Glaxosmithkline

This study tested whether a 2-dose schedule of an experimental Shigella vaccine is safe and triggers a protective immune response in African infants. The trial involved 200 healthy 9-month-old babies in Kenya. Researchers measured antibody levels and monitored for side effects to…

This study tested the safety and immune response of a new vaccine (Bexsero) designed to protect infants from a serious type of bacterial meningitis (Meningococcal Group B). Over 1,100 healthy babies, aged 6 to 12 weeks, received the new vaccine along with their standard infant im…

This study tested an investigational RSV vaccine in adults aged 18-49 who have chronic health conditions that put them at higher risk for severe RSV illness. Researchers compared the vaccine's safety and the immune response it triggered in these younger adults to the response in …

This study was the first time a new combination vaccine was tested in people. It aims to prevent two serious types of Salmonella infection: invasive nontyphoidal Salmonella (iNTS) and typhoid fever. Researchers gave the vaccine to 155 healthy adults in Europe and Africa to check …

This study tested a new type of flu shot made with mRNA technology, similar to some COVID-19 vaccines. It involved 845 healthy adults to see how well their immune systems responded to different doses and to check for side effects. The goal was to gather data to help develop a bet…

This was the first human study of a new mRNA-based flu vaccine candidate from GSK. It tested the safety and immune response of different doses in 324 healthy younger and older adults. The main goal was to see how well the body reacted to the vaccine and to identify any side effec…

This was the first study in people to test a new vaccine designed to prevent diarrhea caused by Shigella bacteria. Researchers tested three different doses of the vaccine, starting with healthy adults in Europe and then moving to adults, children, and finally infants in Africa, w…

This study tested a new vaccine called AFX3772, designed to protect healthy infants from serious pneumococcal infections like pneumonia. Researchers compared three different versions of the new vaccine to two existing, approved vaccines (Prevnar 13 and Prevnar 20) to see which wa…

This study tested a single-dose RSV vaccine in adults aged 60 and older. It aimed to see if the vaccine triggered a strong immune response in participants from China that was similar to the response seen in older adults from other countries in a previous successful trial. Researc…

This study tested a new mRNA-based vaccine designed to protect against a potential pandemic strain of bird flu (H5 influenza). Nearly 1,000 healthy adults aged 18 to 85 received different doses of the vaccine to find the safest and most effective amount. The main goals were to ch…

This study tested a new single vaccine designed to protect against both seasonal flu and COVID-19. It involved 106 healthy adults to check for side effects and see if it safely triggers an immune response. This was the first time this specific combination vaccine was tested in pe…

This study tested whether two important childhood vaccines—one for polio and one for rotavirus (a common cause of severe diarrhea)—are safe and work well when given at the same time to healthy infants. It involved 400 Chinese babies aged 6 to 10 weeks. Researchers measured the ba…

This early-stage study tested the safety and immune response of a new ingredient (called AS37) added to a Hepatitis B vaccine. The trial involved 122 healthy adults aged 18-45 who had never been vaccinated against Hepatitis B. Researchers gave participants two shots one month apa…

This study tested new COVID-19 booster vaccines in healthy adults who were already vaccinated. Researchers compared the safety and immune response of these new vaccines against a standard control vaccine. They also tested how different storage conditions might affect one of the v…

This study tested a new vaccine designed to protect older adults from severe Respiratory Syncytial Virus (RSV) lung infections. It involved 751 Indian participants aged 50 and older, including those with underlying health conditions like heart or lung disease. Researchers gave a …

This study tested a new vaccine designed to prevent cytomegalovirus (CMV) infections in healthy adults aged 18-50. Researchers gave 339 participants different dose levels of the vaccine to check for safety and see if it triggered an immune response. The main goal was to monitor s…

This study monitored the long-term safety and effectiveness of NUCALA injections for people with EGPA, a rare autoimmune disease. It followed over 4,000 patients for up to two years while they received the drug in real-world settings. The goal was to collect information on side e…

This study tested an investigational long-acting injection called depemokimab for adults with chronic sinusitis and troublesome nasal polyps. The goal was to see if regular injections over one year could safely reduce polyp size, improve nasal blockage, and lessen symptoms like l…

This study tested a two-step treatment for adults with chronic Hepatitis B who were already on standard antiviral pills. First, participants received an investigational injection (an ASO) for 12 or 24 weeks to try to lower the virus. Then, they received an investigational immunot…

This study tested a new tuberculosis drug, GSK3036656, in different two-drug combinations for 14 days. It involved 127 adults with newly diagnosed, drug-sensitive lung TB. The main goal was to see how quickly these combinations could kill the TB bacteria in sputum and to check th…

This early-stage study tested a new oral drug, GSK3882347, for treating uncomplicated urinary tract infections (UTIs) in adult women. It compared the new drug's safety and ability to clear the infection to a standard antibiotic, nitrofurantoin. The main goal was to see if the new…

