Hidden liver harm: study tracks silent damage in genetic disorder
NCT ID NCT02014415
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows 120 adults with Alpha-1 Antitrypsin Deficiency, a genetic condition that can cause lung and liver problems. Researchers use liver biopsies and genetic samples over 5 years to find out who develops liver scarring or cirrhosis and why. The goal is to identify risk factors that are currently overlooked.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal why some people with Alpha-1 Antitrypsin Deficiency develop serious liver disease while others do not, pointing toward future prevention or treatment strategies.
What could go wrong
This is an observational study, not a treatment trial, so it will not directly help participants. It is small (120 people) and may not uncover clear genetic or environmental factors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston University School of Medicine
Boston, Massachusetts, 02118, United States
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Saint Louis University
St Louis, Missouri, 63104, United States
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University of California
San Diego, California, 92103, United States