New hope for myeloma patients: drug combo trial launches

NCT ID NCT06679101

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether a new combination of drugs—belantamab mafodotin, lenalidomide, and dexamethasone—can help people with newly diagnosed multiple myeloma who cannot have a stem cell transplant. The study will compare this new combo to the current standard treatment (daratumumab, lenalidomide, and dexamethasone) in 520 participants. The goal is to see if the new combo delays cancer progression or leads to deeper remission.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belantamab mafodotin, lenalidomide, and dexamethasone
What this could lead to: If successful, this combination could offer a new, more effective first-line treatment option for people with newly diagnosed multiple myeloma who cannot have a stem cell transplant.
What could go wrong: This is an early-stage Phase 3 trial, so results are not guaranteed. The new combination may not be better than the current standard, and side effects like eye problems or low blood counts are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA NEWLY DIAGNOSED MULTIPLE MYELOMA

Contacts and locations

Locations

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Mobile, Alabama, 36607, United States
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Phoenix, Arizona, 85054, United States
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Beverly Hills, California, 90211, United States
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Pasadena, California, 91105, United States
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Aurora, Colorado, 80012, United States
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Washington D.C., District of Columbia, 20007, United States
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Englewood, Florida, 34223, United States
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Lady Lake, Florida, 32159, United States
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Pembroke Pines, Florida, 33024, United States
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Saint Augustine, Florida, 32256, United States
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Atlanta, Georgia, 30322, United States
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Portland, Maine, 04074, United States
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Worcester, Massachusetts, 01655, United States
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Ann Arbor, Michigan, 48103, United States
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Detroit, Michigan, 48201, United States
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Billings, Montana, 59102, United States
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Hackensack, New Jersey, 07601, United States
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New York, New York, 10065, United States
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Stony Brook, New York, 11790, United States
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Charlotte, North Carolina, 28204, United States
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Winston-Salem, North Carolina, 27103, United States
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Columbus, Ohio, 43214, United States
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Providence, Rhode Island, 02903, United States
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Austin, Texas, 78705, United States
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Austin, Texas, 78712, United States
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Kingwood, Texas, 77339, United States
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San Antonio, Texas, 78240, United States
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Tyler, Texas, 75702, United States
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Fairfax, Virginia, 22031, United States
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Puyallup, Washington, 98373, United States
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Capital Federal, C1426ANZ, Argentina
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Ciudad Autonoma de Buenos Aire, 1414, Argentina
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Córdoba, Argentina
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Rosario, S2002, Argentina
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Viedma, R8500ACE, Argentina
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Gosford NSW, New South Wales, 2250, Australia
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Box Hill, Victoria, 3128, Australia
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Melbourne, Victoria, 3004, Australia
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Fitzroy, Australia
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Herston, Australia
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St Leonards, Australia
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Bruges, 8000, Belgium
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Brussels, 1200, Belgium
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Ghent, 9000, Belgium
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Hornu, 7301, Belgium
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Roeselare, 8800, Belgium
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Salvador, Estado de Bahia, Brazil
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Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Barretos, 14784-400, Brazil
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Joinville, 89201-260, Brazil
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Porto Alegre, Brazil
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São Paulo, 01509-010, Brazil
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São Paulo, 04537-080, Brazil
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São Paulo, 05403-000, Brazil
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São Paulo, Brazil
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Teresina, 64049-200, Brazil
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Vitória, 29043-260, Brazil
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Saint John, New Brunswick, E2L 4L2, Canada
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Beijing, 100191, China
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Chengdu, 610072, China
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Chongqing, 400016, China
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Guangzhou, 510060, China
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Guangzhou, 510515, China
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Hangzhou, 310003, China
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Nanchang, 330000, China
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Nanchang, China
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Nanjing, 210008, China
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Shanghai, 200032, China
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Shanghia, 200080, China
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Shenzhen, 430022, China
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Shenzhen, 518039, China
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Tianjin, 300020, China
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Wenzhou, 325000, China
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Xi'an, 710004, China
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Ostrava, 708 52, Czechia
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Prague, 100 34, Czechia
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Bobigny, 93009, France
