One shot for two viruses: combo Flu-COVID vaccine enters human testing

NCT ID NCT06680375

Completed ⭐️ VACCINE ⭐️ Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This early-stage trial tested a new mRNA vaccine that combines protection against seasonal flu and COVID-19 in a single shot. Researchers gave the vaccine to 106 healthy adults aged 18-64 to check for side effects and measure immune responses. The goal is to see if a combined vaccine is safe and effective enough to simplify annual vaccinations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combination mRNA vaccine targeting multiple flu strains and the SARS-CoV-2 spike protein
What this could lead to: If successful, this could lead to a single annual shot that protects against both flu and COVID-19, simplifying vaccination schedules.
What could go wrong: This is an early phase 1/2 trial with only 106 participants, so results may not apply to larger populations. The combination may cause more side effects or weaker immune responses than separate vaccines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID-19

Contacts and locations

Locations

GSK Investigational Site

Anniston, Alabama, 36207, United States
GSK Investigational Site

Rolling Hills Estates, California, 90274, United States
GSK Investigational Site

Hialeah, Florida, 33012, United States
GSK Investigational Site

Miami, Florida, 33147, United States
GSK Investigational Site

Miami, Florida, 33186, United States
GSK Investigational Site

Lenexa, Kansas, 66219, United States
GSK Investigational Site

St Louis, Missouri, 63141, United States
GSK Investigational Site

Omaha, Nebraska, 68134, United States
GSK Investigational Site

Rochester, New York, 14609, United States

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