improve their exercise ability and lung clearance using online physiotherapy sessions. Over 12 weeks, 32 children will either receive remote guided breathing exercises and workouts …

This early-stage trial tests an oral probiotic called R-3750 in 27 people with mild-to-moderate COPD. The main goal is to see if it is safe and tolerable. Researchers will also check if it improves breathing and quality of life using a standard questionnaire. The study is not yet…

This Phase 3 trial tests an experimental injection called JKN2401 in 888 people with moderate-to-severe COPD. The goal is to see if it can safely reduce the number of serious flare-ups compared to a placebo. Participants will receive injections every four weeks and be monitored f…

This Phase 2a trial tests whether Hemay005 can reduce lung inflammation in people with moderate to severe COPD. About 120 adults will take Hemay005, the existing drug roflumilast, or a placebo for 12 weeks. Researchers will measure changes in sputum and blood markers to see if He…

This phase 3 trial tests whether taking the antibiotic moxifloxacin for 7 days every 8 weeks (for a year) can reduce lung infection flare-ups in people with non-cystic fibrosis bronchiectasis. 140 adults who have had at least two flare-ups in the past year will be randomly assign…

This study looks at whether the inhaled drug iloprost can safely lower blood pressure in the lungs and improve exercise ability in adults with severe COPD. Fifteen participants will take iloprost 6 to 9 times daily for 12 weeks, with tests before and after treatment. There is no …

This pilot study will test a digital device that attaches to a standard COPD inhaler. The device coaches patients on proper inhaler technique and shares usage data with their healthcare team. Researchers want to see if this approach is practical and helps reduce hospital visits a…

This study tests whether using a BiPAP breathing machine at home can help people with severe COPD who have high carbon dioxide levels. Forty adults will use the machine nightly for a year while continuing standard medications. Researchers will track blood gas levels, breathing sy…

This study tests a 12-week pulmonary rehabilitation program for people with stable COPD. The program includes hospital sessions (education, exercise, nutrition advice, smoking cessation) and home exercises (walking, strength training). Researchers will measure how far participant…

This Phase 3 trial tests an inhaled drug called TQC3721 in 666 people with moderate-to-severe COPD. The drug works by reducing inflammation and opening airways. Participants will inhale the drug or a placebo daily for up to 24 weeks to see if it improves lung function.

This study tests a 20-week program combining a low-calorie diet with exercise in 70 people who have both obesity and COPD. The goal is to see if weight loss can improve how far they can walk in 6 minutes, as well as their lung function, symptoms, and inflammation. If it works, it…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study is testing whether a simple, 1-minute heart recording (ECG) analyzed by a computer can help detect pulmonary embolism, a serious blood clot in the lungs. Researchers will enroll 500 adults who need to be checked for this condition. The goal is to see if this quick, non…

This study is testing a new, easy way to diagnose asthma and COPD using a handheld device that measures carbon dioxide in a person's breath. Instead of the current uncomfortable and time-consuming lung tests, participants simply breathe normally into the device for 75 seconds. Th…

This study tests whether augmented reality (AR) glasses can guide people through a breathing test called spirometry, which is used to diagnose COPD. The trial involves 710 adults and compares AR-guided tests to those led by a trained technician. If the AR system works well, it co…

This large trial will study whether flu and pneumonia vaccines can reduce serious flare-ups and medical costs in people aged 45-80 with COPD. About 7,000 participants will be split into four groups: flu vaccine, pneumonia vaccine, both, or no vaccine. Researchers will track lung …

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This study tests whether teaching COPD patients structured energy conservation techniques—like planning activities, using proper body mechanics, and breathing exercises—can improve their ability to do daily tasks, reduce fatigue, and boost exercise capacity. Seventy patients with…

This study tests whether an AI-powered program can help older adults with serious illnesses like cancer or heart disease manage emotional distress. Participants receive short videos and daily check-ins from a chatbot that teaches practical coping skills, all from their own phone.…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This trial tests whether two simple breathing exercises—alternate nostril breathing and bellows breath—can help people with COPD clear mucus from their lungs, improve lung function, and feel better day-to-day. About 54 participants will practice one of the techniques for 15–20 mi…

This study compares two airway clearance methods—autogenic drainage (a controlled breathing technique) and a flutter device (a handheld tool that vibrates to loosen mucus)—in people with moderate COPD. Over six weeks, researchers will measure changes in shortness of breath, lung …

