New hope for tough prostate cancer: Immune-Engaging drug enters human trials
NCT ID NCT06990880
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new drug, GSK5458514, designed to help the immune system attack prostate cancer cells. It is for men with metastatic castration-resistant prostate cancer that has spread and stopped responding to hormone therapy. The study will first find a safe dose, then test that dose alone or with other cancer drugs in a small group of 85 participants.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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GSK Investigational Site
RECRUITINGPhoenix, Arizona, 85054, United States
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GSK Investigational Site
RECRUITINGDenver, Colorado, 80218, United States
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GSK Investigational Site
RECRUITINGNew Haven, Connecticut, 06510, United States
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GSK Investigational Site
RECRUITINGRochester, Minnesota, 55905, United States
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GSK Investigational Site
RECRUITINGEast Brunswick, New Jersey, 08816, United States
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GSK Investigational Site
RECRUITINGNashville, Tennessee, 37203, United States
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GSK Investigational Site
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGMontreal, Quebec, H4A 3J1, Canada
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GSK Investigational Site
RECRUITINGLyon, 69373, France
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GSK Investigational Site
RECRUITINGVillejuif, 94805, France
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GSK Investigational Site
RECRUITINGKanagawa, 232-0024, Japan
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GSK Investigational Site
RECRUITINGTokyo, 104-0045, Japan
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GSK Investigational Site
RECRUITINGTokyo, 135-8550, Japan
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GSK Investigational Site
RECRUITINGBadajoz, 06080, Spain
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GSK Investigational Site
RECRUITINGBarcelona, 08023, Spain
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GSK Investigational Site
RECRUITINGMadrid, 28040, Spain
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGMadrid, 28050, Spain
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GSK Investigational Site
RECRUITINGMálaga, 29010, Spain
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGPozuelo de AlarcOn Madr, 28223, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a blast of testosterone shrink hard-to-treat prostate cancer?
- Can a Two-Drug attack stall resistant prostate cancer?
- A PET scan and a blood test may predict which men with advanced prostate cancer will benefit from targeted therapy
- Can a new daily pill slow advanced prostate cancer?
- Radiation plus hormone therapy may slow resistant prostate cancer
- Targeted radiation zaps prostate cancer cells in new trial