NEOPLASMS

This early-stage study tests whether combining a standard drug (bevacizumab) with a device that uses sound waves (NaviFUS) can safely treat recurrent glioblastoma, an aggressive brain cancer. Ten adults whose tumor has returned after standard therapy will receive the combination.…

This early-stage study is testing an experimental drug called JNJ-88549968 in people with certain blood cancers (myeloproliferative neoplasms) that have a specific genetic change (CALR mutation). The main goals are to check the drug's safety and find the best dose. About 220 adul…

This early-phase study tests a new medicine, GSK5764227, that delivers a toxin directly to cancer cells to destroy them while leaving healthy cells alone. About 84 adults with advanced colorectal or prostate cancer will receive the drug alongside standard treatments. The main goa…

This early-stage study is testing a new treatment called JNJ-87704916, a virus designed to infect and destroy cancer cells. It is given as an injection directly into the tumor, either alone or with another drug (cetrelimab). The study aims to find the safest dose and see if it sh…

This study tests whether adding the experimental drug SLC-3010 to the standard drug axitinib works better than axitinib alone for people with advanced clear cell kidney cancer that has already been treated once. About 78 participants will be randomly assigned to one of the two tr…

This study enrolls people with cancer who are already participating in other studies at the National Cancer Institute. Researchers will collect and link medical records and research samples from all of a participant's past, current, and future studies. The goal is to better under…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy using a special machine called the MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to see if this technology improves survival, tumor control, and qualit…