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This pilot study tests whether a pre-visit questionnaire helps Black parents of preterm infants with chronic lung disease set and achieve health goals during primary care visits. Thirty parents will complete the questionnaire before a well-child visit and then report back on goal…

This study tests whether a wearable hip exoskeleton can reduce breathlessness and improve walking efficiency in people with moderate to severe COPD. Ten participants will walk on a treadmill for 30 minutes with and without the device, while researchers measure breathing, walking …

This study explores whether a mild electrical stimulation on the face (trigeminal nerve) can reduce the feeling of breathlessness. It first tests the technique in healthy volunteers to understand how it affects breathing control, then checks if it is feasible and helpful for peop…

This study tests a home-based pulmonary rehabilitation program for people with COPD. Participants will follow video-guided exercises, track their daily steps, and receive weekly health coaching. The goal is to improve quality of life, reduce breathlessness, and encourage a more a…

This study tests whether a 12-week remote group rehabilitation program, done via video calls and a smartphone app, can help COPD patients living in remote areas start and stick with rehab. It compares this approach to standard in-person rehab. The goal is to see if the remote opt…

This study tests whether a trained community health worker, who provides remote support, can reduce the burden and improve satisfaction for rural caregivers of older veterans with serious illnesses like dementia or cancer. About 480 care partners will be randomly assigned to rece…

This study tests whether adding a blood flow restriction cuff to aerobic exercise helps people with emphysema or COPD build muscle and improve daily function. Sixty participants will either do standard aerobic exercise or the same exercise with the cuff. The goal is to see if thi…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study tests whether a treadmill workout that combines walking downhill (eccentric) and uphill (concentric) is better than standard uphill walking for people with mild to moderate COPD. Forty participants will do 12 exercise sessions over 4 weeks. Researchers will measure leg…

This study tests whether a supervised exercise and education program (pulmonary rehabilitation) can help people with long-term lung diseases like COPD, asthma, and post-TB lung damage in Nigeria, South Africa, and Cameroon. Researchers will enroll 90 patients to see if the progra…

This study looks at whether a structured program led by a physiotherapist can help people with COPD use their inhalers better. Many patients make mistakes that keep the medicine from reaching the lungs, making symptoms worse. Over 12 months, 116 participants will either get the p…

This study tests whether different breathing patterns (pursed-lip breathing with specific inhale/exhale ratios) can improve breathing in people with stable COPD. About 122 participants aged 40 and older will be assigned to one of three breathing ratios or standard care. Researche…

This study looks at whether a pulmonary rehab program for COPD patients that meets only once a week is as good as one that meets three times a week. About 158 people with COPD will take part, doing supervised exercises plus home workouts for 8 weeks. The goal is to make rehab eas…

This study looks at whether inhaling a bronchodilator (salbutamol) at a different lung volume helps it work better in people with COPD. 30 participants will inhale the medication either from a low lung volume (as usually done) or from a higher, more relaxed volume. The goal is to…

This study compares two breathing devices—the Breather and an incentive spirometer—to see which better reduces shortness of breath, improves lung function, and boosts quality of life in people with mild-to-moderate COPD. Eighty adults aged 45 to 65 will use one of the devices and…

This early-stage study looks at whether metformin, a drug used for diabetes, is safe and tolerable for older adults (65+) with COPD who do not have diabetes. Researchers will also check if metformin changes blood markers linked to aging. The goal is to see if this approach is fea…

This study looks at whether a special training method called Pecha Kucha can help people with COPD who use a breathing machine at home. The training aims to increase patients' confidence in managing their symptoms, reduce how much symptoms bother them, and make daily activities e…

This study looks at whether a special breathing exercise (threshold inspiratory muscle training) can make the diaphragm thicker and move better in people with stable COPD. Fifteen participants aged 40-59 with moderate COPD will do the training. The goal is to see if this exercise…

This study tests whether a 12-week telerehabilitation program—supervised resistance and endurance training done at home—can improve exercise capacity and quality of life in 80 adults with bronchiectasis. Participants are randomly assigned to either the training program or usual c…

This study tests whether special breathing exercises and chest therapy led by nurses can help people hospitalized with a sudden worsening of COPD. About 68 adults will either get these nurse-led treatments plus standard care, or standard care alone. The goal is to see if the extr…

