ADOLESCENT

This study creates a common framework to test multiple new cancer drugs in children and young adults more efficiently. About 105 participants with measurable or evaluable tumors will join, and their continued participation depends on how long the treatment helps. The goal is to s…

This study tests whether a new drug called Telpegfilgrastim, given as a single shot, works better than the standard daily Filgrastim to prevent low white blood cell counts (neutropenia) in children and young adults aged 6-24 with solid tumors. About 132 participants will receive …

This study tests whether replacing two standard chemotherapy drugs with brentuximab vedotin can help more children and young adults (ages 2 to 34) with newly diagnosed Hodgkin lymphoma achieve a complete response early in treatment. The goal is to reduce the need for radiation th…

This study tests whether giving tuberculosis (TB) preventive medicine right away to children and teens who live with a TB patient can stop them from getting infected. About 647 kids aged 5 to 17 will be split into two groups: one gets the medicine immediately, the other gets stan…

This study tests whether a pectoral nerve block given before surgery can lower the amount of morphine needed after heart device implantation in children aged 3 to 18. Half the children will get the nerve block plus standard numbing medicine, while the other half gets only the sta…

This study tests if a gentle, non-invasive brain stimulation called HD-tDCS can reduce depression in 100 teens (ages 12-18) with bipolar disorder. Half get real stimulation, half get a fake version, and researchers track mood changes and brain activity over two weeks. The goal is…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can better treat severe depression in teenagers aged 13 to 17. About 220 teens will be randomly assigned to receive either esketamine or a placebo durin…

This study tests a drug called romiplostim N01 in children and young adults (ages 6-24) with cancer who have low platelets from chemotherapy. The goal is to see if weekly injections can safely raise platelet counts and reduce bleeding risk. About 50 participants will receive the …

This study tests a digital program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based tools. Researchers want to find out which parts of the program work best to improve …

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in adolescent refugees aged 14 to 18. About 80 participants will be randomly assigned to either the START NOW program or standard care. The goal is to see if t…

This study tests whether a special 3D exercise program (the Schroth method) can improve trunk muscle endurance, sleep quality, and quality of life in adolescents aged 12-18 with hyperkyphosis (excessive rounding of the upper back). Sixty participants will be assigned to the exerc…

This study looks at why Hispanic teenagers often wait longer for knee surgery after an injury, which can lead to long-term problems like arthritis. Researchers will interview athletes, families, and coaches to understand the barriers, then design a program to help them get care f…

This study listens to the experiences of adolescents with anorexia nervosa, their parents, and healthcare professionals regarding psychotropic medications. Through interviews, researchers aim to understand perceptions and feelings without any preconceived ideas. No treatment is g…

This study will follow 1,000 teenagers hospitalized for major depression or bipolar disorder. Researchers will collect data from blood tests, brain scans, wearable devices, and questionnaires to identify new risk factors and build models that predict how well a teen will respond …

This study is testing a family support program called Promoting Positive Family Futures (PPFF) for families in Palestine affected by ongoing conflict and violence. About 300 families with a teen aged 13–16 will be randomly assigned to either the program or usual services. Researc…

This study looks at how much parents should be involved when teens get brief counseling for mild alcohol problems during regular doctor visits. Researchers will compare no parent involvement, a live session with a parent, or an online program for parents. The goal is to find the …

This study collects movement data from 40 healthy children and teens aged 3-25. Participants walk, run, and do other activities while cameras and force plates record their body positions and joint movements. The goal is to create a baseline of normal movement to compare with chil…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which parts of the brain are affected. The goal is to learn more about how therapy works, which c…