TB prevention for kids: immediate treatment may stop infection before it starts
NCT ID NCT07086820
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving tuberculosis (TB) prevention drugs immediately to children and teens who live with someone with active TB can stop them from getting infected. About 647 participants aged 5 to 17 will be randomly assigned to receive either immediate treatment or standard care (treatment only if they test positive). The goal is to see if early treatment reduces new infections measured by a blood test after 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
isoniazid and rifapentine (weekly for 12 weeks)
What this could lead to
If successful, this approach could prevent many new TB infections in children and adolescents exposed at home, reducing the spread of TB.
What could go wrong
This is a relatively small trial (647 participants) in one country, so results may not apply everywhere. The window prophylaxis may not reduce infections more than standard care, and side effects from the drugs are possible.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHILDREN are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Complejo Asistencial Dr. Sótero Del Río
RECRUITINGPuente Alto, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Alto Hospicio
NOT_YET_RECRUITINGAlto Hospicio, Tarapacá, Chile
Contact Email: •••••@•••••
Contact
-
Hospital CRS El Pino
RECRUITINGSan Bernardo, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Claudio Vicuña
NOT_YET_RECRUITINGSan Antonio, Valparaiso, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Clínico Félix Bulnes
RECRUITINGSantiago, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Clínico San Borja Arriarán
RECRUITINGSantiago, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Dr. Carlos Cisterna
RECRUITINGCalama, Antofagasta, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Dr. Gustavo Fricke
NOT_YET_RECRUITINGViña del Mar, Valparaiso, Chile
Contact Email: •••••@•••••
Contact
-
Hospital Luis Calvo Mackenna
NOT_YET_RECRUITINGProvidencia, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact
-
Hospital San Juan de Dios de La Serena
NOT_YET_RECRUITINGLa Serena, Coquimbo Region, Chile
Contact Email: •••••@•••••
Contact
-
Hospital San Juan de Dios de Santiago
NOT_YET_RECRUITINGSantiago, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact
-
Hospital de Coquimbo
NOT_YET_RECRUITINGCoquimbo, Coquimbo Region, Chile
Contact Email: •••••@•••••
Contact
-
Hospital de Niños Roberto del Río
NOT_YET_RECRUITINGIndependencia, Santiago Metropolitan, Chile
Contact Email: •••••@•••••
Contact