New drug cocktail aims to tackle Hard-to-Treat cancers

NCT ID NCT06551142

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial is testing a new drug called Risvutatug rezetecan (Ris-Rez) in people with advanced solid tumors that have spread or cannot be removed. The study will give Ris-Rez alone or combined with other cancer drugs like chemotherapy or immunotherapy. Researchers want to see if it is safe, how the body processes it, and whether it can shrink tumors. About 845 adults with various solid tumors are being recruited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Risvutatug rezetecan (Ris-Rez), also known as GSK5764227
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
What could go wrong: This is an early phase 1 trial, so the main goal is safety, not effectiveness. The drug may not shrink tumors or could cause side effects. Results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS

Contacts and locations

Locations

GSK Investigational Site
RECRUITING

Stanford, California, 94063, United States
GSK Investigational Site
RECRUITING

Denver, Colorado, 80218, United States
GSK Investigational Site
RECRUITING

New Haven, Connecticut, 06511, United States
GSK Investigational Site
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Fort Wayne, Indiana, 46804, United States
GSK Investigational Site
RECRUITING

Boston, Massachusetts, 02114, United States
GSK Investigational Site
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Detroit, Michigan, 48201, United States
GSK Investigational Site
RECRUITING

New Brunswick, New Jersey, 08903, United States
GSK Investigational Site
RECRUITING

Myrtle Beach, South Carolina, 29572, United States
GSK Investigational Site
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Nashville, Tennessee, 37203, United States
GSK Investigational Site
RECRUITING

Austin, Texas, 78705, United States
GSK Investigational Site
RECRUITING

Dallas, Texas, 75230, United States
GSK Investigational Site
RECRUITING

San Antonio, Texas, 78229, United States
GSK Investigational Site
RECRUITING

Tyler, Texas, 75702, United States
GSK Investigational Site
RECRUITING

West Valley City, Utah, 84119, United States
GSK Investigational Site
RECRUITING

Norfolk, Virginia, 23502, United States
GSK Investigational Site
COMPLETED

Rosario, S2002, Argentina
GSK Investigational Site
RECRUITING

Viedma, R8500ACE, Argentina
GSK Investigational Site
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
GSK Investigational Site
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
GSK Investigational Site
RECRUITING

Toronto, Ontario, M5G 1X6, Canada
GSK Investigational Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
GSK Investigational Site
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
GSK Investigational Site
RECRUITING

Bordeaux, 33076, France
GSK Investigational Site
RECRUITING

Lyon, 69373, France
GSK Investigational Site
RECRUITING

Villejuif, 94805, France
GSK Investigational Site
RECRUITING

Pokfulam, Hong Kong
GSK Investigational Site
RECRUITING

Shatin, Hong Kong
GSK Investigational Site
RECRUITING

Jerusalem, 91031, Israel
GSK Investigational Site
RECRUITING

Jerusalem, 9112001, Israel
GSK Investigational Site
RECRUITING

Ramat Gan, 5266202, Israel
GSK Investigational Site
RECRUITING

Tel Aviv, 64239, Israel
GSK Investigational Site
RECRUITING

Milan, 20141, Italy
GSK Investigational Site
RECRUITING

Naples, 80131, Italy
GSK Investigational Site
RECRUITING

Roma, 00168, Italy
GSK Investigational Site
RECRUITING

Verona, 37134, Italy
GSK Investigational Site
RECRUITING

Aichi, 464-8681, Japan
GSK Investigational Site
RECRUITING

Chiba, 277-8577, Japan
GSK Investigational Site
RECRUITING

Shizuoka, 411-8777, Japan
GSK Investigational Site
RECRUITING

Tokyo, 104-0045, Japan
GSK Investigational Site
RECRUITING

Tokyo, 135-8550, Japan
GSK Investigational Site
RECRUITING

Panama City, Panama
GSK Investigational Site
RECRUITING

Panama City, Panama
GSK Investigational Site
RECRUITING

Gyeonggi-do, 10408, South Korea
GSK Investigational Site
RECRUITING

Seoul, 03080, South Korea
GSK Investigational Site
RECRUITING

Seoul, 03722, South Korea
GSK Investigational Site
RECRUITING

Seoul, 135-710, South Korea
GSK Investigational Site
RECRUITING

Badajoz, 06080, Spain
GSK Investigational Site
RECRUITING

Barcelona, 08035, Spain
GSK Investigational Site
RECRUITING

Barcelona, 08036, Spain
GSK Investigational Site
RECRUITING

Madrid, 28034, Spain
GSK Investigational Site
RECRUITING

Madrid, 28040, Spain
GSK Investigational Site
RECRUITING

Madrid, 28041, Spain
GSK Investigational Site
RECRUITING

Málaga, 29010, Spain
GSK Investigational Site
RECRUITING

Valencia, 46026, Spain
GSK Investigational Site
RECRUITING

Zaragoza, 50009, Spain
GSK Investigational Site
RECRUITING

Changhua, 500, Taiwan
GSK Investigational Site
RECRUITING

Kaohsiung City, 83301, Taiwan
GSK Investigational Site
RECRUITING

Taichung, 40447, Taiwan
GSK Investigational Site
RECRUITING

Tainan, 704, Taiwan
GSK Investigational Site
RECRUITING

Taipei, 10002, Taiwan
GSK Investigational Site
RECRUITING

Taipei, 11217, Taiwan
GSK Investigational Site
RECRUITING

Edinburgh, EH4 2XU, United Kingdom
GSK Investigational Site
RECRUITING

Glasgow, G12 0YN, United Kingdom
GSK Investigational Site
RECRUITING

London, W1G 6AD, United Kingdom
GSK Investigational Site
RECRUITING

London, WC1E 6AG, United Kingdom
GSK Investigational Site
RECRUITING

Manchester, M20 4BX, United Kingdom
GSK Investigational Site
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

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