Glaxosmithkline

This study is testing whether giving a smaller amount of the RTS,S/AS01E malaria vaccine or using a different vaccination schedule is safe and still triggers a strong immune response. It involves 238 healthy children aged 5 months to 5 years living in an area where malaria is com…

This study looks at how well an RSV vaccine works and how safe it is in adults aged 18 and older who have had a lung or kidney transplant. Researchers will check if the immune response from a previous dose lasts and what happens when participants get another dose. The goal is to …

This study tests a new vaccine designed to prevent urinary tract infections (UTIs) caused by E. coli bacteria. It involves 448 adults aged 18-64, with a focus on safety and immune response in all participants, and early effectiveness in women. The vaccine is given as a shot and c…

This study tests a new chickenpox vaccine in 600 healthy children aged 12-15 months. The goal is to see if the new vaccine works as well as the approved Varivax vaccine when given as a second dose. Children will receive two doses three months apart, and researchers will measure i…

This study tests a new chickenpox vaccine given as a muscle injection in healthy children aged 12 to 15 months. It compares the immune response and safety of this new shot to the standard chickenpox vaccine given under the skin. The study also looks at giving the new vaccine alon…

This study tests an experimental RSV vaccine in Chinese adults aged 18 to 59 who have a higher risk of getting sick from RSV. The goal is to see if the vaccine produces a strong immune response in this group, similar to what was seen in older adults. About 750 participants will r…

This study is testing a shingles vaccine in children aged 1 to 17 who have had a kidney transplant and have a weakened immune system. The goal is to see if the vaccine is safe and helps their bodies fight the virus that causes shingles. About 184 children will take part, receivin…

This study tests a new vaccine designed to protect infants against two serious bacterial infections: invasive nontyphoidal salmonella (iNTS) and typhoid fever. About 537 healthy infants in Africa will receive the vaccine at either 6 weeks or 6 months old. Researchers will monitor…

This early-stage study tests a new mRNA vaccine that aims to protect against both seasonal flu and COVID-19 with a single shot. About 225 healthy adults aged 65 to 85 will receive either the combo vaccine, a standard flu vaccine, or a COVID-19 vaccine. Researchers will monitor si…

This study tests whether the drug belimumab can improve lung function and reduce skin thickening in adults with systemic sclerosis (scleroderma) that has caused lung scarring. About 300 participants will receive either belimumab or a placebo alongside their usual treatments. The …

This study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. It is given together with standard treatments to people with advanced solid tumors (colorectal or prostate cancer). The main goals are to…

This study tests whether adding the drug dostarlimab to standard chemotherapy (CAPEOX) before surgery works better than chemotherapy alone for a common type of colon cancer. About 120 people with stage III or T4N0 colon cancer that has normal DNA repair will take part. The goal i…

This study tests whether a new drug, IDRX-42, works better than the current drug sunitinib for adults with advanced gastrointestinal stromal tumors (GIST) that have spread or can't be removed by surgery and have already been treated with imatinib. About 450 participants will be r…

This study tests whether the immunotherapy drug dostarlimab, given before and after surgery, works better than standard treatments for people with a specific type of colon cancer (dMMR/MSI-H) that has not spread. About 892 participants will be randomly assigned to receive either …

This study tests whether a new drug combination (belantamab mafodotin plus lenalidomide and dexamethasone) works better than the current standard treatment (daratumumab plus lenalidomide and dexamethasone) for people newly diagnosed with multiple myeloma who cannot have a stem ce…

This study tests a new medicine called efimosfermin alfa in people with MASH, a liver disease linked to metabolic issues. The goal is to see if the drug is safe and tolerable for patients with moderate liver scarring (stage F2 or F3). About 1,250 adults will receive either the dr…

This study tests a new experimental drug (GSK5733584) combined with other cancer medicines for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if the combination is safe, tolerable, and effective. About 392 adults with gyn…

This early-stage study tests a new drug called GSK5926371 in people with lupus and similar autoimmune diseases. The drug is designed to target and calm overactive immune cells that cause inflammation and damage. The main goal is to check safety and find the right dose in about 54…

