New hope for head and neck cancer: drug may prevent recurrence after chemoradiation

NCT ID NCT06256588

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether the drug dostarlimab, given after standard chemoradiation, can help prevent head and neck cancer from coming back or spreading. About 864 adults with advanced but not surgically removable head and neck cancer will receive either dostarlimab or a placebo. The main goal is to see if dostarlimab improves the time patients stay cancer-free.

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Conditions

The condition(s) this trial relates to.

head and neck neoplasm Head and Neck Neoplasms head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEOPLASMS, HEAD AND NECK

Contacts and locations

Locations

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Jonesboro, Arkansas, 72401, United States
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Los Angeles, California, 90095, United States
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Solvang, California, 93463, United States
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Stockton, California, 95204, United States
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Torrance, California, 90505, United States
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Farmington, Connecticut, 06030-1628, United States
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New Haven, Connecticut, 06520, United States
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Washington D.C., District of Columbia, 20010, United States
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St. Petersburg, Florida, 33709, United States
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Tamarac, Florida, 33321, United States
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Atlanta, Georgia, 30322, United States
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Fort Wayne, Indiana, 46804, United States
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Iowa City, Iowa, 52242, United States
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Lexington, Kentucky, 40536, United States
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Columbia, Maryland, 21044, United States
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Worcester, Massachusetts, 01655-0002, United States
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St Louis, Missouri, 63110, United States
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Omaha, Nebraska, 68114, United States
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New York, New York, 10032, United States
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The Bronx, New York, 10468, United States
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Canton, Ohio, 44718, United States
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Cincinnati, Ohio, 45219, United States
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Tulsa, Oklahoma, 74146, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Charleston, South Carolina, 29425, United States
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Greenville, South Carolina, 29607, United States
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Chattanooga, Tennessee, 37404, United States
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Germantown, Tennessee, 38138, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75246, United States
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Fort Worth, Texas, 76104, United States
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San Antonio, Texas, 78217, United States
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Fredericksburg, Virginia, 22408, United States
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Wytheville, Virginia, 24382, United States
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Tacoma, Washington, 98405, United States
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Buenos Aires, 1023, Argentina
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Buenos Aires, C1425, Argentina
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Buenos Aires, C1437GZT, Argentina
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Ciudad Autonoma de Buenos Aire, C1426, Argentina
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Córdoba, 5000, Argentina
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Florida, 1602, Argentina
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Rosario, S2002, Argentina
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San Juan, J5400, Argentina
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San Miguel de Tucumán, T4000GTB, Argentina
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Viedma, R8500ACE, Argentina
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Blacktown, New South Wales, 2148, Australia
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Douglas, Queensland, 4814, Australia
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Herston, Queensland, 4029, Australia
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Ballarat, Victoria, 3350, Australia
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Geelong, Victoria, 3220, Australia
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Melbourne, Victoria, 3004, Australia
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Brussels, 1200, Belgium
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Charleroi, 6060, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Liège, 4000, Belgium
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Yvoir, 5530, Belgium
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Barretos, 14784-400, Brazil
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Belo Horizonte, 30110-022, Brazil
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Florianópolis, 88020-210, Brazil
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Ijuí, 98700-000, Brazil
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Jaú, 17210-120, Brazil
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Joinville, 89201-260, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90610-000, Brazil
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Salvador, 41253-190, Brazil
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Salvador, 41950-640, Brazil
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São José do Rio Preto, 15090-200, Brazil
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São Paulo, 01246-000, Brazil
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Vitória, 29043-260, Brazil
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Hamilton, Ontario, L8V 5C2, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Chongqing, Chongqing Municipality, 400030, China
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Baoding, Hebei, 071000, China
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Nanyang, Henan, 473005, China
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Beijing, 100036, China
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Changsha, 410013, China
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Changzhou, 213032, China
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Chengdu, 610000, China
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Chengdu, 610041, China
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Dongguan, 523059, China
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Fuzhou, 350005, China
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Fuzhou, 350014, China
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Guangzhou, 510120, China
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Guangzhou, 510503, China
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Hangzhou, 310003, China
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Hangzhou, 310022, China
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Hefei, 230001, China
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Hengyang, 421000, China
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Jinan, 250117, China
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Kunming, 650106, China
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Lanzhou, 730030, China
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Linyi, 276002, China
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Nanchang, 330006, China
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Nanchang, 330029, China
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Nanning, 530021, China
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Shanghai, 200032, China
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Taiyuan, 030013, China
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Wuhan, 430030, China
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Wuhan, 430079, China
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Xiamen, 361004, China
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Xuzhou, 221004, China
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Zhengzhou, 450052, China
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Zhuhai, 519001, China
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Olomouc, 779 00, Czechia
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Prague, 10034, Czechia
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Prague, 150 08, Czechia
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Prague, 180 81, Czechia
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Zlín, 76275, Czechia
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Ars-Laquenexy, 57530, France
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Caen, 14075, France
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Dijon, 21079, France
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Marseille, 13005, France
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Poitiers, 86021, France
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Quimper, 29000, France
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Rennes, 35042, France
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Rouen, 76038, France
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Vandœuvre-lès-Nancy, 54519, France
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Augsburg, 86156, Germany
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Berlin, 12351, Germany
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Berlin, 13353, Germany
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Erlangen, 91054, Germany
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Essen, 45147, Germany
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Giessen, 35392, Germany
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Hamburg, 22087, Germany
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Neuruppin, 16816, Germany
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Straubing, 94315, Germany
