New pill aims to shrink aggressive tumors with unique DNA flaws
NCT ID NCT07213609
First seen Nov 01, 2025 · Last updated Jun 07, 2026 · Updated 35 times
Summary
This study tests an experimental oral drug, GSK5460025, alone or with other cancer drugs, in adults whose solid tumors have specific genetic changes (dMMR or MSI-H) that make them harder to treat. The goal is to see if the drug can shrink tumors and to check its safety and how the body processes it. About 47 participants will take part in this early-phase trial.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
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Locations
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GSK Investigational Site
RECRUITINGDetroit, Michigan, 48201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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GSK Investigational Site
RECRUITINGCanton, Ohio, 44718, United States
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Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGNashville, Tennessee, 37203, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGHamilton, Ontario, L8V 5C2, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGToronto, Ontario, M5G 2M9, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGMontreal, Quebec, H4A 3J1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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GSK Investigational Site
RECRUITINGChiba, 277-8577, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGOsaka, 573-1191, Japan
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGTokyo, 104-0045, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGTokyo, 135-8550, Japan
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGAmsterdam, 1066 CX, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGMadrid, 28041, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGMadrid, 28050, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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