Could a simple nasal device replace ventilators for COPD emergencies?

NCT ID NCT06114667

Recruiting now Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a nasal high-flow device to standard non-invasive ventilation (NIV) for treating people who come to the emergency room with a severe COPD flare-up and high carbon dioxide levels. Participants are randomly assigned to receive one of the two breathing supports for two-hour sessions. Researchers measure whether the nasal device is as good as NIV at bringing blood gas levels back to normal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nasal high flow device
What this could lead to: If successful, this could offer a simpler, more comfortable breathing support option for people with COPD flare-ups in the emergency room.
What could go wrong: This is a single study with 174 participants, and it only looks at early treatment in the emergency department. The nasal high flow may not work as well as standard care for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acidosis disorder Acidosis, Respiratory chronic obstructive pulmonary disease Emergencies respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE HYPERCAPNIC ACIDOSIS RESPIRATORY FAILURE WITH HYPERCAPNIA

Contacts and locations

Locations

Centre Hospitalier Universitaire de Poitiers
NOT_YET_RECRUITING

Poitiers, France
Centre hospitalier universitaire de Nimes
NOT_YET_RECRUITING

Nîmes, France
Montpellier University Hospital
RECRUITING

Montpellier, Montepllier, 34000, France

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