NEOPLASMS

This early-phase trial tests a new oral drug, Aza-TdC, in adults with advanced solid tumors that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can turn on genes that may slow tumor growth. Participants take the drug in 21-day cycle…

This study offers young female cancer patients a way to preserve their fertility by freezing a piece of their ovary before cancer treatment starts. Later, when they are ready, the tissue can be transplanted back to help them try for a baby. The goal is to make this service availa…

This early-stage study tests a new treatment called IL-5 CAR-T cell therapy for people with a rare and hard-to-treat blood cancer called eosinophilic leukemia. The therapy uses a patient's own immune cells, modified in a lab to target and attack cancer cells. The main goals are t…

This study tests whether two drugs, nilotinib and paclitaxel, can shrink or stop rare cancers that have not responded to standard treatments. About 82 adults with rare advanced cancers will take nilotinib pills twice daily and receive weekly paclitaxel infusions in 28-day cycles.…

This early-stage study tests an experimental drug called GSK5733584 in adults with advanced solid tumors that have not responded to standard treatments. The main goals are to check the drug's safety and find the best dose. Researchers will also see if the drug can shrink tumors. …

This early-stage study tests a new drug called AST-201 in about 70 adults with advanced solid tumors that have a protein called GPC3. The main goal is to check the drug's safety and find the right dose. Researchers will also measure how the drug moves through the body and look fo…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. JV-394 uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goa…

This early-phase study tests a virus (JNJ-87704916) that is injected directly into tumors to kill cancer cells. It is being tested alone and with another drug (cetrelimab) in people with advanced solid tumors who have run out of standard treatments. The main goals are to check sa…

This study looks at how well the drug vorolanib works for people with advanced kidney cancer that cannot be removed by surgery or has spread. It is for patients who need a second treatment after their first one stopped working. The study will track how long the cancer stays under…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This early-stage study tests a new drug, RO7673396, in people with advanced solid tumors that have RAS mutations. The goal is to find a safe dose and see if the drug can shrink tumors when used alone or with other cancer treatments. About 405 adults with incurable cancers will ta…

This study tests a new drug called pocenbrodib, given alone or with another drug (darolutamide), in people with metastatic castration-resistant prostate cancer (mCRPC) that has spread and stopped responding to standard hormone therapy. The goal is to find safe and effective doses…

This study tests whether adding a focused ultrasound device (NaviFUS) to the standard drug Avastin helps people with recurrent glioblastoma (a type of aggressive brain cancer) live longer without their cancer growing. About 32 adults whose cancer returned after standard treatment…

This early-phase study is testing a new chemotherapy drug (JNJ-1761981) that is injected directly into tumors in people with advanced solid tumors that have not responded to standard treatments. The goal is to find a safe and effective dose, and to see if it can shrink the treate…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has worsened after first treatment. About 78 adults will be randomly assigned to one of the two gro…

This early-stage study tests a new drug, JNJ-88549968, in about 220 adults with certain blood cancers (myelofibrosis or essential thrombocythemia) caused by a CALR gene mutation. The drug is designed to help the immune system attack cancer cells. The main goals are to check safet…

This early-stage trial tests a new drug called nenocorilant combined with an immunotherapy (nivolumab) in people with advanced solid tumors that have not responded to standard treatments. The goal is to find the safest and most effective dose and see if the combination can shrink…

This early-phase study tests a new drug called JNJ-87890387 in people with advanced solid tumors that have spread or cannot be removed. The drug is designed to help the immune system attack cancer cells. The main goals are to find a safe dose and to check for side effects. About …

This study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. It is given together with standard treatments to people with advanced solid tumors, such as colorectal or prostate cancer. The main goals…

This early-phase study tests whether a specially engineered virus called G207 is safe for children whose cerebellar brain tumors have come back or not responded to standard treatments. Up to 24 children aged 3 to 21 will receive the virus directly into the tumor, along with a low…

This early-stage study tests an experimental pill called ABSK021 in people with advanced solid tumors (including a rare joint tumor called TGCT) who have run out of standard options. The main goal is to check safety and find the best dose, while also seeing if the drug can shrink…

