COPD, severe early onset

This registry will follow 350 COPD patients starting dupilumab (Dupixent) to see how well it works and how safe it is in real life. Researchers will track flare-ups, lung function, and quality of life over 24 months, comparing them to similar patients not on the drug. The goal is…

This study looks at whether adding a home telemonitoring system to standard nighttime breathing support (non-invasive ventilation) can help people with severe COPD and high carbon dioxide levels. About 92 participants will be split into two groups: one using standard home ventila…

This study tests whether a dedicated clinic for COPD flare-ups can reduce the number of future attacks and improve quality of life. About 240 people who recently had a severe COPD attack will be split into two groups: one gets follow-up at the special clinic, the other gets stand…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This phase 3 study tests whether an inhaled medication called HSK39004 can improve lung function in people with moderate to severe chronic obstructive pulmonary disease (COPD). Participants receive either the drug or a placebo twice daily for 24 weeks. The main goal is to measure…

This study tests whether frequent sauna baths can reduce or eliminate bacteria that cause stubborn lung infections in people with conditions like COPD, asthma, or bronchiectasis. Researchers will track how long participants go without needing antibiotics and whether the bacteria …

This study tests a new inhaled drug called HRS-9821 in people with moderate to severe COPD. About 90 participants will receive either the drug or a placebo for 28 days. The main goal is to see if the drug improves lung function, measured by how much air they can exhale in one sec…

This study tests the long-term safety and effectiveness of an experimental inhaler called HSK39004 in 300 adults aged 40 to 80 with moderate-to-severe COPD. Participants will use the inhaler twice daily for 52 weeks. The main goal is to monitor side effects and see how well the t…

This early-stage study tests an inhaled powder called HRS-9821 in healthy volunteers and people with COPD. The main goal is to check safety and how the body handles the drug. About 48 participants will receive either the drug or a placebo.

This study tests a device that targets nerves in the lungs to help people with moderate to severe COPD breathe easier. About 300 participants will be randomly assigned to receive the real treatment or a sham procedure. Researchers will track symptoms, exercise ability, and flare-…

This study will test whether the drug erdosteine, added to standard COPD treatment, can reduce inflammation and oxidative stress in the body. Thirty adults with moderate-to-severe COPD will take either erdosteine or their usual inhaled therapy for 30 days. Researchers will analyz…

This study tests whether a single dose of the RSV vaccine (Arexvy) can reduce moderate-to-severe COPD flare-ups in people who have frequent attacks. Researchers will enroll 320 high-risk patients aged 50+ and follow them for one year. Half will get the vaccine plus standard care,…

This study tests an experimental drug called XKH001 in 75 people with moderate to severe COPD. The drug is given as an injection to see if it can improve lung function and reduce symptoms over 24 to 48 weeks. Participants are randomly assigned to receive either the drug or a plac…

This study tests whether a pharmacist-led mobile game can improve health in adults aged 50 and older with COPD. 126 participants will either receive usual care or use the game at home for 2 weeks with pharmacist guidance. The goal is to see if the game helps with symptoms, inhale…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This study tests whether adding a thorough heart evaluation to standard lung care helps people with mild-to-moderate COPD who also have heart risks. About 350 adults will be randomly assigned to either the combined heart-lung check or usual respiratory care. The goal is to see if…

This early-stage trial tests an oral probiotic called R-3750 in 27 people with mild-to-moderate COPD. The main goal is to see if it is safe and tolerable. Researchers will also check if it improves breathing and quality of life using a standard questionnaire. The study is not yet…

This Phase 2a trial tests whether Hemay005 can reduce lung inflammation in people with moderate to severe COPD. About 120 adults will take Hemay005, the existing drug roflumilast, or a placebo for 12 weeks. Researchers will measure changes in sputum and blood markers to see if He…

This study tests a new exercise approach for people with COPD, a lung disease that makes breathing hard. Researchers will compare standard pulmonary rehab with a version that uses a blood flow restriction cuff during low-intensity aerobic exercise. The goal is to see if this meth…

This study looks at whether the inhaled drug iloprost can safely lower blood pressure in the lungs and improve exercise ability in adults with severe COPD. Fifteen participants will take iloprost 6 to 9 times daily for 12 weeks, with tests before and after treatment. There is no …

This pilot study will test a digital device that attaches to a standard COPD inhaler. The device coaches patients on proper inhaler technique and shares usage data with their healthcare team. Researchers want to see if this approach is practical and helps reduce hospital visits a…