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Nantes, 44202, France
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Villejuif, 94805, France
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Jena, Europe, 7747, Germany
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Lübeck, Schleswig-Holstein, 23538, Germany
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Chemnitz, 9116, Germany
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Cologne, 50937, Germany
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Dresden, 01307, Germany
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Hamburg, 20246, Germany
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Hanover, 30625, Germany
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Mainz, 55131, Germany
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Würzburg, 97080, Germany
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Alexandroupoli, 68 100, Greece
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Athens, 106 76, Greece
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Athens, 115 28, Greece
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Athens, Greece
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Pátrai, 26504, Greece
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Thessaloniki, 54007, Greece
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Ahmedabad, 380009, India
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Bangalore, 560054, India
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Hyderabad, 500033, India
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Kolkata, 700014, India
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Kolkata, 700156, India
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Pune, 411001, India
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Sushrut Hospital and Research, 400071, India
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Dublin, D09V2N0, Ireland
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Galway, Ireland
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Waterford, Ireland
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Beersheba, 84101, Israel
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Jerusalem, 91120, Israel
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Koranit, 2018100, Israel
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Petah Tikva, 49100, Israel
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Tel Aviv, 64239, Israel
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Ancona, Italy
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Catania, Italy
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Meldola FC, 47014, Italy
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Palermo, 90127, Italy
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Pavia, 27100, Italy
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Pisa, Italy
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Roma, 00161, Italy
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Shibuya-Ku, Tokyo, 150-8935, Japan
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Aichi, 467-8602, Japan
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Ehime, 790-0024, Japan
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Ehime, 790-8524, Japan
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Fukuoka, 815-8555, Japan
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Fukushima, 960-1295, Japan
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Gunma, 371-8511, Japan
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Hyōgo, 660-8550, Japan
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Hyōgo, 670-8540, Japan
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Ibaraki, 300-0028, Japan
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Ishikawa, 920-8641, Japan
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Kanagawa, 211-8510, Japan
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Miyagi, 983-8520, Japan
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Nara, 632-8552, Japan
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Numakunai, 028-3695, Japan
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Osaka, 589-8511, Japan
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Sapporo, 003-0006, Japan
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Suita, 565-0871, Japan
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Tokyo, 105-8471, Japan
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Yamagata, 990-9585, Japan
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Bergen, 5021, Norway
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Lrenskog, 1470, Norway
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Oslo, Norway
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Lodz, 93-513, Poland
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Lublin, 20-954, Poland
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Lublin, Poland
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Warsaw, 02-781, Poland
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Wałbrzych, 58-309, Poland
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Kuils River, 7580, South Africa
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Pretoria, 0181, South Africa
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Hwasun, 519-763, South Korea
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Jeonju, 561-712, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Seoul, 138-736, South Korea
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Ulsan, 44033, South Korea
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Badalona, Spain
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Barcelona, 08035, Spain
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Gijón, 33394, Spain
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Madrid, 28007, Spain
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Madrid, 28041, Spain
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Madrid, Spain
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Málaga, 29010, Spain
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Murcia, 30120, Spain
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Salamanca, Spain
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Santander, 39011, Spain
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Valladolid, 47003, Spain
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Kaohsiung City, 807, Taiwan
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Taichung, 407219, Taiwan
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Tainan, 704, Taiwan
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Taipei, 10002, Taiwan
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Taoyuan, 33305, Taiwan
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Samsun, Atakum, 55200, Turkey (Türkiye)
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Kocaeli, İzmit, 41001, Turkey (Türkiye)
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Ankara, Yenimahalle, 06170, Turkey (Türkiye)
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Adana, 01330, Turkey (Türkiye)
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Ankara, 06680, Turkey (Türkiye)
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Sisli - Istanbul, 34381, Turkey (Türkiye)
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Leicester, LE1 5WW, United Kingdom
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Middlesbrough, TS4 3BW, United Kingdom
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Oxford, OX3 7LE, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom

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