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Athens, 115 22, Greece
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Athens, 12462, Greece
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Larissa, 41100, Greece
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Thessaloniki, 564 29, Greece
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Győr, 9023, Hungary
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Kaposvár, 7400, Hungary
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Nyíregyháza, H-4400, Hungary
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Mumbai, Maharashtra, 400071, India
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Pune, Maharashtra, 411001, India
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Bengaluru, 560066, India
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Bhubaneswar, 751019, India
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Gurgaon, 122001, India
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Hyderabad, 500004, India
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Mumbai, 400012, India
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Nashik, 422002, India
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Nehru Nagar Belagavi Karnataka 590010, 590010, India
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Surat, 395002, India
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Vijayawada, 520002, India
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Ashdod, 7747629, Israel
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Haifa, 3109601, Israel
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Jerusalem, 9112001, Israel
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Tel Aviv, 64239, Israel
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Bolzano, Prov. Aut. Bolzano-Alto Adige, 39100, Italy
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Bologna, 40139, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Pavia, 27100, Italy
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Prato, 59100, Italy
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Roma, 00161, Italy
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Roma, 00168, Italy
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Rozzano MI, 20089, Italy
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Savona, 17100, Italy
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Aichi, 464-8681, Japan
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Aomori, 036-8563, Japan
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Chiba, 260-8717, Japan
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Chiba, 277-8577, Japan
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Ehime, 791-0280, Japan
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Fukuoka, 812-8582, Japan
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Gunma, 371-8511, Japan
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Hokkaido, 060-8648, Japan
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Hyōgo, 650-0017, Japan
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Hyōgo, 673-8558, Japan
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Kagoshima, 890-8520, Japan
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Kanagawa, 236-0004, Japan
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Kanagawa, 252-0375, Japan
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Kanagawa, 259-1193, Japan
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Kyoto, 612-8555, Japan
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Miyagi, 981-1293, Japan
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Niigata, 951-8520, Japan
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Numakunai, 028-3695, Japan
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Okinawa, 901-2725, Japan
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Osaka, 541-8567, Japan
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Saitama, 350-1298, Japan
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Shizuoka, 411-8777, Japan
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Tokyo, 105-8471, Japan
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Tokyo, 113-8519, Japan
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Tokyo, 152-8902, Japan
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Tokyo, 160-0023, Japan
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Tottori, 683-8504, Japan
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Guadajalara, 44280, Mexico
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Guadalajara, 44650, Mexico
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Mexico City, 06760, Mexico
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Mexico City, 11510, Mexico
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Monterrey, 66260, Mexico
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Oaxaca City, 68020, Mexico
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Bergen, 5021, Norway
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Oslo, 0379, Norway
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Troms, 9038, Norway
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Bielsko-Biala, 43-300, Poland
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Gliwice, 44-102, Poland
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Katowice, 40-514, Poland
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Olsztyn, 10-228, Poland
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Przemyśl, 37-700, Poland
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Siedlce, 08-110, Poland
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Warsaw, 04-141, Poland
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Coimbra, 3000-075, Portugal
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Faro, 8000-386, Portugal
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Lisbon, 1649-035, Portugal
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Lisbon, 1998-018, Portugal
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Matosinhos Municipality, 4464-509, Portugal
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Porto, 4200-072, Portugal
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Porto, 4200-319, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Bucharest, 013823, Romania
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Bucharest, 020142, Romania
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Craiova, 200508, Romania
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Craiova, 200542, Romania
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Floreşti, 407280, Romania
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Iași, 700483, Romania
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Oradea, 410469, Romania
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Piteşti, 110283, Romania
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Suceava, 720214, Romania
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Timișoara, 300239, Romania
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Riyadh, 12372, Saudi Arabia
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Riyadh, Saudi Arabia
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Singapore, 168583, Singapore
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Singapore, 308433, Singapore
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Busan, 602-030, South Korea
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Pusan, 49241, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Seoul, 110 744, South Korea
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Suwon Gyeonggi-do, 16247, South Korea
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BaracaldoVizcaya, 48903, Spain
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Barcelona, 08023, Spain
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Cartagena Murcia, 30202, Spain
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HebrOn, 08035, Spain
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Jerez de la Frontera, 11407, Spain
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L'Hospitalet de Llobrega, 08908, Spain
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Lugo, 27003, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Madrid, 28046, Spain
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Pamplona, 31008, Spain
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Salamanca, 37007, Spain
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Santander, 39008, Spain
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Zaragoza, 50009, Spain
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Gothenburg, SE-413 45, Sweden
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Stockholm, SE-171 64, Sweden
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Uppsala, SE-751 85, Sweden
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Basel, 4031, Switzerland
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Fribourg, 1708, Switzerland
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Geneva, 1211, Switzerland
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Lausanne, 1011, Switzerland
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Zurich, 8091, Switzerland
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Changhua, 500, Taiwan
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Kaohsiung City, 833, Taiwan
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Taichung, 40447, Taiwan
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Taipei, 100, Taiwan
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Adapazarı, Turkey (Türkiye)
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06100, Turkey (Türkiye)
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Ankara, 06520, Turkey (Türkiye)
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Antalya, 7050, Turkey (Türkiye)
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Istanbul, 34010, Turkey (Türkiye)
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Istanbul, 34662, Turkey (Türkiye)
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Istanbul, Şişli, 34384, Turkey (Türkiye)
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Abu Dhabi, United Arab Emirates
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Al Ain City, United Arab Emirates
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Dubai, United Arab Emirates
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Edinburgh, EH4 2XU, United Kingdom
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Gloucester, GL1 3NN, United Kingdom
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London, SW3 6JJ, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Wolverhampton, WV10 0QP, United Kingdom

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