COPD, severe early onset

This study tests whether a structured care program (called a transition bundle) helps people with COPD recover better after a serious flare-up. The program includes guided steps and regular check-ins. About 1,368 patients across 36 hospitals will take part. The goal is to see if …

This study compares three different dual bronchodilator inhalers (Anoro, Ultibro, Spiolto) against a single bronchodilator (Spiriva) in 100 people with COPD. The goal is to see which treatment improves exercise endurance the most. Each participant will try all four treatments for…

This study tests whether atorvastatin, a widely used cholesterol medication, can reduce inflammation and prevent flare-ups in smokers with chronic obstructive pulmonary disease (COPD). About 460 participants will receive either atorvastatin or a placebo for several months. The go…

This study tests whether using a handheld breathing device (OPEP) at home, combined with aerobic exercise, can reduce serious flare-ups and hospital visits in people with moderate to severe COPD. About 312 participants aged 40-80 will be split into four groups: standard care, OPE…

This study tests whether regular follow-up calls or visits from a nurse can help smokers aged 35-65 who are screened for COPD to quit smoking. About 233 participants will receive ongoing nursing support. The goal is to see if this simple, low-cost approach reduces the number of c…

This early trial is testing a device called the Implantable Artificial Bronchus (IAB) in 20 adults with COPD or emphysema. The device is placed in the airways using a bronchoscope to relieve lung overinflation and improve airflow. The main goal is to check safety, looking for ser…

This study tests whether a special training program for primary care doctors can help people with COPD take their medications more regularly. The training includes updated COPD guidelines, inhaler technique workshops, and motivational interviewing. Researchers will compare medica…

This Phase 2 trial tests a new biologic drug called JKN24011 in 215 people with moderate to severe COPD. Participants receive either the drug or a placebo as a shot under the skin every four weeks. The main goal is to see if the drug can reduce the number of moderate or severe CO…

This study looks at 150 adults with COPD who have just had a breathing tube removed. It compares two ways to help them breathe: a high-flow nasal cannula (a soft tube that delivers warm, moist oxygen) versus noninvasive ventilation (a mask that pushes air into the lungs). The goa…

This early-stage study is testing an experimental drug called GB-0895 in 156 adults with mild-to-moderate asthma or COPD. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo as an injection under the skin.…

This study tests a new nurse-led counselling program designed to help people with stable COPD manage emotional distress. Fifteen outpatients will receive ten counselling sessions over three months. The main goal is to see if the program is feasible, not to prove it works. Researc…

This small pilot study tests whether an inhaled medication called Treprostinil can reduce breathlessness and improve exercise ability in people with mild COPD. Twenty participants will take either the drug or a placebo and undergo lung function tests, exercise tests, and imaging.…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This early-stage study tests a new drug called GSK3862995B to see if it is safe and tolerable. First, healthy adults receive a single dose, then people with chronic obstructive pulmonary disease (COPD) receive multiple doses. The goal is to check for side effects and how the drug…

This study is testing whether taking probiotic capsules daily for 16 weeks can reduce shortness of breath and improve lung function in people with COPD. Sixty adults with stable COPD will receive either the probiotic or a placebo. Researchers will measure changes in breathing, sy…

This study tests whether using a breathing muscle training device, along with standard physical therapy, helps people recover more quickly after a lung transplant. About 90 adults waiting for a lung transplant will take part. The goal is to see if this training improves breathing…

This study tests a low-cost, equipment-free exercise program for people with COPD who have trouble getting up from the floor. The program uses simple floor-to-stand movements done at home and with supervision for 9 weeks, with a check-up at 18 months. The goal is to see if this p…

This study tests whether an 8-week Clinical Pilates program can improve lung function, chest mobility, motor performance, sleep, and quality of life in 38 people with mild (Gold A) COPD. Participants will attend two 60-minute sessions per week using soft balls and elastic bands. …

This study compares standard pulmonary rehabilitation exercises to rehabilitation through dance for people with chronic obstructive pulmonary disease (COPD). Forty-four participants will be randomly assigned to either standard rehab or dance-based rehab for 8 weeks. The goal is t…

This study follows 200 adults aged 30-55 who smoke or have early COPD to learn how the disease progresses. Researchers will use breathing tests, symptom surveys, and CT scans to find early warning signs. The goal is to better understand risk factors and improve future care for CO…

This study will follow 3,000 people with COPD who have frequent flare-ups to see how the disease changes over time and what treatments they receive. Researchers will collect information from medical records and surveys to understand treatment patterns, quality of life, and caregi…