This study tests whether using a BiPAP breathing machine at home can help people with severe COPD who have high carbon dioxide levels. Forty adults will use the machine nightly for a year while continuing standard medications. Researchers will track blood gas levels, breathing sy…

This study tests a 12-week pulmonary rehabilitation program for people with stable COPD. The program includes hospital sessions (education, exercise, nutrition advice, smoking cessation) and home exercises (walking, strength training). Researchers will measure how far participant…

This study tests a 20-week program combining a low-calorie diet with exercise in 70 people who have both obesity and COPD. The goal is to see if weight loss can improve how far they can walk in 6 minutes, as well as their lung function, symptoms, and inflammation. If it works, it…

This study evaluates a portable device that measures lung function using oscillometry—a technique that sends gentle sound waves into the lungs—to diagnose chronic respiratory diseases like COPD, asthma, and bronchiectasis. Researchers will enroll about 4,000 adults across 50 cent…

This study is testing a new, easy way to diagnose asthma and COPD using a handheld device that measures carbon dioxide in a person's breath. Instead of the current uncomfortable and time-consuming lung tests, participants simply breathe normally into the device for 75 seconds. Th…

This study tests a home-based pulmonary rehabilitation program for people with COPD. Participants will follow video-guided exercises, track their daily steps, and receive weekly health coaching. The goal is to improve quality of life, reduce breathlessness, and encourage a more a…

This study tests whether a 12-week remote group rehabilitation program, done via video calls and a smartphone app, can help COPD patients living in remote areas start and stick with rehab. It compares this approach to standard in-person rehab. The goal is to see if the remote opt…

This study tests whether a treadmill workout that combines walking downhill (eccentric) and uphill (concentric) is better than standard uphill walking for people with mild to moderate COPD. Forty participants will do 12 exercise sessions over 4 weeks. Researchers will measure leg…

This study looks at whether adding a continuous saltwater mist to warm, humidified air can make thick lung mucus easier to clear. 35 adults hospitalized with lung conditions like COPD or cystic fibrosis will receive both treatments on separate days. Researchers will measure mucus…

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This study looks at whether a pulmonary rehab program for COPD patients that meets only once a week is as good as one that meets three times a week. About 158 people with COPD will take part, doing supervised exercises plus home workouts for 8 weeks. The goal is to make rehab eas…

This study looks at whether inhaling a bronchodilator (salbutamol) at a different lung volume helps it work better in people with COPD. 30 participants will inhale the medication either from a low lung volume (as usually done) or from a higher, more relaxed volume. The goal is to…

This study compares two breathing devices—the Breather and an incentive spirometer—to see which better reduces shortness of breath, improves lung function, and boosts quality of life in people with mild-to-moderate COPD. Eighty adults aged 45 to 65 will use one of the devices and…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This study tests whether it is safe to repeat a procedure called metered cryospray in people with COPD and chronic bronchitis who have already had it once. Only 10 participants will be enrolled. The main goal is to see if the treatment can be fully delivered and to track any seri…

This study tests a small, portable device called PEP Buddy that Veterans with COPD wear around their neck to help control breathlessness. Researchers will compare it to a sham device that looks the same but only provides the pressure of normal pursed-lip breathing. The goal is to…

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This study looks at whether manual therapy (a type of hands-on treatment) can improve how people with COPD walk, including their step length and balance. Researchers will also check if it helps with breathing, muscle strength, and quality of life. The study plans to enroll 40 adu…

This study tests whether a nurse-guided breathing exercise called Pursed Lip Breathing can help people with COPD feel less anxious and have better vital signs (like heart rate and oxygen levels) right after a bronchoscopy. Sixty-four adults with COPD will be randomly assigned to …

This study tests a digital breathing trainer that helps COPD patients strengthen their breathing muscles through forceful inhales and exhales. Sixty participants with moderate to severe COPD will use the device twice daily for eight weeks, alongside standard rehab. Researchers wi…

This study tests if a gentle, non-invasive brain stimulation method can improve memory and attention in people with COPD who have thinking problems. Twenty-four adults with stable COPD and mild cognitive issues will receive either real or fake stimulation for 20 minutes a day, 5 …

This pilot study tests a mobile app called Respir'air BPCO designed to help people with COPD stay physically active after completing a pulmonary rehabilitation program. About 50 participants will either use the app plus usual care or just usual care alone. Researchers will check …

This study tests a lightweight, battery-powered device called MoblO2 that automatically adjusts oxygen flow to keep blood oxygen at a healthy level during exercise. It is designed for people with COPD or interstitial lung disease who need supplemental oxygen. Over two weeks, 48 p…

