New shot shows promise for fatty liver disease in early trial

NCT ID NCT04880031

Completed Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tested a drug called BOS-580 (efimosfermin) in 231 obese adults with or at risk for NASH, a serious fatty liver disease. Participants received either the drug or a placebo as a shot under the skin. The main goal was to check safety and side effects. The trial is now complete, and results will help decide if further testing is warranted.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Efimosfermin (also called BOS-580), a drug given as a shot under the skin
What this could lead to: If successful, this could point toward a new treatment option for NASH, a liver disease with no approved therapies.
What could go wrong: This is an early Phase 2a trial focused on safety, not proof of effectiveness. The results may not lead to a working treatment, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NONALCOHOLIC STEATOHEPATITIS (NASH)

Contacts and locations

Locations

Accelemed Research

Austin, Texas, 78745, United States
Admed Research

Miami, Florida, 33173, United States
Advanced Clinical Research

Miami, Florida, 33156, United States
Alliance Research Institute

Canoga Park, California, 91304, United States
American Research Corporation at Texas Liver Institute

San Antonio, Texas, 78215, United States
Apex Mobile Clinical Research

Bellaire, Texas, 77401, United States
Arizona Liver Health

Chandler, Arizona, 85224, United States
Arizona Liver Health

Peoria, Arizona, 85381, United States
Arizona Liver Health

Tucson, Arizona, 85712, United States
Ark Clinical Research

Fountain Valley, California, 92708, United States
Catalina Research Institute

Montclair, California, 91763, United States
Central Research Associates

Birmingham, Alabama, 35205, United States
Century Research

Miami, Florida, 33173, United States
Charter Research

Orlando, Florida, 32803, United States
Coastal Research Institute, LLC

Fayetteville, North Carolina, 28304, United States
Covenant Metabolic Specialists - Fort Myers

Fort Myers, Florida, 33912, United States
Covenant Metabolic Specialists - Sarasota

Sarasota, Florida, 34240, United States
Entrust Clinical Research Center

Kendall, Florida, 33176, United States
Evolution Clinical Trials

Hialeah Gardens, Florida, 33016, United States
FOMAT Medical Research

Oxnard, California, 93030, United States
Fresno Clinical Research Center

Fresno, California, 92720, United States
G+C Research Group

Miami, Florida, 33126, United States
Galenus Group

Lehigh Acres, Florida, 33976, United States
Houston Research Institute

Houston, Texas, 77079, United States
Inland Empire Clinical Trials

Rialto, California, 92377, United States
Kansas City Research Institute

Kansas City, Missouri, 64131, United States
Knowledge Research Center

Orange, California, 92868, United States
Lillestol Research LLC

Fargo, North Dakota, 58104, United States
LinQ Research, LLC

Pearland, Texas, 77584, United States
Liver Institute NorthWest

Seattle, Washington, 98105, United States
Liver Institute PPLC

Tucson, Arizona, 85712, United States
Miami Clinical Research

Miami, Florida, 33155, United States
Olympus Family Medicine

Salt Lake City, Utah, 84117, United States
Panex Clinical Research

Miami Lakes, Florida, 33014, United States
Pinnacle Clinical Research - Austin

Austin, Texas, 78757, United States
Pinnacle Clinical Research - Georgetown

Georgetown, Texas, 78626, United States
Pinnacle Clinical Research - San Antonio

San Antonio, Texas, 78229, United States
Progressive Medical Research

Port Orange, Florida, 32127, United States
QLMC

Tucson, Arizona, 85712, United States
Quality Research, Inc

San Antonio, Texas, 78209, United States
South Ogden Family Medicine

South Ogden, Utah, 84405, United States
South Texas Research Institute-Brownsville

Brownsville, Texas, 78520, United States
South Texas Research Institute-Edinburg

Edinburg, Texas, 75839, United States
Southwest General Healthcare Center

Fort Myers, Florida, 33907, United States
Tandem Clinical Research

Marrero, Louisiana, 70072, United States
Texas Liver Institute - Austin

Austin, Texas, 78757, United States
Velocity Clinical Research

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research - Waco

Waco, Texas, 76710, United States

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