New injection could shrink nasal polyps without surgery

NCT ID NCT05274750

Completed Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested a biologic drug called depemokimab in 276 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as an injection under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks to see if the drug can improve symptoms and reduce the need for surgery or steroids.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Depemokimab (a biologic drug given as an injection under the skin)

What this could lead to

If it works, this could offer a new treatment option to reduce nasal polyps and improve breathing without needing surgery or steroids.

What could go wrong

This is a single phase 3 trial with 276 participants, so results may not apply to everyone. The drug may cause side effects like injection reactions or infections.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

nasal cavity polyp

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NASAL POLYPS

Contacts and locations

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Locations

GSK Investigational Site

Tucson, Arizona, 85704, United States
GSK Investigational Site

Buena Park, California, 90621, United States
GSK Investigational Site

Los Angeles, California, 90006, United States
GSK Investigational Site

San Diego, California, 91942, United States
GSK Investigational Site

Stanford, California, 94304, United States
GSK Investigational Site

Temecula, California, 92592, United States
GSK Investigational Site

Aurora, Colorado, 80045, United States
GSK Investigational Site

Gainesville, Florida, 32605, United States
GSK Investigational Site

Tamarac, Florida, 33321, United States
GSK Investigational Site

Tampa, Florida, 33613, United States
GSK Investigational Site

Meridian, Idaho, 83642, United States
GSK Investigational Site

Meridian, Idaho, 83706, United States
GSK Investigational Site

Chicago, Illinois, 60612, United States
GSK Investigational Site

Lexington, Kentucky, 40509, United States
GSK Investigational Site

Louisville, Kentucky, 40205, United States
GSK Investigational Site

Boston, Massachusetts, 02135, United States
GSK Investigational Site

New Brunswick, New Jersey, 08901, United States
GSK Investigational Site

Great Neck, New York, 11021, United States
GSK Investigational Site

Rochester, New York, 14642, United States
GSK Investigational Site

Chapel Hill, North Carolina, 27599, United States
GSK Investigational Site

Cincinnati, Ohio, 45267, United States
GSK Investigational Site

Tulsa, Oklahoma, 74137, United States
GSK Investigational Site

Bethlehem, Pennsylvania, 18017, United States
GSK Investigational Site

Providence, Rhode Island, 02914, United States
GSK Investigational Site

Dallas, Texas, 75390-9035, United States
GSK Investigational Site

Richmond, Virginia, 23235, United States
GSK Investigational Site

Buenos Aires, 1023, Argentina
GSK Investigational Site

Buenos Aires, C1425BEN, Argentina
GSK Investigational Site

Buenos Aires, C1426ABP, Argentina
GSK Investigational Site

Ciudad Autonoma de Bueno, C1121ABE, Argentina
GSK Investigational Site

Florida, B1602DOH, Argentina
GSK Investigational Site

La Plata, 1900, Argentina
GSK Investigational Site

Mar del Plata, 7600, Argentina
GSK Investigational Site

Mendoza, 5500, Argentina
GSK Investigational Site

Mendoza, M5500CCG, Argentina
GSK Investigational Site

Rosario, S2000DBS, Argentina
GSK Investigational Site

Ghent, 9000, Belgium
GSK Investigational Site

Hamilton, Ontario, L8L 2X2, Canada
GSK Investigational Site

London, Ontario, N6A 4V2, Canada
GSK Investigational Site

Ottawa, Ontario, K1H 1E4, Canada
GSK Investigational Site

Montreal, Quebec, H2V 2K1, Canada
GSK Investigational Site

Montreal, Quebec, H2X 3E4, Canada
GSK Investigational Site

Québec, Quebec, G1S 4L8, Canada
GSK Investigational Site

Québec, Quebec, G1V 4W2, Canada
GSK Investigational Site

Beijing, 100191, China
GSK Investigational Site

Beijing, 100730, China
GSK Investigational Site

Dongguan, 523326, China
GSK Investigational Site

Jingzhou, 434020, China
GSK Investigational Site

Nanchang, 330006, China
GSK Investigational Site

Qingdao, 266061, China
GSK Investigational Site

Shanghai, 200065, China
GSK Investigational Site

Taiyuan, 300201, China
GSK Investigational Site

Wenzhou, 325000, China
GSK Investigational Site

Wuhan, 430022, China
GSK Investigational Site

Yantai, 264000, China
GSK Investigational Site

Clermont-Ferrand, 63003, France
GSK Investigational Site

Créteil, 94010, France
GSK Investigational Site

Grenoble, 38043, France
GSK Investigational Site

La Roche-sur-Yon, 85925, France
GSK Investigational Site

La Rochelle, 17019, France
GSK Investigational Site

Marseille, 13005, France
GSK Investigational Site

Montpellier, 34295, France
GSK Investigational Site

Nantes, 44093, France
GSK Investigational Site

Pontoise, 95300, France
GSK Investigational Site

Toulouse, 31059, France
GSK Investigational Site

Valenciennes, 59322, France
GSK Investigational Site

Bonn, 53127, Germany
GSK Investigational Site

Dortmund, 44137, Germany
GSK Investigational Site

Dresden, 01139, Germany
GSK Investigational Site

Dresden, 01307, Germany
GSK Investigational Site

Düsseldorf, 40225, Germany
GSK Investigational Site

Düsseldorf, 40549, Germany
GSK Investigational Site

Marburg, 35043, Germany
GSK Investigational Site

München, 81377, Germany
GSK Investigational Site

Münster, 48149, Germany
GSK Investigational Site

Wiesbaden, 65183, Germany
GSK Investigational Site

Ehime, 790-0024, Japan
GSK Investigational Site

Ehime, 798-8510, Japan
GSK Investigational Site

Fukui, 910-1193, Japan
GSK Investigational Site

Fukuoka, 806-8501, Japan
GSK Investigational Site

Ishikawa, 920-0293, Japan
GSK Investigational Site

Kanagawa, 231-8682, Japan
GSK Investigational Site

Kanagawa, 250-8558, Japan
GSK Investigational Site

Kumamoto, 860-0814, Japan
GSK Investigational Site

Kyoto, 600-8216, Japan
GSK Investigational Site

Mie, 514-8507, Japan
GSK Investigational Site

Nagano, 392-8510, Japan
GSK Investigational Site

Osaka, 560-0082, Japan
GSK Investigational Site

Osaka, 570-8507, Japan
GSK Investigational Site

Tokyo, 160-0023, Japan
GSK Investigational Site

Tokyo, 173-0026, Japan
GSK Investigational Site

Amsterdam, 1105 AZ, Netherlands
GSK Investigational Site

Leiden, 2353 GA, Netherlands
GSK Investigational Site

Barcelona, 08022, Spain
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

Jerez de la Frontera, 11407, Spain
GSK Investigational Site

Madrid, 28034, Spain
GSK Investigational Site

Madrid, 28040, Spain
GSK Investigational Site

Pamplona, 31008, Spain
GSK Investigational Site

Seville, 41009, Spain
GSK Investigational Site

Valladolid, 47005, Spain
GSK Investigational Site

Zaragoza, 50009, Spain
GSK Investigational Site

Great Yarmouth, NR31 6LA, United Kingdom
GSK Investigational Site

Stevenage, SG1 4AB, United Kingdom
GSK Investigational Site

Wigan, WN1 2NN, United Kingdom