Year-Long shot tested to shrink nasal polyps and improve breathing

NCT ID NCT05274750

Completed Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

Summary

This study tested an investigational long-acting injection called depemokimab for adults with chronic sinusitis and troublesome nasal polyps. The goal was to see if regular injections over one year could safely reduce polyp size, improve nasal blockage, and lessen symptoms like loss of smell and runny nose. Researchers compared the drug to a placebo in 276 participants to measure changes in symptoms and the need for surgery.

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Contacts and locations

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Locations

GSK Investigational Site

Tucson, Arizona, 85704, United States
GSK Investigational Site

Buena Park, California, 90621, United States
GSK Investigational Site

Los Angeles, California, 90006, United States
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San Diego, California, 91942, United States
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Stanford, California, 94304, United States
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Temecula, California, 92592, United States
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Aurora, Colorado, 80045, United States
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Gainesville, Florida, 32605, United States
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Tamarac, Florida, 33321, United States
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Tampa, Florida, 33613, United States
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Meridian, Idaho, 83642, United States
GSK Investigational Site

Meridian, Idaho, 83706, United States
GSK Investigational Site

Chicago, Illinois, 60612, United States
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Lexington, Kentucky, 40509, United States
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Louisville, Kentucky, 40205, United States
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Boston, Massachusetts, 02135, United States
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New Brunswick, New Jersey, 08901, United States
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Great Neck, New York, 11021, United States
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Rochester, New York, 14642, United States
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Chapel Hill, North Carolina, 27599, United States
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Cincinnati, Ohio, 45267, United States
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Tulsa, Oklahoma, 74137, United States
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Bethlehem, Pennsylvania, 18017, United States
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Providence, Rhode Island, 02914, United States
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Dallas, Texas, 75390-9035, United States
GSK Investigational Site

Richmond, Virginia, 23235, United States
GSK Investigational Site

Buenos Aires, 1023, Argentina
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Buenos Aires, C1425BEN, Argentina
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Buenos Aires, C1426ABP, Argentina
GSK Investigational Site

Ciudad Autonoma de Bueno, C1121ABE, Argentina
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Florida, B1602DOH, Argentina
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La Plata, 1900, Argentina
GSK Investigational Site

Mar del Plata, 7600, Argentina
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Mendoza, 5500, Argentina
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Mendoza, M5500CCG, Argentina
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Rosario, S2000DBS, Argentina
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Ghent, 9000, Belgium
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Hamilton, Ontario, L8L 2X2, Canada
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London, Ontario, N6A 4V2, Canada
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Ottawa, Ontario, K1H 1E4, Canada
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Montreal, Quebec, H2V 2K1, Canada
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Montreal, Quebec, H2X 3E4, Canada
GSK Investigational Site

Québec, Quebec, G1S 4L8, Canada
GSK Investigational Site

Québec, Quebec, G1V 4W2, Canada
GSK Investigational Site

Beijing, 100191, China
GSK Investigational Site

Beijing, 100730, China
GSK Investigational Site

Dongguan, 523326, China
GSK Investigational Site

Jingzhou, 434020, China
GSK Investigational Site

Nanchang, 330006, China
GSK Investigational Site

Qingdao, 266061, China
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Shanghai, 200065, China
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Taiyuan, 300201, China
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Wenzhou, 325000, China
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Wuhan, 430022, China
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Yantai, 264000, China
GSK Investigational Site

Clermont-Ferrand, 63003, France
GSK Investigational Site

Créteil, 94010, France
GSK Investigational Site

Grenoble, 38043, France
GSK Investigational Site

La Roche-sur-Yon, 85925, France
GSK Investigational Site

La Rochelle, 17019, France
GSK Investigational Site

Marseille, 13005, France
GSK Investigational Site

Montpellier, 34295, France
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Nantes, 44093, France
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Pontoise, 95300, France
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Toulouse, 31059, France
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Valenciennes, 59322, France
GSK Investigational Site

Bonn, 53127, Germany
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Dortmund, 44137, Germany
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Dresden, 01139, Germany
GSK Investigational Site

Dresden, 01307, Germany
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Düsseldorf, 40225, Germany
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Düsseldorf, 40549, Germany
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Marburg, 35043, Germany
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München, 81377, Germany
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Münster, 48149, Germany
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Wiesbaden, 65183, Germany
GSK Investigational Site

Ehime, 790-0024, Japan
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Ehime, 798-8510, Japan
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Fukui, 910-1193, Japan
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Fukuoka, 806-8501, Japan
GSK Investigational Site

Ishikawa, 920-0293, Japan
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Kanagawa, 231-8682, Japan
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Kanagawa, 250-8558, Japan
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Kumamoto, 860-0814, Japan
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Kyoto, 600-8216, Japan
GSK Investigational Site

Mie, 514-8507, Japan
GSK Investigational Site

Nagano, 392-8510, Japan
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Osaka, 560-0082, Japan
GSK Investigational Site

Osaka, 570-8507, Japan
GSK Investigational Site

Tokyo, 160-0023, Japan
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Tokyo, 173-0026, Japan
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Amsterdam, 1105 AZ, Netherlands
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Leiden, 2353 GA, Netherlands
GSK Investigational Site

Barcelona, 08022, Spain
GSK Investigational Site

Barcelona, 08036, Spain
GSK Investigational Site

Jerez de la Frontera, 11407, Spain
GSK Investigational Site

Madrid, 28034, Spain
GSK Investigational Site

Madrid, 28040, Spain
GSK Investigational Site

Pamplona, 31008, Spain
GSK Investigational Site

Seville, 41009, Spain
GSK Investigational Site

Valladolid, 47005, Spain
GSK Investigational Site

Zaragoza, 50009, Spain
GSK Investigational Site

Great Yarmouth, NR31 6LA, United Kingdom
GSK Investigational Site

Stevenage, SG1 4AB, United Kingdom
GSK Investigational Site

Wigan, WN1 2NN, United Kingdom

Conditions

Explore the condition pages connected to this study.

NASAL POLYPS