This study tests whether a herbal medicine called Lifei Qingchang Granules can improve breathing and quality of life in people with stable bronchiectasis, a chronic lung condition. About 150 adults aged 18-75 who have had at least one flare-up in the past year will take either th…

This study tests whether it is safe to repeat a procedure called metered cryospray in people with COPD and chronic bronchitis who have already had it once. Only 10 participants will be enrolled. The main goal is to see if the treatment can be fully delivered and to track any seri…

This study looks at whether a traditional Chinese herbal drink (Xuanfei Jiangzhuo Decoction) can help older adults (60+) recover faster from a COPD flare-up caused by the flu. About 300 participants will either take the herbal drink plus standard flu medicine or standard flu medi…

This pilot study tests whether a pharmacist-led medication management program can improve safety and reduce shortness of breath in adults with COPD who also have other health conditions. About 92 participants will receive inhaler training and medication advice. The study focuses …

This study looks at whether special 'active' sports shoes can help people with severe COPD walk farther during a 6-minute walk test. About 75 adults with advanced COPD will try both the special shoes and their usual shoes, and researchers will compare how far they walk and how br…

This pilot study will test the Simeox 200, a device designed to help clear mucus from the lungs, in 35 adults with bronchiectasis who produce a lot of phlegm. Participants will use the device twice daily for two weeks, and researchers will measure how much mucus is cleared, along…

This study looks at whether manual therapy (a type of hands-on treatment) can improve how people with COPD walk, including their step length and balance. Researchers will also check if it helps with breathing, muscle strength, and quality of life. The study plans to enroll 40 adu…

This study tests whether a nurse-guided breathing exercise called Pursed Lip Breathing can help people with COPD feel less anxious and have better vital signs (like heart rate and oxygen levels) right after a bronchoscopy. Sixty-four adults with COPD will be randomly assigned to …

This study tests a digital breathing trainer that helps COPD patients strengthen their breathing muscles through forceful inhales and exhales. Sixty participants with moderate to severe COPD will use the device twice daily for eight weeks, alongside standard rehab. Researchers wi…

This study tests if a gentle, non-invasive brain stimulation method can improve memory and attention in people with COPD who have thinking problems. Twenty-four adults with stable COPD and mild cognitive issues will receive either real or fake stimulation for 20 minutes a day, 5 …

This study looks at whether adding expiratory muscle training (using a handheld device) to standard pulmonary rehabilitation can improve lung function, breathing strength, and exercise capacity in adults with bronchiectasis. Forty participants will be randomly assigned to rehab a…

This study tests whether teaching COPD patients how to use their inhalers correctly, via video calls with a nurse, can improve their sleep quality. Researchers will compare sleep scores between those who get the education and those who don't. Sixty adults who already use inhaled …

This study tests a device called 'Golden Rhino' that helps elderly COPD patients use their inhalers correctly. The device uses a weighted valve and musical cues to guide proper breathing. Researchers will compare standard education alone to education plus device training in 82 pa…

This study will compare two methods of giving N-acetylcysteine—a drug that thins mucus—to 70 adults hospitalized with bronchiectasis. Half will receive the drug through a nebulizer (inhaled), and half through an IV. Researchers will measure how well each method reduces sputum thi…

This study tests a lightweight, battery-powered device called MoblO2 that automatically adjusts oxygen flow to keep blood oxygen at a healthy level during exercise. It is designed for people with COPD or interstitial lung disease who need supplemental oxygen. Over two weeks, 48 p…

This study tests whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions. Participants will try both HFNC and standard oxygen therapy for two weeks each …

This study tests whether placing a whiteboard at the bedside with key care information (nurse/doctor names, treatment times, and discharge plans) can reduce anxiety and depression in COPD patients and improve their satisfaction with nursing care. About 128 hospitalized adults wit…

This study looks at why some adults with chronic obstructive pulmonary disease (COPD) accept or decline a home-based pulmonary telerehabilitation program. By comparing the characteristics of those who agreed to participate with those who did not, researchers hope to identify barr…

This study looks at how nasal high-flow therapy—a device that delivers warm, moist air through small nasal tubes—affects the airways of people with severe chronic obstructive pulmonary disease (COPD). Researchers will measure airway resistance and other lung mechanics using a non…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This study tracks people over 40 hospitalized for a COPD flare-up to see how many have a type called eosinophilic COPD, marked by higher levels of certain white blood cells. Researchers will compare hospital stay length and need for breathing support between those with and withou…