This study looks at whether having a heart doctor check patients during a COPD flare-up helps find and treat hidden heart problems. 150 hospitalized adults with COPD are randomly assigned to see only a lung doctor or also a heart doctor. Researchers then track changes in heart tr…

This study looks at how ozone, a common air pollutant, affects immune cells in the lungs of people with COPD. Researchers will expose 72 participants (including healthy non-smokers, smokers without COPD, and COPD patients) to ozone in a controlled chamber and track changes in the…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at how changing the pressure inside a breathing machine affects lung function in 20 patients with obstructive airway diseases who are on full ventilator support. Researchers will test different pressure levels to see how they impact gas exchange and how the lungs…

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 participants over several years to track changes in lung function. The goal is to better understand why some patients struggle wi…

This study is testing whether a breathing test called the lung clearance index (LCI) can detect small airways disease in adults with chronic lung conditions like asthma or fibrosis. Researchers will compare results from 300 patients with lung disease to 300 healthy volunteers. Th…

This study looks at whether high-intensity interval training (HIIT) can help regenerate lung tissue in people with COPD who are waiting for lung volume reduction surgery. 24 participants will be randomly assigned to either a HIIT exercise program or no exercise. Researchers will …

This study looks at 1,600 adults in Hong Kong who have been diagnosed with asthma or COPD to find out how many have both conditions (called Asthma-COPD Overlap). Researchers will track their health for 3 years to see how they do and whether their treatment matches guidelines. The…

This study compares 16 people with mild-to-moderate COPD to 16 healthy volunteers matched by age, sex, and height. Researchers measure blood volume in the lungs and the whole body to see if a smaller lung blood volume contributes to exercise problems. No treatment is given—the go…

This study looks at whether a structured exercise and education program (pulmonary rehabilitation) can reduce inflammation and oxidative stress in people with stable COPD. Researchers will measure specific blood markers before and after the program in 27 adults aged 40-80. The go…

This study aims to improve how doctors communicate with patients facing serious illnesses like cancer, heart failure, COPD, or dementia. Researchers will give doctors detailed feedback on their conversations about goals of care. The goal is to help patients receive care that matc…

This study was designed to test whether eccentric cycling (a type of exercise that focuses on lengthening muscles) could improve heart and lung fitness and quality of life in people with chronic obstructive pulmonary disease (COPD). The plan was to compare eccentric cycling to st…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study is refining a questionnaire to help doctors detect small airway dysfunction in people with COPD. Researchers will also compare two breathing tests (spirometry and oscillometry) to see which works better in primary care. About 108 adults with asthma, COPD, or both will …

This study aimed to use a special MRI technique with hyperpolarized xenon gas to see how lung function changes in people with COPD after a procedure called targeted lung denervation. The goal was to better understand how the treatment affects breathing. However, the study was wit…

This study tests a wearable device called the RESP™ Biosensor that listens to lung sounds and chest movements. It is designed to help monitor people with COPD after they leave the hospital. The goal is to see if the device can detect early signs of a COPD flare-up, so patients ca…

This study tests whether personalized emails to GP practices can improve prescribing for COPD, a long-term lung condition. About 270 practices in West Yorkshire, UK, will receive either a generic or a tailored email alongside their regular feedback reports. The goal is to see if …

This study is creating a personalized prediction system for acute exacerbations (sudden worsening) of chronic obstructive pulmonary disease (COPD). Over 3 years, researchers will collect health data from 442 COPD patients and healthy volunteers, including breathing tests, symptom…

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study aims to find COPD earlier in people who are already getting a lung CT scan as part of a lung health check. Researchers will invite 568 current or former smokers to take a simple breathing test a few weeks after their CT scan. The goal is to see if this approach helps d…

This study aims to see if a simple, non-invasive breathing test can accurately measure the acidity (pH) in the airways, which is often abnormal in lung diseases. Researchers will compare results from this breath test with standard methods in 150 healthy volunteers and people with…

This study follows nearly 3,000 people with COPD (a chronic lung disease) over several years to understand how the disease progresses and what factors influence it. Researchers measure lung function, analyze mucus, and track environmental exposures like air pollution. The goal is…

This study watches 200 people with lung, gut, or hormone diseases over time using special brain scans (PET). It aims to see how these diseases change brain activity and whether those changes can predict tumor return, spread, or survival. No new treatment is tested—just observatio…

This study is looking at over 10,000 smokers to find out if certain genes make some people more likely to develop COPD, a serious long-term lung disease. Participants are having their lung function tested and getting chest CT scans. The goal is to understand why some smokers get …