New vaccine aims to stop deadly salmonella strains
NCT ID NCT05480800
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new vaccine designed to protect against two types of Salmonella bacteria that cause serious infections like typhoid fever and invasive nontyphoidal Salmonella disease. The trial involved 155 healthy adults in Europe and Africa who received three doses of the vaccine or a placebo. Researchers checked for side effects and measured the immune response to see if the vaccine is safe and prompts the body to fight the bacteria.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Invasive nontyphoidal Salmonella-typhoid conjugate vaccine (iNTS-TCV) and invasive nontyphoidal Salmonella-generalized modules for membrane antigens vaccine (iNTS-GMMA)
What this could lead to
If successful, this vaccine could help prevent serious Salmonella infections that cause fever and bloodstream infections, especially in Africa where they are a major health problem.
What could go wrong
This is an early phase 1/2a trial with only 155 participants, so results may not apply to larger populations. The vaccine may not provide strong enough protection or could have side effects not yet seen.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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GSK Investigational Site
Edegem, 2650, Belgium
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GSK Investigational Site
Blantyre, Malawi