New drug targets lung cancer protein, aims to shrink tumors and extend life

NCT ID NCT07099898

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tests a new medicine called Risvutatug rezetecan (Ris-Rez) that targets a specific protein (B7-H3) on cancer cells to stop their growth. It is for adults with relapsed small cell lung cancer who have already tried one prior treatment. About 420 participants will be randomly assigned to receive either Ris-Rez or the standard drug topotecan, and researchers will compare how well each shrinks tumors and helps people live longer, while also checking side effects.

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Conditions

The condition(s) this trial relates to.

lung neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS, LUNG

Contacts and locations

Locations

GSK Investigational Site
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Mar del Plata, Buenos Aires, 7600, Argentina
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Buenos Aires, C1426ABP, Argentina
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Ciudad Autonoma de Buenos Aire, C1012AAR, Argentina
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Ciudad Autonoma de Buenos Aire, C1426AGE, Argentina
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Rosario, S2000 DEJ, Argentina
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Vicente López, 1602, Argentina
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Blacktown, New South Wales, 2148, Australia
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St Leonards, New South Wales, 2065, Australia
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Nedlands, Western Australia, 6009, Australia
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Barretos, 14784-400, Brazil
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CuritibaPR, 80810-050, Brazil
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Florianópolis, 88020-210, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90610-000, Brazil
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Rio de Janeiro, 22250-905, Brazil
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São Paulo, 04312903, Brazil
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Pleven, 5800, Bulgaria
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Plovdiv, Bulgaria
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Rousse, 7002, Bulgaria
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Sofia, 1606, Bulgaria
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Sofia, 1632, Bulgaria
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 1Z5, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4J 1C5, Canada
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Vaasa, 65130, Finland
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Boulogne-Billancourt, 92100, France
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Grenoble, 38043, France
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Saint-Herblain, 44805, France
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Karlsruhe, Baden-Wurttemberg, 76137, Germany
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Augsburg, 86156, Germany
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Chemnitz, 09113, Germany
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Esslingen am Neckar, 73730, Germany
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Löwenstein, 74245, Germany
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Lübeck, 23562, Germany
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München, 81377, Germany
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Nuremberg, 90340, Germany
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Stuttgart, 70376, Germany
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Athens, 115 22, Greece
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Athens, 11526, Greece
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Athens, 12462, Greece
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Heraklion, 71110, Greece
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Pylaia Thessaloniki, 570 01, Greece
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Pylaia Thessaloniki, 57001, Greece
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Budapest, H-1121, Hungary
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Farkasgyepű, 8552, Hungary
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Gyöngyös, 3200, Hungary
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Kecskemét, 6000, Hungary
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Székesfehérvár, 8000, Hungary
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Törökbálint, 2045, Hungary
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Dublin, D09 V2N0, Ireland
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Jerusalem, 9112001, Israel
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Tel Aviv, 6423906, Israel
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Bergamo, Italy
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Milan, 20141, Italy
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Orbassano, 10043, Italy
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Pisa, 57124, Italy
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Siena, 53100, Italy
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Verona, 37134, Italy
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Fukuoka, 812-8582, Japan
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Hokkaido, 060-8648, Japan
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Ishikawa, 920-8530, Japan
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Kagoshima, 890-8520, Japan
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Kanagawa, 241-8515, Japan
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Kanagawa, 252-0375, Japan
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Kochi, 783-8505, Japan
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Kyoto, 612-8555, Japan
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Mie, 515-8544, Japan
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Miyagi, 980-8574, Japan
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Osaka, 541-8567, Japan
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Osaka, 573-1191, Japan
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Osaka, 594-0073, Japan
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Tokyo, 104-0045, Japan
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Tokyo, 113-8603, Japan
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Tokyo, 113-8677, Japan
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Toyama, 930-8550, Japan
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Guadajalara, 44280, Mexico
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Mexico City, 06700, Mexico
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Mexico City, 06760, Mexico
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San Pedro Garza García, 66260, Mexico
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Kielce, 25-640, Poland
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Lodz, 93-338, Poland
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Otwock, 05-400, Poland
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Poznan, 60-569, Poland
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Siedlce, 08-110, Poland
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Almada, 2805-267, Portugal
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Guimarães, 4835-044, Portugal
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Craiova Dolj, Dolj, 200535, Romania
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Cluj-Napoca, 400015, Romania
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Craiova, 200542, Romania
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Floreşti, 407280, Romania
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Iași, 700451, Romania
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Timișoara, 300329, Romania
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Changwon, 51472, South Korea
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Cheongju Chungcheongbuk-do, 28644, South Korea
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Daegu, 41404, South Korea
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Gyeonggi-do, 10408, South Korea
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Seongnam-si Gyeonggi-do, 13620, South Korea
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Seoul, 03722, South Korea
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Suwon Gyeonggi-do, 442723, South Korea
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Ulsan, 44033, South Korea
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Barcelona, 08035, Spain
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Barcelona, 8017, Spain
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Barcelona, 8036, Spain
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L'Hospitalet de Llobrega, 08908, Spain
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Las Palmas de Gran Canar, 35016, Spain
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Madrid, 28007, Spain
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Madrid, 28034, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Santander, 39011, Spain
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Stockholm, 171 64, Sweden
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Basel, 4031, Switzerland
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Lausanne, 1011, Switzerland
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Adana, Adana, 01140, Turkey (Türkiye)
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Samsun, Atakum, 55200, Turkey (Türkiye)
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Diyarbakır, 21280, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
GSK Investigational Site
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Izmir, 35110, Turkey (Türkiye)
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Izmir, 35340, Turkey (Türkiye)
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London, W1G 6AD, United Kingdom
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Portsmouth, PO6 3LY, United Kingdom
GSK Investigational Site
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Truro, TR1 3LJ, United Kingdom

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