This study tested whether a drug called mepolizumab, given as a shot under the skin, could help control a rare blood disorder called Hypereosinophilic Syndrome (HES) in children and teenagers aged 6 to 17. The main goal was to see if it could reduce the number of disease flare-up…

This study tested a drug called daprodustat to treat anemia (low red blood cells) in children and teenagers with chronic kidney disease. The main goals were to see how safe the drug was and if it could effectively raise hemoglobin levels over a year. It included a very small grou…

This study looked at how well a 3-in-1 inhaler called Trelegy works for people with symptomatic COPD in their daily lives. Over 460 adults with COPD used the inhaler for 12 weeks. Researchers measured changes in their breathing, shortness of breath, and overall health status to s…

This Phase 3 study tested an injectable drug called depemokimab in 264 adults with chronic sinusitis and troublesome nasal polyps. The goal was to see if the drug could safely reduce polyp size and improve symptoms like nasal blockage and loss of smell over 52 weeks. Participants…

This study tested whether adding the drug belimumab to standard lupus treatment helps children aged 5-17 with active disease. Researchers compared monthly belimumab infusions against placebo infusions in 93 participants over one year, while all continued their regular medications…

This study aimed to monitor the long-term safety and effectiveness of Benlysta injections for treating Systemic Lupus Erythematosus (SLE) in real-world medical practice. It followed over 1,500 patients for one year after they started treatment. The goal was to gather information …

This study tested an experimental drug called belantamab mafodotin in people with advanced multiple myeloma, a blood cancer, who had already tried and stopped responding to at least three other types of treatment. The main goal was to see if the drug could shrink the cancer and f…

This study tested a new immunotherapy designed to help the body's immune system fight the herpes virus. It involved 505 healthy adults and adults with recurrent genital herpes to check for safety and see if the treatment could reduce outbreaks and viral shedding. The goal is to b…

This study tested a version of the lupus drug belimumab given as an injection under the skin in Chinese children. It involved 16 children aged 5-17 who had already been receiving the drug by IV. The main goal was to measure how the drug behaved in the body at different weights an…

This study tested whether a new propellant (HFA-152a) in asthma rescue inhalers is as safe as the current standard propellant (HFA-134a). 477 adults with stable asthma used inhalers containing one of the two propellants for an extended period. Researchers monitored participants f…

This study tested an oral antibiotic called gepotidacin to see how quickly it could improve symptoms and how safe it was for women with uncomplicated bladder infections (acute cystitis). The trial involved 97 female participants aged 12 and older who had recent UTI symptoms. Rese…

This study followed 641 adults and adolescents with severe asthma for one year to check the long-term safety of an injected medication called depemokimab. Participants had already taken the drug in earlier trials. The main goal was to monitor for side effects and see if the drug …

This large, completed Phase 3 study tested if switching to a new, long-acting injection called GSK3511294 (depemokimab) was as good as staying on current treatments (mepolizumab or benralizumab) for controlling severe asthma flare-ups. It involved over 1,700 teens and adults with…

This early-stage study tested a single dose of an experimental drug, GSK4532990, in 61 adults with non-alcoholic steatohepatitis (NASH), a type of fatty liver disease. The main goals were to see how the body processes the drug, how it affects the liver, and to check its safety. R…

This study tested whether a new shingles vaccine could prevent a second, painful outbreak in adults aged 50 and older who had already had shingles. Over 1,400 participants received either the two-dose vaccine or a placebo shot to compare the rates of new shingles cases. Researche…

This study tested whether a new RSV vaccine and a COVID-19 booster shot could be given safely at the same time to adults aged 50 and older. Researchers compared the immune response and side effects when the shots were given together versus separately. The goal was to see if getti…

This study followed over 7,500 older adults for up to 12 years to see how long the Shingrix shingles vaccine remained effective and safe. It was a long-term check-up on two earlier major trials, and also tested whether giving one or two extra booster doses could further strengthe…

This large study monitored the safety and real-world performance of the RTS,S malaria vaccine after it was introduced into routine childhood immunization programs in sub-Saharan Africa. Researchers followed over 77,000 young children, comparing health outcomes between those who r…

This study followed people who had received an RSV vaccine or a placebo in earlier trials to see if the vaccine affected their health or their baby's health in pregnancies that happened later. It did not give any new treatments; it only collected safety information from over 3,80…

This study followed over 3,100 adults with active lupus for five years to track the safety and effectiveness of the drug Benlysta (belimumab) compared to standard treatments. Participants were either taking Benlysta or other standard lupus medications, and doctors could change tr…

This study aimed to gather real-world information about adults with lupus nephritis, a serious kidney complication of lupus, in five Gulf countries. Researchers followed 193 participants for a year to document their symptoms, the treatments they received, their quality of life, a…

This early-stage study aimed to understand how the body absorbs a common asthma relief drug (salbutamol) when it's delivered from an inhaler using a new, potentially more environmentally friendly propellant gas. Researchers compared this new propellant to the one currently used i…