New study tests belimumab to tame early lupus

NCT ID NCT06411249

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing the drug belimumab (Benlysta) in 350 adults who were diagnosed with systemic lupus erythematosus (SLE) within the last two years and still have active disease despite standard treatment. The goal is to see if adding belimumab helps more people reach a state of low disease activity and reduce their need for steroids over three years. Participants will receive weekly injections of belimumab at home.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belimumab (Benlysta)
What this could lead to: If successful, this study could show that early use of belimumab helps people with lupus achieve a low disease activity state, potentially reducing flares and reliance on steroids.
What could go wrong: This is an open-label, single-arm study with no placebo group, so results may be less definitive. Belimumab can increase the risk of infections and allergic reactions.

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Conditions

The condition(s) this trial relates to.

autoimmune disease systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC LUPUS ERYTHEMATOSUS

Contacts and locations

Locations

GSK Investigational Site
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Anniston, Alabama, 36207, United States
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Flagstaff, Arizona, 86001, United States
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Mesa, Arizona, 85210, United States
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Tucson, Arizona, 85748, United States
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Covina, California, 91722, United States
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Fontana, California, 92335, United States
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Fullerton, California, 92835, United States
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Long Beach, California, 90720, United States
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Los Angeles, California, 90211, United States
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Mission Hills, California, 91345, United States
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San Diego, California, 92128, United States
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Temecula, California, 92592, United States
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Tujunga, California, 91042, United States
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Van Nuys, California, 92307-2333, United States
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Van Nuys, California, 92586, United States
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Whittier, California, 90602, United States
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Aventura, Florida, 33180, United States
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Clearwater, Florida, 33765, United States
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Miami, Florida, 33126, United States
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Tamarac, Florida, 33321, United States
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Tampa, Florida, 33606, United States
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Atlanta, Georgia, 30152, United States
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Sugar Hill, Georgia, 30518, United States
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Morton Grove, Illinois, 60521, United States
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Rockford, Illinois, 60123, United States
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Baton Rouge, Louisiana, 70836, United States
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New Orleans, Louisiana, 70112, United States
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Shreveport, Louisiana, 71115, United States
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Detroit, Michigan, 48202, United States
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Lansing, Michigan, 48910, United States
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Sparta, New Jersey, 07871, United States
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Brooklyn, New York, 11201, United States
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Charlotte, North Carolina, 28202, United States
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Winston-Salem, North Carolina, 27157, United States
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Duncansville, Pennsylvania, 16635, United States
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Philadelphia, Pennsylvania, 19140, United States
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Austin, Texas, 78745, United States
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Baytown, Texas, 77521, United States
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Colleyville, Texas, 76034, United States
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Fort Worth, Texas, 76109, United States
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Houston, Texas, 77089, United States
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Katy, Texas, 77494, United States
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Plano, Texas, 75024, United States
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Waco, Texas, 76710, United States
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Danville, Virginia, 24541, United States
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Glendale, Wisconsin, 53217, United States
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Berazategui, 1884, Argentina
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Buenos Aires, C1121ABE, Argentina
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Buenos Aires, C1406AGA, Argentina
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Ciudad Autonoma Buenos Aires, C1015ABO, Argentina
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Ciudad Autonoma de Buenos Aire, 1425, Argentina
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La Plata, B1900AX, Argentina
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Mar del Plata, 7600, Argentina
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Quilmes, B1878GEG, Argentina
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San Miguel de Tucumán, CP 4000, Argentina
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Santa Fe, S2000DSV, Argentina
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Belo Horizonte, 30150-221., Brazil
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Cuiabá, 78020-840, Brazil
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Juiz de Fora, 36010-570, Brazil
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Passo Fundo, 99010-080, Brazil
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Porto Alegre, 90035-001, Brazil
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Porto Alegre, 90430-001, Brazil
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Porto Alegre, 90610-000, Brazil
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Salvador, 41820-020, Brazil
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São José do Rio Preto, 15090-000, Brazil
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São Paulo, 01323-001, Brazil
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São Paulo, 05403-000, Brazil
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Angers, 49933, France
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Lille, 59800, France
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Pessac, 33604, France
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Rennes, 35200, France
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Saint-Priest-en-Jarez, 42270, France
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Toulouse, 31400, France
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Herne, 44649, Germany
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Lübeck, 23538, Germany
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Mainz, 55131, Germany
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Mainz, 55131, Germany
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Meerbusch, 40668, Germany
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Athens, 11 527, Greece
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Athens, 11527, Greece
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Athens, 12462, Greece
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Heraklion, 71500, Greece
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Thessaloniki, 54642, Greece
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Brescia, 25123, Italy
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Ferrara, 44124, Italy
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Milan, 20132, Italy
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Pisa, 56100, Italy
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Reggio Emilia, 42123, Italy
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Rome, 00168, Italy
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Rozzano, 20089, Italy
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Fukuoka, 807-8556, Japan
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Kanagawa, 252-0375, Japan
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Miyagi, 980-8574, Japan
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Osaka, 590-0197, Japan
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Tokyo, 104-8560, Japan
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Cuauhtémoc, Mexico City, 06090, Mexico
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DF, 14000, Mexico
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Guadalajara Jalisco, 44950, Mexico
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León, 37000, Mexico
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Mexico City, 06700, Mexico
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Mexico City, 06726, Mexico
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Mérida, 97000, Mexico
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Monterrey Nuevo LeOn, 64000, Mexico
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San Luis Potosí City, 78200, Mexico
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Torreón, 27000, Mexico
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Almada, 2805-267, Portugal
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Barcelona, 08003, Spain
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Castellon, 12004, Spain
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Córdoba, 14004, Spain
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Murcia, 30120, Spain
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Seville, 41014, Spain
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Valladolid, 47012, Spain
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VigoPontevedra, 36213, Spain
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Villajoyosa, 3570, Spain

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