Glaxosmithkline

This early-stage trial is testing several doses of an experimental mRNA vaccine against RSV in 213 healthy adults aged 18-45. The goal is to check the vaccine's safety and how well it triggers an immune response. Participants receive two shots, and researchers monitor for side ef…

This early-stage trial tests a new vaccine against cytomegalovirus (CMV), a common virus that can cause serious problems in newborns and people with weakened immune systems. The study involves 339 healthy adults aged 18 to 50, who will receive different doses of the vaccine or a …

This study tested a new combination vaccine designed to protect healthy infants against five types of meningococcal bacteria (A, B, C, W, and Y) that can cause serious infections like meningitis. Over 700 infants received different doses or combinations of the vaccine to check sa…

This phase 3 study tested a single dose of an investigational RSV vaccine in 751 adults aged 60 and older, and those 50-59 at increased risk for severe RSV. The goal was to see how well the vaccine boosts the immune system and whether it is safe. Participants received either the …

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This study tested an experimental gonorrhea vaccine in healthy adults aged 18 to 50. The goal was to see if the vaccine is safe and can prevent gonorrhea infections. Over 1,000 participants received either the vaccine or a placebo (salt water shot) and were monitored for side eff…

This study tested an experimental RSV vaccine in adults who had a lung or kidney transplant, as well as in healthy adults over 50. The goal was to see if the vaccine could safely boost their immune response against RSV, a common and potentially serious respiratory virus. Research…

This study tested a new vaccine called Pn-MAPS30plus to see if it is safe and helps the body fight pneumonia-causing bacteria. It involved 127 healthy adults aged 50 to 64. The vaccine is designed to protect against more types of the bacteria than current vaccines.

This study tested new mRNA-based seasonal flu vaccines in 776 healthy adults aged 18 and older. The goal was to see how safe the vaccines are and how well they boost the immune system. Researchers measured side effects and immune responses to find the best vaccine candidate.

This study tested an experimental RSV vaccine in adults aged 60 and older in China. The goal was to see if the vaccine produces a strong immune response similar to that seen in older adults from other countries, where the vaccine already proved effective. About 2,620 participants…

This study looked at whether a booster dose of the meningitis B vaccine (Bexsero) works well and is safe for healthy people aged 10 to 20. It included 312 participants who either got the vaccine as babies or had never received it. The goal was to see if the booster triggers a str…

This early-stage trial tested an experimental mRNA-based flu vaccine in 324 healthy younger (18-45) and older (60-80) adults. The main goal was to check safety and how well the vaccine triggers an immune response. Participants received one of several dose levels or a placebo, and…

This study tested a new mRNA-based flu vaccine from GSK in 845 healthy adults aged 18 to 85. The goal was to find the best dose and check how well it triggers the immune system and whether it is safe. Results will help decide if larger studies should move forward.

This study tested the RTS,S/AS01E malaria vaccine in nearly 78,000 young children in Sub-Saharan Africa. Researchers checked the vaccine's safety and how well it prevents malaria. The goal was to see if the vaccine can be safely used in routine immunization programs to protect ch…

This study looked at whether giving the meningitis B vaccine (Bexsero) and the pneumonia vaccine (PCV13) along with routine baby shots is safe and works well. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever,…

This study tested a new mRNA vaccine designed to protect against a potential pandemic of H5 bird flu. Nearly 1,000 healthy adults aged 18 to 85 received different doses to find the safest and most effective one. Researchers monitored side effects like pain, fever, and fatigue, an…

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This early-stage study tested a new hepatitis B vaccine that includes an experimental booster called AS37. The goal was to see if the vaccine is safe and how well it triggers the immune system. 122 healthy adults aged 18-45 received two doses one month apart. Researchers monitore…

This completed phase 3 trial tested whether giving an RSV vaccine and a COVID-19 mRNA vaccine at the same time is as safe and effective as giving them separately. About 841 adults aged 50 and older took part. Researchers measured immune responses and side effects one month after …

This study followed over 7,500 older adults who received the shingles vaccine to see how well it prevents shingles over many years. Researchers also tested giving extra doses to some participants. The goal was to understand how long protection lasts and whether booster shots are …

This study tested a two-dose shingles vaccine (HZ/su) in 1,430 adults aged 50 and older who had already experienced shingles. The goal was to see if the vaccine could prevent the virus from coming back and to check its safety and immune response. Participants received either the …

This study tested a new vaccine designed to protect against two types of Salmonella bacteria that cause serious infections like typhoid fever and invasive nontyphoidal Salmonella disease. The trial involved 155 healthy adults in Europe and Africa who received three doses of the v…

This phase 2 study tested several new mRNA COVID-19 booster vaccines in 692 healthy adults who had already received a primary vaccine series. The goal was to compare the safety and immune response of these experimental boosters against a control vaccine. Participants received a s…