This early-stage study tests a new drug called GSK5533524, alone or with other cancer medicines, in about 97 adults whose advanced solid tumors have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can shrink tumors or slow can…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This study tests whether giving two immunotherapy drugs (nivolumab with or without relatlimab) before surgery can eliminate bladder cancer completely, allowing some patients to avoid bladder removal. About 90 adults with stage II-IIIa bladder cancer that has spread into the muscl…

This trial is a master protocol that allows researchers to test several new cancer drugs in children and young adults more efficiently. About 105 participants with different types of cancer will join, and each will receive a drug tailored to their disease. The goal is to see how …

This study tests an experimental oral drug, GSK5460025, alone or with other cancer drugs, in adults whose solid tumors have specific genetic changes (dMMR or MSI-H) that make them harder to treat. The goal is to see if the drug can shrink tumors and to check its safety and how th…

This early-stage study tests whether combining a standard brain cancer drug (bevacizumab) with focused ultrasound can safely treat recurrent glioblastoma, an aggressive brain tumor. About 10 adults whose cancer has returned after standard therapy will receive the combination. The…

This early-stage study tests an experimental drug called GSK5764227 (Risvutatug rezetecan) in about 845 adults with advanced solid tumors that have spread or are hard to treat. The drug is given alone or with other cancer medicines to see if it is safe, tolerable, and can shrink …

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study offers female cancer patients aged 0-35 the chance to freeze a piece of their ovary before cancer treatment, then have it transplanted back later. The goal is to help them preserve their ability to have children. Researchers will monitor surgical safety and pregnancy r…

This study aims to see if a new PET/CT tracer called [18F]RCCB6 can better detect kidney cancer, especially the most common type. About 300 adults with known or suspected kidney cancer will receive the tracer and undergo imaging. Researchers will compare its accuracy to standard …

This early-stage study tests a new radioactive dye called [18F]LY4214835 to see if it is safe and how well it lights up tumors on scans. About 41 healthy adults and people with cancer will receive one injection and be followed for 35 days. The goal is to improve cancer imaging, n…

This study looks at whether adding a special dye to mammograms every two years helps find breast cancer earlier in women who have already had it. About 1,500 women will get both a standard 3D mammogram and a contrast-enhanced mammogram. The goal is to see if the new method catche…

This study is testing whether a special massage technique called manual lymph drainage can help reduce swelling in the face and neck caused by radiation therapy for head and neck cancer. The study will include 40 people who have completed radiation treatment. The main goal is to …

This study tests whether a specially designed video game can help people aged 60 and older manage nausea and vomiting caused by chemotherapy. About 610 participants will be randomly assigned to play the game or receive standard care. Researchers will track how severe their sympto…

This study tests whether a special team of doctors, nurses, and other experts can help people aged 75 and older with digestive cancer complete more of their planned chemotherapy or targeted therapy. About 144 participants will either receive this extra support or standard care. T…

This study tests a program called ENABLE-SG that provides coaching and support to people recently diagnosed with advanced cancer and their caregivers. The goal is to help them cope better and improve quality of life early on, rather than waiting until symptoms become severe. Abou…

This study tests whether eating all food within a 10-hour window each day can reduce severe, long-lasting fatigue in blood cancer survivors. About 96 adults who finished cancer treatment at least 2 months ago will either follow this time-restricted eating plan or receive standard…

This study tests a nurse-led program to help cancer patients be more physically active while receiving chemotherapy. About 50 adults with cancer will take part. The program includes activity plans, safety checks, and support tools. The goal is to see if this approach is practical…

This study tests an experimental drug called LY3537021 to see if it can better control nausea and vomiting caused by chemotherapy in adults with cancer. About 204 participants will receive either the drug or a placebo, and researchers will track who has no vomiting and does not n…

This study tests whether a personalized exercise program done at home with a trainer via video can improve quality of life and reduce common side effects like fatigue, anxiety, and nerve pain in cancer survivors. About 350 adults who finished cancer treatment within the past year…

