Experimental pill combo shows promise for Hard-to-Treat cancers

NCT ID NCT01534598

First seen Nov 21, 2025 · Last updated Apr 23, 2026 · Updated 14 times

Summary

This early-phase trial tested two experimental drugs taken by mouth—FdCyd and THU—in 59 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see if the combination could control tumor growth. Participants took the drugs for three days in the first two weeks of each 21-day cycle, continuing as long as their cancer stayed stable and side effects were manageable.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

  • Penn State

    Hershey, Pennsylvania, 17033, United States

  • UC Davis Cancer Center

    Sacramento, California, 95817, United States

  • USC Norris Cancer Center

    Los Angeles, California, 90033, United States

  • University of Pittsburgh Cancer Institute

    Pittsburgh, Pennsylvania, 15232, United States

Conditions

Explore the condition pages connected to this study.