ADOLESCENT

This study tests a drug called romiplostim N01 in children, adolescents, and young adults (ages 6-24) with cancer who develop low platelet counts from chemotherapy. The drug is given as a weekly shot to help the body produce more platelets. The goal is to see if it can safely and…

This study tests whether a single injection of Telpegfilgrastim works better than daily Filgrastim shots to prevent fever and low white blood cells in children and young adults (ages 6-24) with solid tumors receiving strong chemotherapy. About 132 participants will receive either…

This study tests whether dapagliflozin, a drug already used in adults to protect kidneys, can reduce protein leakage in the urine of teenagers with mild chronic kidney disease. Two hundred adolescents aged 14 to 18 will receive either the drug or a placebo for six months. The goa…

This trial tests several cancer drugs in children and young adults with solid tumors. It uses a master protocol to test different drug combinations more efficiently. About 105 participants will receive one of eight drugs, including ramucirumab, cyclophosphamide, and others. The g…

This study is testing a drug called brentuximab vedotin, combined with chemotherapy, for children, adolescents, and young adults newly diagnosed with classical Hodgkin lymphoma. The goal is to see if this approach can achieve a faster and more complete response, allowing fewer pa…

This study tests whether adding a caregiver session to a brief alcohol counseling program helps teens aged 12-17 reduce their drinking. 615 teens with mild alcohol problems will be assigned to teen-only counseling, counseling with a live caregiver session, or counseling with an o…

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or st…

This study tests whether a pectoral nerve block (PECS) given before surgery can lower pain and the need for morphine after a heart device implant in children aged 3 to 18. Half the children will get the nerve block plus standard wound numbing, while the other half get only wound …

This study is testing whether a structured breathing practice is a practical and acceptable option for teenagers aged 12 to 17 who have been diagnosed with anxiety or depression. The program, called Seokmun Hoheup, starts with 15-minute sessions and gradually increases to 36 minu…

This study tests whether a culturally adapted skills training program called START NOW can reduce depression and anxiety in teen refugees. About 80 participants aged 14-18 will be randomly assigned to either the training or standard care. The goal is to see if the program helps t…

This study tests whether a special 3D exercise program (the Schroth method) can improve back muscle endurance, sleep, and quality of life in 60 adolescents aged 12-18 with hyperkyphosis (excessive rounding of the upper back). Participants will do the exercises for at least 3 mont…

This study tests whether adding a low dose of esketamine (a fast-acting anesthetic) to standard electroconvulsive therapy (ECT) can improve depression outcomes in adolescents aged 13-17 with severe depression. About 220 participants will be randomly assigned to receive either esk…

This study tests a digital program designed to help teens and young adults who have survived cancer manage symptoms of depression. The program includes educational content and four evidence-based tools. Researchers want to find out which parts of the program work best to reduce d…

This study tests a gentle, non-invasive brain stimulation method called HD-tDCS in 100 teenagers with bipolar depression. Half get real stimulation, half get a fake version, and both continue their usual medications. Researchers will check if depression scores improve after two w…

This study looks at why teenagers aged 10 to 18 wait more than 6 hours before going to the hospital for testicular torsion, a painful emergency that can damage the testicle. Researchers will ask 150 teens who had surgery for this condition to fill out a questionnaire about their …

This study tests a group-based program called Promoting Positive Family Futures (PPFF) for families in Palestine. The program helps parents and their teenage children (ages 13-16) learn to manage emotions, resolve conflicts constructively, and build a sense of safety and support …

This study is collecting movement data from 40 healthy children and young adults aged 3 to 25. Participants will walk while cameras and force plates record their motion. The goal is to create a baseline of normal movement patterns, which can help doctors better understand and tre…

This study looks at how trauma-focused therapy changes brain connections in teenagers with PTSD. Researchers will use brain scans before and after each phase of therapy to understand which brain networks are involved. The goal is to learn how therapy works in the brain, which cou…

This study is tracking 1,000 teenagers hospitalized for depression or bipolar disorder. Researchers will collect blood samples, brain scans, wearable device data, and psychological tests to identify patterns that predict how well a teen responds to treatment. The goal is to find …

This study uses interviews to learn how adolescents with anorexia nervosa, their parents, and healthcare professionals experience psychotropic drugs. Researchers will talk to 90 participants to uncover their thoughts and feelings. The goal is to better understand the personal imp…