This study tested whether giving the polio vaccine (IPV) at the same time as a rotavirus vaccine (Rotarix PCV-free) is safe and works well in healthy Chinese infants aged 6-10 weeks. About 400 infants received the vaccines either together or a few weeks apart. The main goal was t…

This study tested an experimental RSV vaccine in about 1,500 adults. It compared the immune response and safety in younger adults (18-49 years) who are at increased risk for RSV disease to older adults (60 years and older). The goal was to see if the vaccine works as well in the …

This early-stage trial tested a new mRNA vaccine that combines protection against seasonal flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if a combined vac…

This study investigates the safety and how the body processes intravenous (IV) zanamivir in hospitalized infants under 6 months old with complicated influenza. Currently, no antiviral is approved for this age group, leaving them vulnerable. The trial will measure drug levels in t…

This phase 3 trial tests whether mepolizumab, an injectable drug, can reduce nasal polyp size and improve symptoms like nasal blockage in adults with chronic rhinosinusitis and nasal polyps. Participants receive either mepolizumab or a placebo every four weeks for a year. The stu…

This phase 3 trial tests whether mepolizumab, an injectable antibody that calms a type of immune cell, can reduce nasal polyp size and improve breathing when added to standard nasal spray therapy. About 400 adults with severe bilateral nasal polyps will receive either mepolizumab…

This Phase 3 study tests bepirovirsen, an experimental drug, in 857 adults with chronic hepatitis B who are already on standard antiviral therapy. The goal is to see if bepirovirsen can suppress the virus enough to allow patients to stop all hepatitis B treatments and remain viru…

This Phase 3 trial tests a drug called bepirovirsen in nearly 1,000 adults with chronic hepatitis B who are already on standard antiviral therapy. The goal is to see if bepirovirsen can suppress the virus enough that participants can safely stop all hepatitis B medications and re…

This study tested a drug called BOS-580 (efimosfermin) in 231 obese adults with or at risk for NASH, a serious fatty liver disease. Participants received either the drug or a placebo as a shot under the skin. The main goal was to check safety and side effects. The trial is now co…

This study tested the drug mepolizumab in 16 children aged 6 to 17 with hypereosinophilic syndrome (HES), a rare condition causing too many eosinophils (a type of white blood cell). The goal was to see if mepolizumab could reduce disease flares and lower the need for steroids ove…

This study tested an experimental drug called GSK3036656 in combination with other tuberculosis medications in 127 adults with newly diagnosed, drug-sensitive pulmonary TB. Participants received one of several two-drug combinations or standard care for 14 days, then switched to s…

This phase 3 trial tested whether adding niraparib (a drug that interferes with cancer cell repair) to pembrolizumab (an immunotherapy) helps keep advanced non-small cell lung cancer from progressing. The study enrolled 666 adults whose cancer had stabilized or shrunk after initi…

This early-stage study tested a single shot of depemokimab, a biologic drug for asthma, in 20 healthy Chinese adults. Researchers measured how the drug moves through the body and checked for side effects. The goal was to gather safety and dosing information for future studies in …

This study tested whether switching to a new drug called depemokimab (GSK3511294) works as well as staying on current treatments (mepolizumab or benralizumab) for people with severe asthma linked to high eosinophils. Over 1,700 adults and teens took part for 52 weeks, continuing …

This study looked at the long-term safety and effectiveness of Benlysta, a medication for systemic lupus erythematosus (SLE), in over 1,500 patients in everyday medical practice. Researchers tracked participants for 52 weeks, monitoring side effects, disease activity, and quality…

This study looked at whether adding belimumab to standard treatment is safe and effective for Chinese children aged 5 to 17 with active lupus. 67 participants received belimumab plus their usual therapy. The main goal was to check for serious side effects and see if lupus disease…

This study tested different dosing schedules of the drug belantamab mafodotin in 177 adults with multiple myeloma that had returned or stopped responding to at least three prior treatments. The goal was to see if changing the dose or how often it is given could reduce serious eye…

This study tested the drug belimumab in children aged 5 to 17 with active lupus. Participants received either belimumab or a placebo alongside their usual treatments. The goal was to see if belimumab could safely reduce lupus disease activity over 52 weeks.

