NEOPLASMS

This early-stage study tested a combination of two drugs (niraparib and dostarlimab) in children and teens aged 6 months to 18 years whose solid tumors had come back or did not respond to treatment. The main goals were to find safe doses and see how the drugs worked in the body. …

This early-phase study tested a drug called EO-3021 in 88 adults with advanced stomach or other solid tumors that have a specific marker (CLDN18.2). The goal was to check safety and see if tumors shrink. The study was stopped early, but the results help researchers understand how…

This early-stage study tested a new drug (PF-07820435) alone or with another drug (sasanlimab) in 9 people with advanced solid tumors like lung, melanoma, and kidney cancer. The goal was to check safety and find the right dose. The study was terminated early, so results are limit…

This study tested a targeted pill called pralsetinib against standard chemotherapy in people with a rare type of advanced lung cancer driven by a RET gene fusion. The goal was to see if pralsetinib could delay cancer growth better than chemo. The trial was stopped early, but resu…

This early-stage study tested a new drug (PF-07826390) alone or with another drug (sasanlimab) in 10 people with advanced solid tumors like lung, colon, or kidney cancer. The main goals were to check safety and find the right dose. The study was stopped early, so results are limi…

This study tested a new drug (NKT2152) combined with two other medications (palbociclib and sasanlimab) in people with advanced clear cell kidney cancer that had worsened after prior treatments. The goal was to see if the combination was safe and could shrink tumors. The trial wa…

This study tested an experimental drug called OC-001, either by itself or together with avelumab (an immunotherapy), in people with advanced cancers that had spread. The goal was to check safety and how the drug moves through the body. The study was stopped early, and only 73 peo…

This study tested a new drug called modakafusp alfa, alone or with pembrolizumab, in 45 adults with advanced solid tumors or melanoma that couldn't be removed by surgery. The main goals were to check safety and find the best dose. The study was terminated early, so results are li…

This study compared two ways of giving palliative radiotherapy to people with cancer that has spread to the bones. The goal was to see which method better controls nausea and vomiting caused by radiation, while also managing pain. About 160 adults with bone metastases took part, …

This study aimed to see how moderate or severe liver problems change the way the body handles the blood cancer drug oral azacitidine (Onureg). It planned to compare drug levels in people with and without liver issues. However, the study was stopped early after only 2 participants…