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New drug aims to melt liver fat in NASH patients

NCT ID NCT05842512

Recruiting now Disease control Sponsor: Polaris Group Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a drug called ADI-PEG 20 against a placebo in 60 adults with nonalcoholic steatohepatitis (NASH), a type of fatty liver disease. Participants receive injections over 24 weeks, and doctors measure changes in liver fat using MRI. The goal is to see if the drug can safely reduce liver fat and improve the condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ADI-PEG 20 (pegargiminase)
What this could lead to
If it works, this could point toward a new treatment for nonalcoholic steatohepatitis (NASH), a serious fatty liver disease.
What could go wrong
This is an early phase 2 trial with only 60 people, so results may not be conclusive. The drug may not reduce liver fat better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NONALCOHOLIC STEATOHEPATITIS (NASH)

Contacts and locations

Locations

  • Chang Gung Medical Foundation-Kaohsiung (CGMF-KS)

    RECRUITING

    Kaohsiung, Taiwan, 833, Taiwan

  • Chang Gung Medical Foundation-Keelung (CGMF-KL)

    RECRUITING

    Keelung, Taiwan, 204, Taiwan

  • Chang Gung Medical Foundation-Linkou (CGMF-LK)

    RECRUITING

    Taoyuan, Taiwan, 333, Taiwan

  • Ditmanson Medical Foundation Chiayi Christian Hospital；Chiayi Christian Hospital (CYCH)

    RECRUITING

    Chiayi City, Taiwan, 600566, Taiwan

  • E-Da Hospital (EDH)

    RECRUITING

    Kaohsiung, Taiwan, 824, Taiwan

  • Fu Jen Catholic University Hospital (FJCUH)

    RECRUITING

    Taipei, Taiwan, 243, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital(KMUH)

    RECRUITING

    Kaohsiung, Taiwan, 807, Taiwan

  • National Cheng Kung University Hospital (NCKUH)

    RECRUITING

    Tainan, Taiwan, 704, Taiwan

  • National Taiwan University Hospital (NTUH)

    RECRUITING

    Taipei, Taiwan, 100229, Taiwan

  • Taipei Veterans General Hospital (TPVGH)

    RECRUITING

    Taipei, Taiwan, 112201, Taiwan

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