This early-stage trial tested an experimental antibiotic called GSK3882347 in 140 women with uncomplicated urinary tract infections (UTIs). Participants received either the new drug, a standard antibiotic (nitrofurantoin), or a placebo for 5 days. The study measured how well the …

This study followed about 300 people with EGPA (a rare disease causing inflammation in blood vessels) who were treated with Nucala injections for up to 2 years. Researchers monitored side effects, how well the drug controlled symptoms, and how long it took for the disease to flar…

This study looked at the long-term safety of a drug called depemokimab in 641 adults and teenagers with severe asthma caused by a type of white blood cell called eosinophils. Participants had already completed earlier studies and received the drug for another 12 months. The main …

This completed phase 2 study tested a two-step treatment for chronic hepatitis B. First, participants received an antisense drug (bepirovirsen) for 12 or 24 weeks, followed by a targeted immunotherapy. The goal was to see if this sequence could safely improve virus control beyond…

This study looked at how well a single inhaler containing three medicines (Trelegy Ellipta) works for people with chronic obstructive pulmonary disease (COPD) in real-world settings. Over 12 weeks, 463 adults aged 40 and older with ongoing COPD symptoms used the inhaler. Research…

This phase 3 trial tested a biologic drug called depemokimab in 276 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as an injection under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks to see …

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study tested a drug called daprodustat in children aged 3 months to under 18 years who have anemia due to chronic kidney disease. The goal was to see how the drug moves through the body and if it is safe. Only 4 children took part, and they received the drug for up to 52 wee…

This study tested a single dose of the experimental drug GSK4532990 in 61 adults with NASH, a type of fatty liver disease. Researchers measured how the drug moves through the body and affects liver proteins, while also checking for safety. The goal is to see if the drug can help …

This Phase 3 trial tested a biologic drug called depemokimab in 264 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as a shot under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks. The goal is …

This study tested an experimental immunotherapy for herpes simplex virus (HSV) in 505 people. In the first part, healthy adults aged 18-40 received different vaccine-like formulations to check safety. In the second part, adults aged 18-60 with recurrent genital herpes got the tre…

This phase 2 trial tested a drug called belantamab mafodotin in 221 people with multiple myeloma that had not responded to at least three prior treatments. The drug is an antibody-drug conjugate that delivers a toxin directly to cancer cells. Participants received one of two dose…

This study tested a new vaccine called AFX3772 in healthy infants about 2 months old. The goal was to see if it is safe and triggers a strong immune response against pneumococcal bacteria, which can cause pneumonia and other serious infections. Researchers compared AFX3772 with e…

This phase 3 trial is testing an experimental drug called linerixibat against a placebo in about 238 adults with primary biliary cholangitis (PBC) who suffer from moderate to severe itching. The goal is to see if linerixibat can reduce itch severity and improve quality of life ov…

This study checked if a new propellant (HFA-152a) in salbutamol rescue inhalers is as safe as the current one (HFA-134a) for adults with asthma. 477 participants used the inhalers over time, and researchers tracked side effects. The goal was to ensure the new propellant is safe f…

This completed Phase 3 trial tested the antibiotic gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if symptoms like pain and urgency improved within 24 hours. Researchers measured symptom scores and safety. The …

This study investigates whether a single dose of bepirovirsen, a potential treatment for hepatitis B, affects the heart's electrical activity. Healthy adults aged 18 to 55 receive either the drug or a placebo, and their heart rhythms are monitored continuously by ECG. The goal is…

This early-stage trial is testing a new drug called GSK4024484 in 156 healthy adults to see if it is safe and how the body handles it. Researchers will also check if food affects the drug. The goal is to gather safety information before testing it in people with malaria.

This study aims to collect up to 10 years of electronic medical records and a one-time questionnaire from over 1,100 asthma and COPD patients who previously took part in the Salford Lung Study. The goal is to better understand how these lung diseases progress and how treatments w…

This study tested two different injection devices (a safety syringe and an autoinjector) to see how the body absorbs depemokimab, a potential asthma treatment. 140 healthy adults received a single dose. The goal was to compare the drug levels in the blood, not to treat asthma.

This early study tested a single dose of the experimental drug GSK3862995B in 30 healthy adults of Chinese, Japanese, and European ancestry. The goal was to see if the drug is processed similarly across these groups, so that future global COPD studies can include diverse particip…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This completed phase 1 study in 24 healthy adults compared a new inhaler propellant (HFA-152a) to a standard one (HFA-134a) to see if it affects how the lungs clear mucus. Participants inhaled each propellant for several days, and lung clearance was measured using a radioactive t…

This 5-year study tracked over 3,000 adults with active lupus to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers monitored serious infections, cancers, and other side effects. The goal was to gather real-world data to help doctors a…

This study followed over 3,800 women who had received an RSV vaccine or a placebo in a previous pregnancy to see if it was safe in later pregnancies. No new vaccine was given—researchers just tracked pregnancy outcomes and baby health up to 42 days after birth. The goal was to de…

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) in five Gulf countries. Researchers collected information on their symptoms, treatments, and quality of life, but did not test any new medicine. The goal was to better understand the diseas…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it works like the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of salbutamol via both inhalers. The goal was to measure how much drug gets into the blood and how…