New master trial aims to speed up cancer treatments for kids

NCT ID NCT05999994

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This trial tests several cancer drugs in children and young adults with solid tumors. It uses a master protocol to test different drug combinations more efficiently. About 105 participants will receive one of eight drugs, including ramucirumab, cyclophosphamide, and others. The goal is to find which treatments work best for different cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ramucirumab, Cyclophosphamide, Vinorelbine, Gemcitabine, Docetaxel, Abemaciclib, Irinotecan, Temozolomide
What this could lead to: If successful, this could identify effective drug combinations for different childhood cancers, leading to better treatment options.
What could go wrong: This is an early-phase trial with only 105 participants, so results may not apply to all patients. The drugs may cause side effects or not work as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm primary interstitial lung disease specific to childhood

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADOLESCENT CHILD NEOPLASMS

Contacts and locations

Locations

Ann & Robert H Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Azienda Ospedaliera Di Padova
RECRUITING

Padova, 35128, Italy
C.S. Mott Children's Hospital
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48109, United States
Centre Leon Berard
NOT_YET_RECRUITING

Lyon, 69008, France
Centre Leon Berard
RECRUITING

Lyon, 69008, France
Children's Healthcare of Atlanta, Inc. at Egleston
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Children's Hospital of Colorado
RECRUITING

Denver, Colorado, 80218, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States
Children's Hospital of Philadelphia
COMPLETED

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Childrens Hospital of Alabama
NOT_YET_RECRUITING

Birmingham, Alabama, 35233, United States
Childrens Hospital of Los Angeles
COMPLETED

Los Angeles, California, 90027, United States
Chris O'Brien Lifehouse
COMPLETED

Camperdown, 2050, Australia
Cook Children's Hospital
ACTIVE_NOT_RECRUITING

Fort Worth, Texas, 76104-2724, United States
Dana-Farber Cancer Institute
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy
Golisano Children's Hospital of Southwest Florida
RECRUITING

Fort Myers, Florida, 33908, United States
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
Hospital Infantil Universitario Niño Jesús
RECRUITING

Madrid, 28009, Spain
Hospital Sant Joan de Déu
RECRUITING

Esplugues de Llobregat, 8950, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, 46026, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain
Hospital Universitario de Canarias
RECRUITING

San Cristóbal de La Laguna, 38320, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08025, Spain
Hyogo Prefectural Kobe Children's Hospital
RECRUITING

Kobe, 650-0047, Japan
IRCCS Istituto Ortopedico Rizzoli
RECRUITING

Bologna, 40136, Italy
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
RECRUITING

Bordeaux, 33076, France
Institut Curie
NOT_YET_RECRUITING

Paris, 75248, France
Istituto Clinico Humanitas
RECRUITING

Rozzano, 20089, Italy
Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
RECRUITING

Candiolo, 10060, Italy
Kyushu University Hospital
RECRUITING

Fukuoka, 812-8582, Japan
Leids Universitair Medisch Centrum
RECRUITING

Leiden, 2333 ZA, Netherlands
Lifespan Cancer Institute
RECRUITING

Providence, Rhode Island, 02906, United States
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
National Cancer Center Hospital
RECRUITING

Chūōku, 104-0045, Japan
Nationwide Children's Hosp
RECRUITING

Columbus, Ohio, 43205-2664, United States
Oregon Health and Science University
NOT_YET_RECRUITING

Portland, Oregon, 97201, United States
Ospedale Bambino Gesu
RECRUITING

Roma, 00165, Italy
Peter MacCallum Cancer Centre
COMPLETED

Melbourne, 3000, Australia
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Prinses Maxima Centrum
RECRUITING

Utrecht, 3584 CS, Netherlands
Riley Hospital for Children
ACTIVE_NOT_RECRUITING

Indianapolis, Indiana, 46202-5225, United States
Royal Children's Hospital
COMPLETED

Melbourne, 3052, Australia
Royal Manchester Children's Hospital
RECRUITING

Manchester, M13 9WL, United Kingdom
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
Seattle Children's Hospital Research Foundation
RECRUITING

Seattle, Washington, 98105, United States
Texas Childrens Hospital
NOT_YET_RECRUITING

Houston, Texas, 77025, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
UCL- Saint Luc
RECRUITING

Brussels, 1200, Belgium
UCLA Medical Center
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
UPMC Children's Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Freiburg
RECRUITING

Freiburg im Breisgau, 79106, Germany
Universitaetsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20251, Germany
Universitair Ziekenhuis Gent
COMPLETED

Ghent, 9000, Belgium
University College Hospital - London
RECRUITING

London, NW1 2PG, United Kingdom
University of Minnesota Hospital
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Texas Southwestern Medical Center at Dallas
RECRUITING

Dallas, Texas, 75390-9063, United States
Washington University Medical School
COMPLETED

St Louis, Missouri, 63110, United States

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