Could a simple shot replace IV drips for Alpha-1 patients?
NCT ID NCT07555483
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new way to give Alpha1-Proteinase Inhibitor—a medicine that helps protect the lungs in people with Alpha-1 Antitrypsin Deficiency. Instead of getting it through a vein at a clinic, participants will receive it as a weekly injection under the skin. The trial will compare two different doses of the new shot to the standard IV doses, focusing on how the body processes the drug and whether it is safe. About 40 adults are taking part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Alpha1-Proteinase Inhibitor (human) given under the skin
What this could lead to
If it works, this could offer a more convenient way to take the same medication at home instead of at a clinic.
What could go wrong
This is a small, early-stage study focused on safety and drug levels, not yet on long-term benefits. The new injection method may cause skin reactions or not work as well as the IV version.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beaumont Hospital
NOT_YET_RECRUITINGDublin, D09YD60, Ireland
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Cleveland Clinic
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
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Hospital Clinico San Carlos
NOT_YET_RECRUITINGMadrid, Spain
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Hospital Álvaro Cunqueiro
RECRUITINGVigo, Spain
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Instytut Gruzlicy I Charób Pluc
NOT_YET_RECRUITINGWarsaw, Poland
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Leiden University Medical Center
NOT_YET_RECRUITINGLeiden, Netherlands
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Mayo Clinic
NOT_YET_RECRUITINGScottsdale, Arizona, 85259, United States
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Mayo Clinic
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
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Medical University of South Carolina
NOT_YET_RECRUITINGCharleston, South Carolina, 29425, United States
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Pulmonary Associates
NOT_YET_RECRUITINGPhoenix, Arizona, 85032, United States
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Skane University Hospital
RECRUITINGMalmö, Sweden
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UCLA
NOT_YET_RECRUITINGLos Angeles, California, 90095, United States
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UT Southwestern Medical Center
NOT_YET_RECRUITINGDallas, Texas, 75390, United States
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Unidade Local de Saúde Loures-Odivelas
RECRUITINGLoures, Portugal
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Unidade Local de Saúde do Alto Ave
RECRUITINGGuimarães, Portugal
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University of Alabama at Birmingham
NOT_YET_RECRUITINGBirmingham, Alabama, 35233, United States
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University of Florida
NOT_YET_RECRUITINGGainesville, Florida, 32610, United States
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University of Miami
NOT_YET_RECRUITINGMiami, Florida, 33136, United States
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Vijle Sygeheus
RECRUITINGVejle, Denmark
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