NEOPLASMS

This small pilot study tested a new approach for people with recurrent glioblastoma, an aggressive brain cancer that has come back after standard treatments. Six adults received a combination of focused ultrasound (NaviFUS) and the standard drug bevacizumab. The goal was to see i…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This early-stage study tested a new drug called MRX-2843 in 42 adults with advanced solid tumors that had come back or stopped responding to standard treatments. The main goal was to check the drug's safety and find the best dose. Researchers monitored side effects and how the dr…

This early-phase trial tested a new drug called BI 836880 in 24 people with advanced solid tumors that had stopped responding to standard treatments. The main goal was to find the safest dose and check for side effects. Researchers also looked at how the drug moves through the bo…

This study tested a new radioactive drug, 177Lu-NeoB, in 35 adults with advanced solid tumors that have a specific marker (GRPR). The goal was to check safety, find the best dose, and see if it shrinks tumors. It is an early-stage trial, so it focuses on safety and dosing, not a …

This study tested a combination of two experimental drugs, brigimadlin and ezabenlimab, in adults with advanced solid tumors (cancers that have spread). The first part found the safest dose, and the second part is checking if the combination can shrink tumors. 119 people took par…

This early-stage study tested several combinations of cancer drugs in 60 people with advanced or metastatic cancer. The main goal was to find safe doses for future studies. The trial looked at different drug mixes, including niraparib, TSR-042, bevacizumab, and various chemothera…

This early-phase study tested a new drug called LY3039478 in 247 adults with advanced or metastatic cancer, including lymphoma. The main goals were to find a safe dose and see if the drug could shrink tumors. While the drug showed some activity, it is not a cure and requires furt…

This early-stage trial tested a new drug called vibostolimab, either alone or combined with other cancer drugs, in 474 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the dr…

This early-phase study tested a new immunotherapy drug (BI 754091) alone or combined with another drug (BI 754111) in 146 Asian patients with advanced solid tumors like stomach, liver, and lung cancer. The main goals were to find safe doses and check for side effects. Researchers…

This early-phase study tested a new drug called MK-4464, given alone or with another drug (pembrolizumab), in 64 people with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety, find the right dose, and see how the drug moves t…

This study tested two experimental drugs (BI 754111 and BI 754091) that help the immune system attack cancer. It included 172 adults with advanced solid tumors, including non-small cell lung cancer that had returned after prior treatment. The first part found the safest dose, and…

This early-phase trial tested two experimental drugs, FdCyd and THU, taken by mouth to treat advanced solid tumors that no longer respond to standard therapies. The study involved 59 adults and aimed to find a safe dose and schedule. The drugs work by changing how cancer cells us…

This study tested a combination of two experimental drugs (BI 836880 and ezabenlimab) in 252 adults with advanced non-squamous lung cancer and other solid tumors. The first part found the safest dose; the second part checked if the combo could shrink tumors. Participants received…

This early-phase study tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. The main goal was to find the safest dose and check fo…

This early-phase study tested a new treatment called RD13-02, which uses a patient's own immune cells modified to attack cancer cells with a specific marker (CD7). It included 2 people with blood cancers that had come back or stopped responding to standard treatments. The main go…

This study tested a new drug called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. In the first part, the drug was given alone to find the safest dose. In the second part, it was given with or without another drug (ruxolitinib) to see if it…

This study tested a new cancer drug called brigimadlin in 266 adults with advanced solid tumors that had spread or were not responding to standard treatments. The goal was to find the safest dose and see if the drug could shrink tumors. Participants took the drug as a tablet eith…

This study looked at the long-term safety of an oral chemotherapy drug (azacitidine) in 5 adults with blood cancers who had already taken it in earlier studies. Researchers tracked side effects and survival to see if continued treatment was safe. The goal was to monitor risks, no…

This early-phase trial tested a new drug called BI 836880 in 29 adults with advanced solid tumors that had not responded to standard treatments. The main goal was to find a safe dose and check for side effects. The study was not designed to cure cancer, but to gather information …

This early-phase study tested an experimental drug called MK-4830, either by itself or combined with other cancer therapies like pembrolizumab, in 470 people with advanced solid tumors. The main goals were to check safety, find the right dose, and see if tumors shrank. The study …