This study is testing whether an integrated precision medicine platform can improve how doctors diagnose and manage chronic inflammatory lung diseases like COPD and idiopathic pulmonary fibrosis. Researchers will collect blood and saliva samples for biomarker analysis, monitor in…

This study looks at how well people hospitalized for a COPD flare-up perceive internal body signals — a skill called interoception — and whether that relates to their breathlessness, depression, and sleep quality. Researchers will assess 50 patients using questionnaires and clini…

This trial evaluates an active case-finding strategy to detect pulmonary tuberculosis (TB) among people with chronic obstructive pulmonary disease (COPD) in primary care clinics in Henan, China. The strategy uses computer-aided diagnosis and a rapid TB test during routine COPD vi…

This study follows 250 adults with severe COPD who use a breathing machine at home. Researchers collect data from sensors and regular check-ups to build a model that can warn of an upcoming flare-up. The goal is to catch problems early and reduce hospital visits.

This study uses ultrasound to examine how the right side of the heart and the lungs' blood vessels work together during severe COPD flare-ups. Researchers will measure changes in heart-lung coupling in 115 patients admitted to intensive care, comparing readings during the acute e…

This study looks at whether standard blood tests can help doctors predict the outcome of a sudden worsening of COPD, known as an acute exacerbation. Researchers will examine red blood cell and platelet measurements from routine blood work in 50 hospitalized adults. The goal is to…

This study looks at whether inhaling nitric oxide can improve how well the lungs exchange oxygen during exercise in people with mild to moderate COPD. Researchers will measure lung blood vessel function and breathing efficiency in 80 participants (40 with COPD and 40 healthy volu…

This study tests a more sensitive ultrasound method called speckle tracking echocardiography (STE) to check heart function in newborns. Researchers will scan healthy babies and those with conditions like lung disease or oxygen deprivation to establish normal values and track chan…

This study tests whether using a blood flow restriction (BFR) device during exercise can increase muscle fatigue in people with COPD, potentially making rehab more effective. Forty participants will do one session of resistance or cycling exercise with and without BFR. The goal i…

This study follows people with chronic lung diseases like bronchiectasis, cystic fibrosis, and COPD to understand how bacteria become resistant to antibiotics. Researchers will collect samples and health data over time to map resistance patterns and genetic causes. The goal is to…

This study looks at how different ventilator pressure settings affect breathing and heart function in people with COPD undergoing lung surgery. Forty-eight patients will each try three short pressure settings in random order. The goal is to find which setting keeps the lungs open…

This study will measure leg and handgrip strength in about 2,800 healthy adults and people with chronic lung diseases across Spain, Portugal, and Italy. Researchers want to create normal muscle strength values for these populations and see if the same standards can apply to peopl…

This study aims to find out how often people with FLNA gene mutations develop emphysema, a type of lung disease. Researchers will use chest CT scans, blood tests, and lung function tests in 70 participants. The goal is to confirm if FLNA changes are a cause of unexplained emphyse…

This study looks at whether a new province-wide electronic health record system (called Connect Care) improves outcomes for adults with chronic diseases like diabetes, heart failure, or kidney disease. Researchers will compare hospital readmission and death rates before and after…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study explores whether a technique called LIBS, which maps chemical elements in lung tissue, can help doctors identify possible environmental or workplace causes of chronic lung diseases. Researchers will analyze stored biopsy samples from 70 adult patients using LIBS and an…

This study tests a new computer system that helps pharmacists provide better care for people with COPD, a serious lung disease. The system guides pharmacists to check symptoms, adjust medications, and create action plans. About 25 pharmacy staff and their COPD patients will use t…

This study will screen 200 adults during a lung health campaign to find undiagnosed breathing problems like COPD. Participants will take a simple breathing test. The goal is to learn how many people have hidden lung issues and how this affects their medical care.

