New vaccine AFX3772 aims to shield infants from pneumonia

NCT ID NCT05412030

Completed Prevention Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new vaccine called AFX3772 in healthy infants about 2 months old. The goal was to see if it is safe and triggers a strong immune response against pneumococcal bacteria, which can cause pneumonia and other serious infections. Researchers compared AFX3772 with existing vaccines (Prevnar 13 and Prevnar 20) to find the best dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AFX3772 (a pneumococcal vaccine)

What this could lead to

If successful, this could lead to a new vaccine option to protect infants against pneumococcal diseases like pneumonia.

What could go wrong

This is an early Phase 2 trial with only 388 infants, so results may not confirm effectiveness or safety in larger populations. Different vaccine formulations are being tested, and some may not work as well as existing vaccines.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

bacterial pneumonia Infections pneumonia streptococcal infection streptococcal pneumonia pneumococcal infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMOCOCCAL INFECTIONS PNEUMONIA - BACTERIAL PNEUMONIA, PNEUMOCOCCAL

Contacts and locations

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Locations

GSK Investigational Site

Miami, Florida, 33184, United States
GSK Investigational Site

Pensacola, Florida, 32503, United States
GSK Investigational Site

Saint Augustine, Florida, 32086, United States
GSK Investigational Site

Tampa, Florida, 33613, United States
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Nampa, Idaho, 83702, United States
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Bardstown, Kentucky, 40004, United States
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Lexington, Kentucky, 40517, United States
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Louisville, Kentucky, 40291, United States
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Covington, Louisiana, 70433, United States
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Haughton, Louisiana, 71037, United States
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Lafayette, Louisiana, 70508, United States
GSK Investigational Site

New Orleans, Louisiana, 70119, United States
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Mankato, Minnesota, 56001, United States
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Missoula, Montana, 59804, United States
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Hastings, Nebraska, 68901, United States
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Cincinnati, Ohio, 45245, United States
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Tulsa, Oklahoma, 74104, United States
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Cranberry Township, Pennsylvania, 16006, United States
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Jefferson Hills, Pennsylvania, 15025, United States
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N. Huntingdon, Pennsylvania, 15642, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Pittsburgh, Pennsylvania, 15217, United States
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Pittsburgh, Pennsylvania, 15234, United States
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Charleston, South Carolina, 29407, United States
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Greenville, South Carolina, 29607, United States
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Spartanburg, South Carolina, 29301, United States
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Brownsville, Texas, 78520, United States
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Dallas, Texas, 75230, United States
GSK Investigational Site

Dickinson, Texas, 77539, United States
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Houston, Texas, 77065, United States
GSK Investigational Site

Houston, Texas, 77077, United States
GSK Investigational Site

Houston, Texas, 77087, United States
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McAllen, Texas, 78504, United States
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Richmond, Texas, 77469, United States
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Layton, Utah, 84041, United States
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Roy, Utah, 84067, United States
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Salt Lake City, Utah, 84107, United States
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South Jordan, Utah, 84095, United States
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Syracuse, Utah, 84075, United States
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Norfolk, Virginia, 68701, United States
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Bayamón, 960, Puerto Rico
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Caguas, 00725, Puerto Rico
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Ponce, 00716, Puerto Rico
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San Juan, 00935-6528, Puerto Rico
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Jonesboro, Arkansas, 72401, United States
GSK Investigational Site

Los Angeles, California, 90057, United States