Could a single drug replace chemo for some colon cancers?

NCT ID NCT05855200

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests the immunotherapy drug dostarlimab against standard chemotherapy in 892 people with a specific type of colon cancer (dMMR/MSI-H) that has not spread. The goal is to see if dostarlimab alone can prevent cancer from coming back or causing death. Participants will receive either dostarlimab or standard chemo before and after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dostarlimab
What this could lead to: If successful, this could offer a chemotherapy-free option for certain colon cancers, potentially reducing side effects and improving outcomes.
What could go wrong: This is an early-phase trial, and results may not confirm benefit. Risks include immune-related side effects from dostarlimab, and it may not work for all participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon adenocarcinoma colonic neoplasm colorectal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLONIC NEOPLASMS NEOPLASMS, COLON

Contacts and locations

Locations

GSK Investigational Site
RECRUITING

Tucson, Arizona, 85715, United States
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Los Angeles, California, 90027, United States
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New Haven, Connecticut, 06520, United States
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Washington D.C., District of Columbia, 20010, United States
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Deerfield Beach, Florida, 33064, United States
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Fort Lauderdale, Florida, 33316, United States
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Marietta, Georgia, 30060, United States
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Chicago, Illinois, 60611, United States
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Chicago, Illinois, 60612, United States
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WITHDRAWN

Chicago, Illinois, 60637, United States
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Naperville, Illinois, 60126, United States
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Naperville, Illinois, 60540, United States
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Westwood, Kansas, 66205, United States
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Lexington, Kentucky, 40503, United States
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Louisville, Kentucky, 40206, United States
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Baton Rouge, Louisiana, 70809, United States
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Bethesda, Maryland, 20817, United States
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Ann Arbor, Michigan, 48109, United States
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Detroit, Michigan, 48202, United States
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Minneapolis, Minnesota, 55455, United States
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Joplin, Missouri, 64804, United States
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St Louis, Missouri, 63128, United States
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St Louis, Missouri, 63141, United States
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Grand Island, Nebraska, 68803, United States
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Omaha, Nebraska, 68130, United States
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Omaha, Nebraska, 68198, United States
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Lebanon, New Hampshire, 03756, United States
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New York, New York, 10028, United States
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New York, New York, 10469, United States
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New York, New York, 11042, United States
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New York, New York, 11967, United States
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The Bronx, New York, 10461, United States
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Durham, North Carolina, 27710, United States
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Akron, Ohio, 44304, United States
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Cincinnati, Ohio, 45220, United States
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Cleveland, Ohio, 44111, United States
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Cleveland, Ohio, 44142, United States
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Cleveland, Ohio, 44196, United States
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Oklahoma City, Oklahoma, 73104, United States
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Oklahoma City, Oklahoma, 73120, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Sioux Falls, South Dakota, 57078, United States
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Sioux Falls, South Dakota, 57105, United States
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Sioux Falls, South Dakota, 57401, United States
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Sioux Falls, South Dakota, 57501, United States
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Dallas, Texas, 75235, United States
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Dallas, Texas, 75390, United States
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Richmond, Virginia, 23229, United States
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Appleton, Wisconsin, 54911, United States
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Buenos Aires, 1093, Argentina
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Buenos Aires, C1180AAX, Argentina
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Buenos Aires, C1181ACH, Argentina
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Capital Federal, C1426ANZ, Argentina
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Ciudad Autonoma de Buenos Aire, C1431FWO, Argentina
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Córdoba, 5000, Argentina
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Mar del Plata, 7600, Argentina
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Rosario, S2002, Argentina
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San Miguel de Tucumán, T4000IHE, Argentina
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Santa Fe, S3000FUJ, Argentina
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Newcastle, New South Wales, 2298, Australia
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St Leonards, New South Wales, 2065, Australia
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Woolangabba, Queensland, 4102, Australia
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Heidelberg, Victoria, 3084, Australia
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Melbourne, Victoria, 3004, Australia
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Aalst, 9300, Belgium
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Brussels, 1070, Belgium
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Brussels, 1200, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Liège, 4000, Belgium
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Roeselare, 8800, Belgium
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Barretos, 14784-400, Brazil
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Belém, 66.073-005, Brazil
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Campo Grande, 79002-061, Brazil
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Lages, 88501-001, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90610-000, Brazil
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Salvador, 40414-120, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01509-010, Brazil
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São Paulo, 04312903, Brazil
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Teresina, 64049-200, Brazil
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Vitória, 29043-260, Brazil
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Edmonton, Alberta, T6G 1Z2, Canada
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Halifax, Nova Scotia, B3H 1V7, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Beijing, 100036, China
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Beijing, 100083, China
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Beijing, 100730, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400042, China
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Chongqing, 400042, China
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Guangzhou, 510060, China
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Guangzhou, 510655, China
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Hangzhou, 310016, China
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Hangzhou, 310022, China
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Hangzhou, 311100, China
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Hangzhou, China
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Harbin, 150000, China
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Jinan, 250117, China
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Kunming, 650106, China
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Meizhou, 514700, China
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Nanchang, 330006, China
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Nanchang, 330029, China
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Shanghai, 200032, China
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Shanghai, 200032, China
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Shenzhen, 518036, China
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Taiyuan, 030013, China
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Tianjin, 300000, China
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Wuhan, 430030, China
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Xiamen, 361004, China
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Yangzhou, 225001, China
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Zhengzhou, 450052, China
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Hradec Králové, 500 05, Czechia
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Nový Jičín, 741 01, Czechia
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Prague, 150 06, Czechia
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Tallinn, 11312, Estonia
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Tallinn, 13419, Estonia
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Tartu, 50501, Estonia
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Helsinki, 00029, Finland
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Tampere, 33520, Finland
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Turku, 20521, Finland
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Lyon, 69008, France
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Marseille, 13385, France
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Nantes, 44093, France
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Paris, 75015, France
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Pessac, 33604, France
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Rennes, 35042, France
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COMPLETED

