Glaxosmithkline

This study looked at whether giving an RSV vaccine and a COVID-19 booster at the same time is safe and works well in adults aged 50 and up. About 841 people took part. The goal was to see if the immune response is similar to getting the vaccines separately.

This study followed over 7,500 older adults who received the shingles vaccine to see how well it prevents shingles over many years. Researchers also tested giving one or two extra vaccine doses to see if they boost protection. The vaccine was found to be effective and safe during…

This study tested a new mRNA-based vaccine designed to protect against a potential H5 influenza (bird flu) pandemic. Nearly 1,000 healthy adults aged 18 to 85 received different doses to find the safest and most effective one. Researchers monitored side effects like pain, fever, …

This study tested new COVID-19 mRNA booster vaccines in 692 healthy adults who had already received their primary vaccine series. The goal was to see how well the boosters boosted immunity and whether they were safe. Participants received either an experimental vaccine or a contr…

This study tested a shingles vaccine (HZ/su) in 1,430 adults aged 50 and older who had already had shingles. The goal was to see if the vaccine could prevent the virus from coming back. Participants received two shots two months apart and were monitored for safety and immune resp…

This study tested a new vaccine called AFX3772 in healthy 2-month-old infants to see if it can safely prevent pneumococcal disease, which causes pneumonia and other serious infections. Researchers compared three different doses of AFX3772 with two existing vaccines (Prevnar 13 an…

This study tested a new vaccine against cytomegalovirus (CMV), a common virus that can cause serious problems in newborns and people with weak immune systems. The vaccine was given to 339 healthy adults aged 18 to 50 to see if it was safe and triggered a strong immune response. R…

This study tested a new vaccine designed to protect against two serious bacterial infections: typhoid fever and invasive nontyphoidal salmonella (iNTS). The trial involved 155 healthy adults in Europe and Africa to check the vaccine's safety and how well it triggers an immune res…

This study tested the RTS,S/AS01E malaria vaccine in over 77,000 young children across sub-Saharan Africa. Researchers checked the vaccine's safety and how well it prevents malaria as part of routine childhood shots. The goal is to protect children from this serious disease.

This study tested an experimental RSV vaccine in 386 adults, including lung and kidney transplant recipients and healthy older adults. The goal was to see if the vaccine triggers a strong immune response and is safe for people with weakened immune systems. Researchers compared on…

This study tested a new mRNA vaccine that combines protection against seasonal flu and COVID-19 in a single shot. It involved 106 healthy adults aged 18-64 to check for side effects and immune response. The flu and COVID-19 parts had been tested separately before, and this was th…

This early-stage study tested a new mRNA-based flu vaccine from GSK in 324 healthy younger (18-45) and older (60-80) adults. The main goal was to see if the vaccine is safe and triggers an immune response. Researchers monitored side effects like pain, fever, and fatigue, and meas…

This study tested an experimental RSV vaccine in adults aged 18-49 who are at increased risk for RSV disease, comparing their immune response and safety to adults aged 60 and older. Around 1,459 participants took part. The goal was to see if the vaccine works as well in younger h…

This study tested a single shot of an experimental RSV vaccine in 751 older adults (60+) and at-risk adults (50-59) in India. The goal was to see if the vaccine boosts the body's defenses against RSV, a virus that can cause serious lung infections. Researchers measured immune res…

This early-stage study tested a new hepatitis B vaccine that includes an extra ingredient called AS37 to boost the immune system. It involved 122 healthy adults aged 18-45 who received two doses one month apart. The main goal was to check safety and how well the body responds to …

This study tested an experimental RSV vaccine in over 2,600 adults aged 60 and older, including participants in China and overseas. The goal was to see if the vaccine produces a strong immune response and is safe. Researchers also tracked whether vaccinated participants got sick …

This study tested a new mRNA-based seasonal flu vaccine from GSK in 845 healthy adults aged 18 to 85. The goal was to find the best dose and check how well it triggers the immune system and how safe it is. Results will help decide if the vaccine should move into larger trials.

This study tested a new vaccine designed to protect against Shigella bacteria, a major cause of diarrhoea in children. Researchers gave the vaccine to 551 healthy people in Europe and Africa, including adults, children, and infants. The goal was to check safety and see how well t…

This study looked at how well a booster dose of the meningitis B vaccine (Bexsero) works in healthy people aged 10 to 20 who got the vaccine as babies. Researchers compared their immune response to that of people who never had the vaccine. The goal was to see if the booster provi…

This study looked at whether a meningitis B vaccine (Bexsero) is safe and works well when given alongside a pneumonia vaccine and other routine baby shots. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever, an…

This study looked at how well the Trelegy Ellipta inhaler works for people with chronic obstructive pulmonary disease (COPD) in real-world settings. Over 12 weeks, 463 adults with COPD used the inhaler, which combines three medicines to help breathing. Researchers measured change…

This study tested a drug called mepolizumab in 16 children aged 6 to 17 with hypereosinophilic syndrome (HES), a rare condition where too many white blood cells cause damage. The goal was to see if the drug could reduce disease flares and the need for steroids. Over 52 weeks, mos…

This study looked at whether adding belimumab to standard treatment is safe and works for Chinese children (ages 5-17) with active lupus. Over 52 weeks, researchers tracked side effects and disease activity using a standard lupus score. The goal was to see if the drug combination…

This study tested a new two-step treatment for adults with chronic hepatitis B who are already on standard antiviral medication. The treatment involves first giving an experimental drug (ASO) for 12 or 24 weeks, followed by a targeted immunotherapy. The goal was to see if this ap…

