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TB prevention for kids: immediate treatment may stop infection before it starts

NCT ID NCT07086820

Recruiting now Prevention Sponsor: Pontificia Universidad Catolica de Chile Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or standard care (treatment only if they test positive). The goal is to see if early treatment reduces new infections measured by a blood test after 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
isoniazid and rifapentine (weekly for 12 weeks)
What this could lead to
If successful, this approach could prevent many new TB infections in children and adolescents exposed at home, reducing the spread of TB.
What could go wrong
This is a relatively small trial (647 participants) in one country, so results may not apply everywhere. The window prophylaxis may not reduce infections more than standard care, and side effects from the drugs are possible.

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Conditions

The condition(s) this trial relates to.

tuberculosis latent tuberculosis infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADOLESCENT CHILDREN HOUSEHOLD CONTACTS TUBERCULOSIS TUBERCULOSIS INFECTION TUBERCULOSIS INFECTION, LATENT

Contacts and locations

Locations

  • Complejo Asistencial Dr. Sótero Del Río

    RECRUITING

    Puente Alto, Santiago Metropolitan, Chile

  • Hospital Alto Hospicio

    NOT_YET_RECRUITING

    Alto Hospicio, Tarapacá, Chile

  • Hospital CRS El Pino

    RECRUITING

    San Bernardo, Santiago Metropolitan, Chile

  • Hospital Claudio Vicuña

    NOT_YET_RECRUITING

    San Antonio, Valparaiso, Chile

  • Hospital Clínico Félix Bulnes

    RECRUITING

    Santiago, Santiago Metropolitan, Chile

  • Hospital Clínico San Borja Arriarán

    RECRUITING

    Santiago, Santiago Metropolitan, Chile

  • Hospital Dr. Carlos Cisterna

    RECRUITING

    Calama, Antofagasta, Chile

  • Hospital Dr. Gustavo Fricke

    NOT_YET_RECRUITING

    Viña del Mar, Valparaiso, Chile

  • Hospital Luis Calvo Mackenna

    NOT_YET_RECRUITING

    Providencia, Santiago Metropolitan, Chile

  • Hospital San Juan de Dios de La Serena

    NOT_YET_RECRUITING

    La Serena, Coquimbo Region, Chile

  • Hospital San Juan de Dios de Santiago

    NOT_YET_RECRUITING

    Santiago, Santiago Metropolitan, Chile

  • Hospital de Coquimbo

    NOT_YET_RECRUITING

    Coquimbo, Coquimbo Region, Chile

  • Hospital de Niños Roberto del Río

    NOT_YET_RECRUITING

    Independencia, Santiago Metropolitan, Chile

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