Rouen, 76000, France
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Saint-Priest-en-Jarez, 42270, France
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Suresnes, 92150, France
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Toulouse, 31059, France
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Villejuif, 94805, France
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Berlin, 13353, Germany
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Düsseldorf, 40225, Germany
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Frankfurt, 60488, Germany
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WITHDRAWN

Halle, 06120, Germany
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Lübeck, 23562, Germany
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Mannheim, 68167, Germany
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München, 81377, Germany
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München, 81737, Germany
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COMPLETED

Athens, 11528, Greece
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Thessaloniki, 54639, Greece
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COMPLETED

Thessaloniki, 570 10, Greece
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Bengaluru, Karnataka, 560076, India
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Ludhiana, Punjab, 141123, India
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Belagavi, 590010, India
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Hyderabad, 500034, India
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Nashik, 422002, India
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Pune, 411040, India
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Cagliari, 09042, Italy
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Genova, 16132, Italy
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Milan, 20162, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Pisa, 56126, Italy
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Reggio Emilia, 40123, Italy
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Roma, 00152, Italy
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Roma, 00168, Italy
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Rozzano MI, 20089, Italy
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Aichi, 464-8681, Japan
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Chiba, 277-8577, Japan
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Fukuoka, 812-8582, Japan
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Hokkaido, 060-8648, Japan
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WITHDRAWN

Hyōgo, 650-0047, Japan
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Ibaraki, 309-1793, Japan
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Kanagawa, 216-8511, Japan
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Kanagawa, 232-0024, Japan
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Kyoto, 606-8507, Japan
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Okayama, 710-8602, Japan
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Osaka, 540-0006, Japan
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Osaka, 541-8567, Japan
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Osaka, 558-8558, Japan
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Osaka, 565-0871, Japan
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Osaka, 573-1191, Japan
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Shizuoka, 411-8777, Japan
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Tokyo, 104-0045, Japan
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Tokyo, 135-8550, Japan
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DF, 14000, Mexico
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Guadalajara, 44280, Mexico
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COMPLETED

Guadalajara, 44650, Mexico
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Mexico City, 03100, Mexico
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Oaxaca City, 68020, Mexico
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COMPLETED

San Pedro Garza García, 66220, Mexico
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Tijuana, 22010, Mexico
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Breda, 4818 CK, Netherlands
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Maastricht, 6229 HX, Netherlands
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Nijmegen, 6525 GA, Netherlands
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Utrecht, 3584 CX, Netherlands
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Bergen, 5021, Norway
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Kristiansand, 4604, Norway
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Lrenskog, 1474, Norway
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Oslo, 0407, Norway
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Stavanger, 4011, Norway
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WITHDRAWN

Tromsø, 9019, Norway
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Punta Pacifica Panama City Panama, Panama
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Bydgoszcz, 85-048, Poland
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Warsaw, 02-034, Poland
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Almada, 2805-267, Portugal
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Coimbra, 3000-075, Portugal
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Lisbon, 1649-035, Portugal
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Daegu, 41404, South Korea
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Gyeonggi-do, 463712, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 138-736, South Korea
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Badajoz, 06080, Spain
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BaracaldoVizcaya, 48903, Spain
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Barcelona, 08026, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Córdoba, 14004, Spain
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Donostia / San Sebastian, 20080, Spain
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Elche Alicante, 03203, Spain
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Granada, 18014, Spain
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Jaén, 23007, Spain
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L'Hospitalet de Llobrega, 08908, Spain
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Las Palmas de Gran Canar, 35016, Spain
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Madrid, 28006, Spain
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Madrid, 28009, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Madrid, 28050, Spain
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Madrid, 28222, Spain
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Málaga, 29010, Spain
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Oviedo, 33011, Spain
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Pamplona, 31008, Spain
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Santander, 39011, Spain
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Seville, 41013, Spain
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Valencia, 46009, Spain
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Valencia, 46010, Spain
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Valencia, 46014, Spain
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Zaragoza, 50009, Spain
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Eskilstuna, 63349, Sweden
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Gothenburg, SE-413 45, Sweden
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Linköping, SE-581 85, Sweden
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Malmö, 20502, Sweden
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Stockholm, 11219, Sweden
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Stockholm, 11883, Sweden
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Uppsala, SE-751 85, Sweden
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Kaohsiung City, 833, Taiwan
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Tainan, 704, Taiwan
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Taipei, 100, Taiwan
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Taoyuan, 333, Taiwan
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Ankara, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Chelmsford, CM1 7ET, United Kingdom
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Cheltenham, GL53 7AN, United Kingdom
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Edinburgh, EH4 2XU, United Kingdom
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Hull, HU16 5JQ, United Kingdom
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Leeds West Yorkshire, LS9 7TF, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SW3 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Sutton, SM2 5PT, United Kingdom

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