This study will compare two non-invasive breathing support methods—a face mask that pushes air in and a special nasal tube that delivers high-flow oxygen—for adults in the emergency room with dangerously low blood oxygen. About 500 participants will be randomly assigned to one me…

This study compares how COPD patients and healthy individuals experience breathlessness at rest, during exercise, and in virtual reality. Researchers will also test whether a placebo (high-flow nasal cannula) can change how breathlessness feels. The goal is to better understand t…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study will expose 24 healthy adults to different levels of wildfire smoke in a safe, controlled room to see how it affects their lungs and brain. Researchers want to understand why some people may be more vulnerable to long-term lung diseases like asthma, COPD, and lung canc…

This study tests a new training program to help nurses teach patients with COPD how to use their inhalers correctly. About 82 registered nurses in Hong Kong will attend a workshop with hands-on practice and follow-up videos. The goal is to see if this training improves nurses' sk…

This study looks back at the hospital records of 1,000 patients with a sudden worsening of COPD (called an acute exacerbation). The goal is to see how doctors choose and change breathing support—like oxygen masks, high-flow nasal cannulas, or ventilators—during a hospital stay. N…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study will test a text-message program called VC-OPTIONS to help Veterans with COPD learn about and use virtual care services like patient portals and telehealth. About 40 Veterans will receive texts from VA's Annie program to see if this approach is easy to use and helpful.…

This study aims to find out how many hospitalized patients in Iraq are malnourished, a problem that can lead to more complications and longer stays. Researchers will screen 300 adults in two hospitals using standard tools to identify those at risk. The goal is to gather data to i…

This study tests a wearable patch called WearME-Pro that tracks lung function in people with COPD during daily life. Over 10 months, 82 adults will use the patch at home and compare its readings to a standard handheld spirometer. The goal is to see if the patch is accurate, easy …

This study will test whether a pulmonary rehabilitation program that includes inspiratory muscle training (using a device called Powerbreathe) can improve diaphragm function in people with COPD. Researchers will use ultrasound to measure diaphragm movement and thickness before an…

This study will follow 120 adults with COPD who are starting triple inhaler therapy as part of their routine care. Researchers will measure a breath biomarker called FeNO at the start to see if it predicts future flare-ups or lung function decline. The goal is to better understan…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will check how common urinary incontinence is in women with COPD who are doing pulmonary rehabilitation. Researchers will measure leakage with a pad test and ask about quality of life. The goal is to understand the problem better so future treatments can be developed.

This study tests whether a special ultrasound technique called shear wave elastography can measure how hard someone is working to breathe. Currently, doctors must insert a balloon-tube into the esophagus to measure breathing effort, which is uncomfortable. Researchers will compar…

This study will enroll 120 adults with asthma or COPD to see how changes in lung function tests (spirometry and impulse oscillometry) relate to how much their breathing improves after using a bronchodilator. Participants will take a standard reversibility test and report their sy…

This study looks at 150 adults hospitalized for a COPD flare-up to find hidden heart and kidney problems. Researchers will use a special discharge care plan and compare readmission rates to past patients. The goal is to understand how often these hidden issues occur and improve f…

This study will follow 100 adults hospitalized for a sudden worsening of bronchiectasis. Researchers will track how conditions like COPD, diabetes, and heart disease, along with disease severity, affect the need for intensive care, length of hospital stay, and risk of death. The …

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why many also experience anxiety and depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and identify biomarkers. The goal is to find clues …

This study aims to understand how chronic obstructive pulmonary disease (COPD) affects the quality of life of patients in Nepal. Researchers will ask 71 adults with COPD to complete questionnaires about their symptoms and daily activities. No treatments or medications are tested;…

This study will test a non-invasive device called ICON® that measures heart function in COPD patients admitted to the respiratory ICU. Researchers want to see if it is reliable and useful for guiding treatment. The study will enroll 96 adults and track changes in cardiac output d…

This study will analyze lung tissue from 150 people with and without COPD using single-cell sequencing. The goal is to understand the molecular changes that drive the disease. Researchers hope this knowledge will point toward new ways to diagnose or treat COPD in the future.

This study looks at whether giving different oxygen levels during rest breaks between short cycling exercises helps people with COPD feel less breathless and exercise more easily. Fifty adults with moderate COPD will do four short cycling sessions with rest in between. Researcher…

This study looks at how long-term use of a BiPAP machine affects the diaphragm—the main breathing muscle—in people with advanced COPD. Researchers will use ultrasound to measure diaphragm thickness and movement over 6 weeks and 12 months in 30 patients. The goal is to learn wheth…

This study will examine tissue and blood samples from 105 adults having lung surgery to understand why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will compare three groups: those with lung disease and pulmo…

This study looks at whether certain substances in the blood, like surfactant protein-D (SP-D), can help doctors predict how severe a COPD attack will be in hospitalized patients. Researchers will measure these markers in 75 adults admitted for a COPD flare-up and compare them to …