This study tested different doses and schedules of the drug belantamab mafodotin in 177 adults with multiple myeloma that had returned or not responded to at least three prior treatments. The goal was to see if changing the dose could reduce serious eye problems while still contr…

This study tested whether adding niraparib to the immunotherapy pembrolizumab helps keep advanced non-small cell lung cancer from growing after initial treatment. About 666 adults with stage IIIB/IV lung cancer whose disease had stabilized or shrunk after first-line chemo-immunot…

This study followed over 3,100 adults with active lupus for up to 5 years to compare the safety and effectiveness of Benlysta (belimumab) plus standard care versus standard care alone. Researchers tracked serious infections, cancers, psychiatric events, and deaths. The goal was t…

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study tested new combinations of TB drugs to see how quickly they kill TB bacteria in the lungs. 127 adults with drug-sensitive TB took one of several experimental two-drug combos or standard care for 14 days. After that, everyone switched to standard TB treatment. The goal …

This study looked at the long-term safety and effectiveness of the drug NUCALA in people with a rare disease called EGPA, which causes inflammation in small blood vessels. About 300 adults who were already prescribed NUCALA for EGPA were followed for up to 2 years. Researchers tr…

This study tested a monthly injection called depemokimab in 276 adults with chronic sinusitis and nasal polyps. The goal was to see if it could shrink polyps and ease nasal blockage over 52 weeks. Results showed improvement in polyp size and nasal obstruction scores compared to p…

This study tested an experimental immunotherapy for herpes simplex virus (HSV) in 505 people. Part 1 looked at safety in healthy adults aged 18-40, and Part 2 tested two formulations in adults aged 18-60 with recurrent genital herpes. The goal was to see if the treatment could re…

This study tested a new medicine called depemokimab for people with chronic sinusitis and nasal polyps (growths in the nose). 264 adults received injections to see if it could shrink polyps and ease stuffy noses. The goal is to control the disease, not cure it.

This study tested a drug called daprodustat in children aged 3 months to 18 years who have anemia (low red blood cells) due to chronic kidney disease. The goal was to check how the drug works in the body, its safety, and its effect on hemoglobin levels over 52 weeks. Four childre…

This study tested an experimental drug called belantamab mafodotin in 221 adults with multiple myeloma that had returned or stopped responding to at least three prior treatments. Participants received one of two doses of the drug by IV infusion. The main goal was to see how many …

This study tested a drug called belimumab in children aged 5 to 17 with active lupus. The goal was to see if adding belimumab to their usual treatment could better control the disease. The trial measured how many kids had less lupus activity after one year. Belimumab is not a cur…

This study looked at how safe and effective Benlysta is for people with lupus when used in everyday medical practice. Over 1,500 patients were followed for one year after starting the drug. Researchers tracked disease activity, quality of life, and any side effects to ensure the …

This study tested a single dose of the experimental drug GSK4532990 in 61 adults with NASH, a serious form of fatty liver disease. Researchers wanted to see how the drug moves through the body, how it affects liver proteins, and whether it is safe. The study is complete, and resu…

This study tested whether switching adults and teens (12+) with severe eosinophilic asthma from current biologic treatments (mepolizumab or benralizumab) to a new drug called depemokimab (GSK3511294) is as good at preventing asthma attacks. Over 1,700 participants were followed f…

This study looked at the long-term safety of a drug called depemokimab in 641 adults and teenagers with severe asthma that involves high levels of certain white blood cells (eosinophils). Participants who had already completed earlier studies received the drug for 12 months. The …

This study tested a new oral drug, GSK3882347, for treating uncomplicated urinary tract infections (UTIs) in women. It compared the new drug's safety and ability to clear the infection against a standard antibiotic, nitrofurantoin. The goal was to see if the new drug is safe and …

This study tested whether giving the inactivated polio vaccine (IPV) at the same time as a rotavirus vaccine is safe and produces a strong immune response. It involved 400 healthy Chinese infants aged 6 to 10 weeks. The goal is to prevent polio and severe diarrhea caused by rotav…

This study tested a new vaccine called altSonflex1-2-3 to see if it can protect African infants from shigellosis, a severe type of diarrhea. About 200 healthy infants received either the vaccine or a control, and researchers measured their immune response and any side effects. Th…

This study tested an oral antibiotic called gepotidacin in 97 female participants aged 12 and older with uncomplicated urinary tract infections. The goal was to see if symptoms like pain and urgency improved within 24 hours. Results showed that most participants felt better quick…

This study looked at the long-term safety of a new propellant (HFA-152a) used in salbutamol rescue inhalers for adults with asthma. It compared the new propellant to the current standard (HFA-134a) in 477 participants. The main goal was to see if the new propellant caused any sid…

This study tested whether a new inhaler propellant (HFA-152a) affects the lungs' ability to clear mucus compared to a standard propellant (HFA-134a). Twenty-four healthy adults inhaled each propellant for a week, and researchers measured mucus clearance using a radioactive tracer…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it delivers the drug similarly to the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of 200 or 800 micrograms in a crossover design. The goal was to compare how mu…

This follow-up study looked at the safety of a maternal RSV vaccine in women who had received it during earlier clinical trials. About 3,855 participants were monitored during any subsequent pregnancy within two years after vaccination. No new vaccine or treatment was given; the …

This study looked at 193 adults with lupus nephritis (kidney inflammation from lupus) across five Gulf countries. Researchers collected information on patients' symptoms, treatments, and quality of life using surveys and medical records. The goal was to better understand the dise…