This study tests whether placing a whiteboard at the bedside with key care information (nurse/doctor names, treatment times, and discharge plans) can reduce anxiety and depression in COPD patients and improve their satisfaction with nursing care. About 128 hospitalized adults wit…

This study tests whether using a blood flow restriction (BFR) device during exercise can increase muscle fatigue in people with COPD, potentially making rehab more effective. Forty participants will do one session of resistance or cycling exercise with and without BFR. The goal i…

This study looks at how different ventilator pressure settings affect breathing and heart function in people with COPD undergoing lung surgery. Forty-eight patients will each try three short pressure settings in random order. The goal is to find which setting keeps the lungs open…

This study will follow up to 840 people with heart disease or COPD who join a group rehab program. Researchers want to see how many patients take part, how often they attend, and how their test results and quality of life change. The goal is to find out what helps patients improv…

This study tests a new computer system that helps pharmacists provide better care for people with COPD, a serious lung disease. The system guides pharmacists to check symptoms, adjust medications, and create action plans. About 25 pharmacy staff and their COPD patients will use t…

This study compares how COPD patients and healthy individuals experience breathlessness at rest, during exercise, and in virtual reality. Researchers will also test whether a placebo (high-flow nasal cannula) can change how breathlessness feels. The goal is to better understand t…

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study tests a new training program to help nurses teach patients with COPD how to use their inhalers correctly. About 82 registered nurses in Hong Kong will attend a workshop with hands-on practice and follow-up videos. The goal is to see if this training improves nurses' sk…

This study tests whether giving people with heart or lung conditions real-time air pollution data helps them exercise outdoors more safely. 80 participants will use a smartphone platform that tracks their walking and local air quality. The goal is to see if this approach reduces …

This study will test whether a pulmonary rehabilitation program that includes inspiratory muscle training (using a device called Powerbreathe) can improve diaphragm function in people with COPD. Researchers will use ultrasound to measure diaphragm movement and thickness before an…

This study will test how changes in oxygen levels affect the heart's electrical signals in 70 people, some with oxygen dependence and some healthy. Participants will receive increasing amounts of oxygen at night while their heart activity is monitored. The goal is to better under…

This study looks at how the immune system works in people with lung diseases like asthma, COPD, pneumonia, and tuberculosis. Researchers will take a single blood sample from 100 adults to study immune cell changes during inflammation and infection. Participants won't receive dire…

This study will check how common urinary incontinence is in women with COPD who are doing pulmonary rehabilitation. Researchers will measure leakage with a pad test and ask about quality of life. The goal is to understand the problem better so future treatments can be developed.

This study tests whether a special ultrasound technique called shear wave elastography can measure how hard someone is working to breathe. Currently, doctors must insert a balloon-tube into the esophagus to measure breathing effort, which is uncomfortable. Researchers will compar…

This study will enroll 120 adults with asthma or COPD to see how changes in lung function tests (spirometry and impulse oscillometry) relate to how much their breathing improves after using a bronchodilator. Participants will take a standard reversibility test and report their sy…

This study looks at 150 adults hospitalized for a COPD flare-up to find hidden heart and kidney problems. Researchers will use a special discharge care plan and compare readmission rates to past patients. The goal is to understand how often these hidden issues occur and improve f…

This study aims to understand how chronic obstructive pulmonary disease (COPD) affects the quality of life of patients in Nepal. Researchers will ask 71 adults with COPD to complete questionnaires about their symptoms and daily activities. No treatments or medications are tested;…

This study will analyze lung tissue from 150 people with and without COPD using single-cell sequencing. The goal is to understand the molecular changes that drive the disease. Researchers hope this knowledge will point toward new ways to diagnose or treat COPD in the future.

This study looks at how long-term use of a BiPAP machine affects the diaphragm—the main breathing muscle—in people with advanced COPD. Researchers will use ultrasound to measure diaphragm thickness and movement over 6 weeks and 12 months in 30 patients. The goal is to learn wheth…

This study will examine tissue and blood samples from 105 adults having lung surgery to understand why some people with chronic lung disease develop pulmonary hypertension (high blood pressure in the lungs). Researchers will compare three groups: those with lung disease and pulmo…

This study looks at whether certain substances in the blood, like surfactant protein-D (SP-D), can help doctors predict how severe a COPD attack will be in hospitalized patients. Researchers will measure these markers in 75 adults admitted for a COPD flare-up and compare them to …