New shot shows promise for fatty liver disease in early trial
NCT ID NCT04880031
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a drug called BOS-580 (efimosfermin) in 231 obese adults with or at risk for NASH, a serious fatty liver disease. Participants received either the drug or a placebo as a shot under the skin. The main goal was to check safety and side effects. The trial is now complete, and results will help decide if further testing is warranted.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Efimosfermin (also called BOS-580), a drug given as a shot under the skin
What this could lead to
If successful, this could point toward a new treatment option for NASH, a liver disease with no approved therapies.
What could go wrong
This is an early Phase 2a trial focused on safety, not proof of effectiveness. The results may not lead to a working treatment, and side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Accelemed Research
Austin, Texas, 78745, United States
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Admed Research
Miami, Florida, 33173, United States
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Advanced Clinical Research
Miami, Florida, 33156, United States
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Alliance Research Institute
Canoga Park, California, 91304, United States
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American Research Corporation at Texas Liver Institute
San Antonio, Texas, 78215, United States
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Apex Mobile Clinical Research
Bellaire, Texas, 77401, United States
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Arizona Liver Health
Chandler, Arizona, 85224, United States
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Arizona Liver Health
Peoria, Arizona, 85381, United States
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Arizona Liver Health
Tucson, Arizona, 85712, United States
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Ark Clinical Research
Fountain Valley, California, 92708, United States
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Catalina Research Institute
Montclair, California, 91763, United States
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Central Research Associates
Birmingham, Alabama, 35205, United States
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Century Research
Miami, Florida, 33173, United States
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Charter Research
Orlando, Florida, 32803, United States
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Coastal Research Institute, LLC
Fayetteville, North Carolina, 28304, United States
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Covenant Metabolic Specialists - Fort Myers
Fort Myers, Florida, 33912, United States
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Covenant Metabolic Specialists - Sarasota
Sarasota, Florida, 34240, United States
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Entrust Clinical Research Center
Kendall, Florida, 33176, United States
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Evolution Clinical Trials
Hialeah Gardens, Florida, 33016, United States
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FOMAT Medical Research
Oxnard, California, 93030, United States
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Fresno Clinical Research Center
Fresno, California, 92720, United States
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G+C Research Group
Miami, Florida, 33126, United States
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Galenus Group
Lehigh Acres, Florida, 33976, United States
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Houston Research Institute
Houston, Texas, 77079, United States
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Inland Empire Clinical Trials
Rialto, California, 92377, United States
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Kansas City Research Institute
Kansas City, Missouri, 64131, United States
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Knowledge Research Center
Orange, California, 92868, United States
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Lillestol Research LLC
Fargo, North Dakota, 58104, United States
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LinQ Research, LLC
Pearland, Texas, 77584, United States
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Liver Institute NorthWest
Seattle, Washington, 98105, United States
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Liver Institute PPLC
Tucson, Arizona, 85712, United States
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Miami Clinical Research
Miami, Florida, 33155, United States
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Olympus Family Medicine
Salt Lake City, Utah, 84117, United States
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Panex Clinical Research
Miami Lakes, Florida, 33014, United States
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Pinnacle Clinical Research - Austin
Austin, Texas, 78757, United States
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Pinnacle Clinical Research - Georgetown
Georgetown, Texas, 78626, United States
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Pinnacle Clinical Research - San Antonio
San Antonio, Texas, 78229, United States
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Progressive Medical Research
Port Orange, Florida, 32127, United States
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QLMC
Tucson, Arizona, 85712, United States
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Quality Research, Inc
San Antonio, Texas, 78209, United States
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South Ogden Family Medicine
South Ogden, Utah, 84405, United States
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South Texas Research Institute-Brownsville
Brownsville, Texas, 78520, United States
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South Texas Research Institute-Edinburg
Edinburg, Texas, 75839, United States
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Southwest General Healthcare Center
Fort Myers, Florida, 33907, United States
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Tandem Clinical Research
Marrero, Louisiana, 70072, United States
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Texas Liver Institute - Austin
Austin, Texas, 78757, United States
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Velocity Clinical Research
East Greenwich, Rhode Island, 02818, United States
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Velocity Clinical Research - Waco
Waco, Texas, 76710, United States