This study offers ongoing access to the drug niraparib for people with ovarian or breast cancer who have already completed a previous niraparib trial and are still benefiting from the treatment. About 30 participants will continue taking niraparib to monitor long-term safety and …

This study tests an injectable drug called depemokimab in 150 adults with severe asthma caused by a type of inflammation linked to high levels of certain white blood cells (eosinophils). The goal is to see if the drug can reduce mucus plugs and airway thickening in the lungs over…

This early-stage study tests a new experimental drug (GSK4527363) for safety and how the body processes it. It includes healthy volunteers and people with active lupus or lung scarring linked to connective tissue disease. The goal is to find a safe dose and watch for side effects…

This study tests a new medicine called depemokimab for people with moderate to severe COPD who have a specific type of inflammation. The goal is to see if adding this drug to standard treatment can reduce the number of serious flare-ups. About 1,200 participants will receive eith…

This study tests an experimental oral drug (GSK5460025) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H), which often make them harder to treat. The drug is given alone or with other cancer medicines to see if it can shrink tumors and how s…

This study tests a new medicine called efimosfermin alfa in 1200 adults with MASH (a type of fatty liver disease) and moderate-to-severe liver scarring. The goal is to see if the drug can improve scarring and reduce liver inflammation without making the disease worse. Participant…

This study tests an experimental medicine called depemokimab in 960 adults aged 40-80 with moderate to severe COPD and high levels of a certain white blood cell (eosinophils). The goal is to see if adding this drug to standard treatment can reduce the number of moderate or severe…

This study tests an experimental drug called depemokimab in adults aged 40-80 with moderate to severe COPD and type 2 inflammation. The goal is to see if adding this medicine to standard care can reduce the number of moderate or severe flare-ups (exacerbations) that require stero…

This study looks at the long-term safety and effectiveness of belimumab in adults with lung scarring (interstitial lung disease) caused by scleroderma or other connective tissue diseases. About 514 people who finished a previous belimumab study will continue treatment for up to 3…

This study tests a drug called dostarlimab combined with chemotherapy (carboplatin and paclitaxel) in 30 Chinese women with advanced or recurrent endometrial cancer that has specific genetic markers (dMMR/MSI-H). The goal is to see if the treatment shrinks tumors and keeps them f…

This early-stage study tests a new drug, GSK5764227, alone or with other cancer medicines, in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug can shrink tumors. About 59…

This study looks at how well the drug belimumab works in everyday medical practice for adults with active lupus nephritis, a kidney disease caused by lupus. Researchers will follow about 300 people for up to 5 years to see if their kidney function stays stable and if they avoid n…

This study tests whether giving the drug belantamab mafodotin less often, combined with other standard cancer medicines, can still control multiple myeloma (a blood cancer) while causing fewer eye-related side effects. About 200 adults whose cancer has returned or stopped respond…

This study tests a new medicine called GSK5764227 in people with advanced gastrointestinal cancers that have spread and are not removable by surgery. The goal is to see if the drug can shrink tumors and how safe it is. About 320 adults who have already tried other treatments will…

This early-stage study tests a new drug called GSK5533524 in about 97 adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow cancer growth. Researchers will also m…

This study tests whether combining two drugs, momelotinib and luspatercept, can help people with myelofibrosis go without blood transfusions for at least 12 weeks. About 68 adults who either haven't tried or have already used certain other treatments will take part. The goal is t…

This study tests a new drug called GSK5458514 in men with metastatic castration-resistant prostate cancer (mCRPC), a type of advanced prostate cancer. The goal is to check the drug's safety and how the body processes it, given alone or with other cancer treatments. About 85 men w…

This study tests an experimental drug called GSK4532990 in about 393 adults with liver inflammation (steatohepatitis) due to alcohol use. The main goals are to check safety and see if the drug can reduce liver stiffness, a sign of damage. Participants will receive either the drug…

This study tests an experimental drug called belantamab, alone or with other treatments, in people with multiple myeloma (a type of blood cancer). It includes 153 adults whose cancer has returned or not responded to prior therapies. The goal is to find safe doses and see how well…