This study collects and analyzes information from 40,000 patients treated with radiation therapy for cancer. The goal is to understand what works best and how to reduce side effects. No new treatments are being tested—just careful tracking of real-world results to improve future …

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a person's past, current, and future studies. The goal is to better understand…

This study aims to find immune system markers that can predict how well a cancer patient responds to radiotherapy. Researchers will analyze blood samples from 40 adults who have already completed radiotherapy without major side effects. The goal is to personalize future cancer tr…

This study is testing a new smartphone app designed to help cancer patients remember to take their oral anticancer medications and report any side effects. The app also helps patients communicate with their care team and find support for financial or social needs. Researchers wil…

This study collects tissue and fluid samples from up to 5,000 cancer patients to help researchers learn more about cancer and develop new tests and treatments. Samples are taken from routine procedures or from extra biopsies done just for research. The goal is to build a resource…

This study tests whether remote health education workshops are practical and helpful for adolescents and young adults (ages 15-25) with cancer in France. About 48 participants will take part in three online sessions designed to help them manage daily life with cancer. The goal is…

This study looks at whether patients can move around freely after receiving the injection for a PET scan without hurting the quality of the images. Normally, patients must rest quietly for an hour before the scan. The study will compare image quality between those who rest and th…

This study looks at new ways to screen for anal precancer in people at high risk, such as those with weakened immune systems. Researchers will test different screening methods to see which ones work best at finding early signs of cancer. They will also study genetic and immune fa…

This study aims to learn more about Li-Fraumeni syndrome (LFS), a genetic condition that raises the risk of several cancers. Researchers will study up to 5,000 people with LFS or related cancer histories to find new genes, understand how the TP53 gene works, and identify factors …

This study looks at different scoring systems to see which best predicts whether a person will need intensive care after cancer surgery. Researchers will follow 500 adults having cancer surgery and compare the accuracy of these tools. The goal is to help doctors plan better and u…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study watches how immunotherapy affects physical fitness and daily life in 67 adults with advanced solid cancers. Participants do fitness tests and fill out questionnaires before starting treatment and again 12 weeks later. Researchers also take blood samples and follow heal…

This study follows children and adults who have already received gene-modified T cells in a previous trial. Researchers will watch for long-term side effects, check if the modified cells persist, and monitor overall health. No new treatment is given—the goal is to understand the …

This study is creating a digital program to help East Asian immigrants who have cancer start conversations with their family about future medical care. Researchers will test how easy and acceptable the tool is for patients and religious leaders. The goal is to make advance care p…

This study follows people who have already received ADP adoptive cell therapy for cancer. The goal is to monitor their health for up to 15 years to check for any delayed side effects. About 250 participants will be observed, but no new treatment is given.

This study aims to create a computer-based tool that can predict which cancer patients are at higher risk for heart problems from certain chemotherapy or targeted therapies. Researchers will collect data from 600 patients over one year and use machine learning to build a risk sco…

This study is enrolling 1 million adults aged 18 and older to track their health over many years, possibly for life. Researchers will collect health measurements and follow participants to see who develops diseases or dies, and why. The goal is to create better ways to predict ag…

This study looks at proteins and other markers in the blood of 2000 people with or suspected of having cancer. The goal is to find markers that help doctors diagnose cancer, choose the right treatments, and predict if the cancer will come back. Participants must be 18 or older an…

This study collects tumor samples and medical information from 1,500 people with pancreatic cancer. The goal is to build a large biobank that researchers can use to better understand the disease and develop new treatments. Participants undergo standard diagnostic procedures, and …

This study is testing a new online learning tool designed to help people with cancer improve their ability to find and understand health information on the internet. About 660 cancer patients will take part, and they will be randomly assigned to use the online tool, read a PDF wi…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…

This study is creating a large database of 2,000 people with metastatic liver cancer (cancer that has spread to the liver from another part of the body). Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and improve…

This study collects blood, bone marrow, urine, and tissue samples from people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, i…