Magic mushroom therapy tested for depression in chronic illness patients
NCT ID NCT06782724
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or two very low doses (1mg) in a supervised setting, plus therapy sessions before and after. The trial tracks mood, anxiety, and quality of life for 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin
- What this could lead to
- If it works, this could point toward a new way to treat depression and anxiety in people with serious lung or neurological diseases.
- What could go wrong
- This is an early Phase 2 trial with only 108 people, so results may not apply to everyone. Psilocybin can cause temporary confusion, fear, or nausea during sessions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bispebjerg Hospital
RECRUITINGCopenhagen, Denmark
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Champalimaud Foundation
RECRUITINGLisbon, Portugal
Contact Email: •••••@•••••
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National Institute of Mental Health
RECRUITINGPrague, Czechia
Contact Email: •••••@•••••
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University Medical Center Groningen
RECRUITINGGroningen, Provincie Groningen, Netherlands
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Contact Email: •••••@•••••
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