This study tests an investigational drug called depemokimab in adults with hypereosinophilic syndrome (HES) that is not well controlled by current treatments. About 123 participants will receive either depemokimab or a placebo, added to their usual therapy, for 52 weeks. The main…

This study tests a drug called belimumab in 350 adults who have had lupus for less than 2 years and still have active symptoms despite standard treatment. The goal is to see if adding belimumab can help more people reach a low disease activity state and reduce the need for steroi…

This study tests whether a three-drug inhaler (FF/UMEC/VI) works better than a two-drug inhaler (FF/VI) for teens aged 12-17 whose asthma is not well controlled with their current medication. About 292 participants will use one of the two inhalers daily for 24 weeks. The main goa…

This study tests a new medicine called Risvutatug rezetecan (Ris-Rez) for people with relapsed small cell lung cancer. It targets a protein on cancer cells to stop growth. About 420 adults who have already tried one prior treatment will be randomly assigned to receive Ris-Rez or …

This study tests whether the drug dostarlimab can help prevent head and neck cancer from coming back after standard chemoradiation. About 864 adults with advanced but not surgically removed head and neck cancer will receive either dostarlimab or a placebo. The goal is to see if d…

This study tests a drug called momelotinib in 80 adults with low-risk myelodysplastic syndromes (MDS) who have anemia. The goal is to see if the drug can help them go without red blood cell transfusions for at least 12 weeks. The trial has two parts: first to find the best dose, …

This study tests if the drug belimumab can help adults with lung scarring (interstitial lung disease) caused by connective tissue diseases like rheumatoid arthritis or lupus. The goal is to see if it can stabilize or improve lung function and reduce symptoms like shortness of bre…

This study looks at the long-term safety and effects of the experimental drug GSK4527226 in people with early Alzheimer's disease. All 220 participants will receive the drug and must have completed a previous related study. The main focus is on side effects, including brain swell…

This early-stage study tests a new drug, GSK5471713, in adults with a type of advanced prostate cancer that has stopped responding to hormone therapy. The main goals are to check the drug's safety and find the right dose. About 54 participants will take the drug alone to see if i…

This study tests a new pneumococcal vaccine called PnMAPS30plus in healthy adults aged 50 to 64. Participants get one shot of either the new vaccine or an approved one and are followed for about six months. The goal is to see if the new vaccine is safe and helps the body make ant…

This study is the first time a new experimental malaria drug, GSK4024484, is being tested in humans. It aims to check the drug's safety in 156 healthy adults and see how food affects its absorption. Participants will receive either the drug or a placebo, and researchers will moni…

This large study in Finland is testing whether the Shingrix vaccine, which prevents shingles, can also reduce the risk of developing dementia in adults aged 76 and older. About 33,600 participants will receive either the vaccine or a placebo and be monitored for new dementia diag…

This study looks at whether a new propellant (HFA-152a) in salbutamol inhalers works as well as the current one (HFA-134a) for people with mild asthma. About 84 adults aged 18 to 65 will take single doses of the inhaler and have their lung function measured. The goal is to make s…

This early-stage study looks at how a single dose of the experimental drug efimosfermin alfa behaves in the body and whether it is safe for people with different stages of fatty liver disease. About 32 adults with liver cirrhosis will take part. The goal is to gather information,…

This study looks at new ways to predict if immunotherapy drugs (dostarlimab and pembrolizumab) will work for people with advanced lung cancer that has come back. Researchers will use blood tests, lab-grown tumor models, and special PET scans to see if these tools can forecast tre…

This early-stage study tests a single dose of efimosfermin alfa in 30 healthy adults of Chinese, Japanese, and White/European ancestry. The goal is to check the drug's safety and how the body processes it. Participants will be monitored for side effects and drug levels in the blo…

This study looks at how the body handles a single dose of bepirovirsen, a drug for hepatitis B, in people with different levels of kidney function. About 32 adults with severe or moderate kidney disease and healthy volunteers will take part. The goal is to see if kidney problems …

This study collects additional medical records from people who previously participated in asthma research. Researchers will gather up to 10 years of past and future health data from electronic records and a one-time questionnaire. The goal is to better understand how asthma devel…