Experimental cancer drug enters human testing

NCT ID NCT06431594

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests an experimental drug called mocertatug rezetecan in 675 adults with advanced solid tumors that have not responded to standard treatments. The drug is designed to deliver a toxin directly to cancer cells. The main goals are to check safety, find the right dose, and see if tumors shrink.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mocertatug rezetecan (an experimental antibody-drug conjugate that delivers a toxin to cancer cells)
What this could lead to: If successful, this could point toward a new treatment option for people with advanced solid tumors that have not responded to standard therapies.
What could go wrong: This is an early Phase 1 trial focused on safety and dosing, so it is too soon to know if the drug will work. Side effects from the toxin or antibody may limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial cancer fallopian tube cancer neoplasm ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS SOLID TUMORS

Contacts and locations

Locations

GSK Investigational Site
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Birmingham, Alabama, 35294, United States
GSK Investigational Site
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Fountain Valley, California, 92708, United States
GSK Investigational Site
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Santa Rosa, California, 95403, United States
GSK Investigational Site
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Lake Mary, Florida, 32746, United States
GSK Investigational Site
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Orlando, Florida, 32827, United States
GSK Investigational Site
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Fairway, Kansas, 66205, United States
GSK Investigational Site
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Boston, Massachusetts, 02114, United States
GSK Investigational Site
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Boston, Massachusetts, 02215, United States
GSK Investigational Site
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Detroit, Michigan, 48201, United States
GSK Investigational Site
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Grand Rapids, Michigan, 49546, United States
GSK Investigational Site
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Minneapolis, Minnesota, 55455, United States
GSK Investigational Site
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Mineola, New York, 11501, United States
GSK Investigational Site
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New York, New York, 10016, United States
GSK Investigational Site
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Portland, Oregon, 97213, United States
GSK Investigational Site
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Nashville, Tennessee, 37203, United States
GSK Investigational Site
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Dallas, Texas, 75230, United States
GSK Investigational Site
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West Valley City, Utah, 84119, United States
GSK Investigational Site
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Seattle, Washington, 98104, United States
GSK Investigational Site
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Cipoletti Rio Negro, R8324CVE, Argentina
GSK Investigational Site
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Ciudad de Buenos Aires, 1118, Argentina
GSK Investigational Site
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La Plata, B1900AVG, Argentina
GSK Investigational Site
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Rosario, S2002, Argentina
GSK Investigational Site
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Blacktown, New South Wales, 2148, Australia
GSK Investigational Site
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Macquarie University, New South Wales, 2109, Australia
GSK Investigational Site
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Leuven, 3000, Belgium
GSK Investigational Site
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Barretos, 14784-400, Brazil
GSK Investigational Site
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Goiânia, 74605-070, Brazil
GSK Investigational Site
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Rio de Janeiro, 20220-410, Brazil
GSK Investigational Site
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Ottawa, Ontario, K1H 8L6, Canada
GSK Investigational Site
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Toronto, Ontario, M4N 3M5, Canada
GSK Investigational Site
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Toronto, Ontario, M5G 2M9, Canada
GSK Investigational Site
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Montreal, Quebec, H2X 0A9, Canada
GSK Investigational Site
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Montreal, Quebec, H3T 1E2, Canada
GSK Investigational Site
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Helsinki, 00180, Finland
GSK Investigational Site
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Helsinki, 00290, Finland
GSK Investigational Site
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Tampere, 33520, Finland
GSK Investigational Site
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Lyon, 69373, France
GSK Investigational Site
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Saint-Herblain, 44805, France
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Villejuif, 94805, France
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Aviano PN, 33081, Italy
GSK Investigational Site
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Milan, 20141, Italy
GSK Investigational Site
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Milan, 20159, Italy
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Naples, 80131, Italy
GSK Investigational Site
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Roma, 00168, Italy
GSK Investigational Site
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Saitama, 350-1298, Japan
GSK Investigational Site
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Shizuoka, 411-8777, Japan
GSK Investigational Site
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Tokyo, 135-8550, Japan
GSK Investigational Site
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Amsterdam, 1066 CX, Netherlands
GSK Investigational Site
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Gyeonggi-do, 10408, South Korea
GSK Investigational Site
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Seoul, 03080, South Korea
GSK Investigational Site
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Seoul, 03722, South Korea
GSK Investigational Site
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Seoul, 06351, South Korea
GSK Investigational Site
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Barcelona, 08035, Spain
GSK Investigational Site
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Córdoba, 14004, Spain
GSK Investigational Site
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Girona, 17007, Spain
GSK Investigational Site
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Madrid, 28027, Spain
GSK Investigational Site
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Madrid, 28034, Spain
GSK Investigational Site
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Madrid, 28040, Spain
GSK Investigational Site
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Madrid, 28046, Spain
GSK Investigational Site
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Pozuelo de AlarcOn Madr, 28223, Spain
GSK Investigational Site
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Stockholm, 17164, Sweden
GSK Investigational Site
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Uppsala, SE-751 85, Sweden
GSK Investigational Site
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Cambridge, CB2 0QQ, United Kingdom
GSK Investigational Site
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London, NW1 2PG, United Kingdom
GSK Investigational Site
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London, W1G 6AD, United Kingdom

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