This early-phase study tested a new drug (BI 836880) alone or combined with another drug (BI 754091) in 21 Japanese adults with advanced solid tumors. The main goal was to find the safest dose and check for side effects. This is not a cure, but a step toward better control of adv…

This early-phase trial tested a new drug called BI 754091 in 110 adults with advanced solid tumours that could not be removed by surgery or had spread. The main goals were to find the safest dose and check for side effects. Researchers also looked for signs that the drug might sh…

This early-phase study tested an experimental drug called JNJ-70218902 in 82 adults with advanced solid tumors that had stopped responding to standard treatments. The drug works by redirecting the body's T cells to attack cancer cells. The main goals were to find the safest dose …

This early-stage study tested a new drug called JNJ-64619178 in 114 people with advanced cancers, including lymphoma, solid tumors, and myelodysplastic syndromes. The main goal was to find the safest dose and check for side effects. The drug works by blocking a protein that helps…

This study tested a device called PointCheck that uses light to check for severe neutropenia (dangerously low white blood cells) in cancer patients without needing a blood draw. 81 adults with blood or breast cancer getting chemotherapy were enrolled. The main goal was to see if …

This study tested two advanced imaging techniques (high-resolution MRI and PSMA PET-MRI) to see if they could find prostate cancers that standard MRI might miss. 62 men who were considering focal HIFU therapy or prostate removal took part. The goal was to improve cancer detection…

This study tested a special pad (PadKit™) worn for 4-6 hours to collect cells shed from the uterus. Researchers checked if the pad could tell normal cells from abnormal or cancerous ones. 80 women scheduled for surgery took part. The goal was to see if this comfortable, at-home m…

This study tested whether a mobile app could help cancer patients recognize and report treatment side effects more effectively. 222 adults receiving chemotherapy or radiation therapy used the app to track symptoms and share them with their doctors. The goal was to improve patient…

This study looked at whether a mix of in-person and online physiotherapy sessions is practical for children aged 4-17 with acute lymphoblastic leukemia. Ten children and their families tried the program, which used an online platform for exercises and tracking. The goal was to se…

This study looked at whether a program called expressive helping—where people write or record their feelings—is helpful for Chinese-speaking cancer patients and survivors. About 60 adults with any type of cancer took part. The goal was to see if the program was easy to use and if…

This study tested a financial navigation program for 258 cancer patients in rural and non-rural North Carolina. The goal was to see if personalized help with costs could reduce financial stress and improve quality of life. Participants had high financial distress and received gui…

This study looked at over 200,000 adults with obesity and type 2 diabetes to see if the type of diabetes medication they took before a cancer diagnosis affected their survival and complications after cancer. Researchers compared GLP-1 receptor agonists (like Ozempic) with other d…

This study looked at whether giving antibiotics before placing a kidney tube (nephrostomy) in cancer patients with a blocked urinary tract reduces the chance of a urinary tract infection. Researchers reviewed records of 320 cancer patients who had this procedure. The goal was to …

This study looked at how often cancer patients who are also at risk for bleeding develop dangerous blood clots. Researchers followed 700 hospitalized cancer patients to track clot rates and understand how to better manage these situations. The goal was to gather information to im…

This study looked at 116 cancer patients to see how their eating habits changed during treatment, especially their ability to stick with the Mediterranean diet. Researchers measured taste and smell changes caused by chemotherapy and linked them to diet quality. The goal is to und…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study looked at 330 older adults (65+) who had cancer surgery to see if low albumin (a protein in the blood) before surgery led to more complications, longer hospital stays, or more ICU visits. Researchers compared those with low albumin to those with normal levels. The goal…

This study looked at 33 patients who had both cancer and a bleeding disorder called immune thrombocytopenia (ITP). The goal was to see if cancer cells trick the immune system into attacking the body's own platelets. Researchers found that treating the cancer often helped the ITP …

This study tested a mobile program designed to help young adult cancer survivors (ages 18-39) eat healthier and be more physically active. 72 survivors joined the pilot trial, which used a phone-based approach to encourage better habits. The main goal was to see if the program wa…

This study tested whether machine learning can analyze facial expressions and voice recordings to measure pain in people with cancer. 83 participants, aged 12 and older, recorded short videos at clinic visits and at home over about 3 months. The goal was to see if this technology…