New combo aims to boost immune attack on HPV-Driven head and neck cancer
NCT ID NCT06790966
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tests whether adding an experimental immunotherapy called PDS0101 to the standard drug pembrolizumab helps people with advanced HPV16-positive head and neck cancer live longer. About 252 participants will receive either the combination or pembrolizumab alone. The study is active but no longer recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PDS0101 (a vaccine-like immunotherapy) and pembrolizumab (an immunotherapy drug)
What this could lead to
If it works, this combination could become a new first-line treatment that helps people with HPV16-positive head and neck cancer live longer and keep their cancer under control.
What could go wrong
This is a Phase 3 trial, but it's still experimental. The combination may not work better than pembrolizumab alone, and could cause additional side effects like immune reactions.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for UNRESECTABLE HEAD AND NECK SQUAMOUS CELL CARCINOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Emory University - Winship Cancer Institute (WCI)
Atlanta, Georgia, 30322, United States
-
Florida Cancer Affiliates - Ocala Oncology
Ocala, Florida, 34474, United States
-
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19103, United States
-
Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
-
Marin Cancer Care
Greenbrae, California, 94904, United States
-
Mayo Clinic Arizona
Phoenix, Arizona, 85054, United States
-
Mayo Clinic Florida
Jacksonville, Florida, 32224, United States
-
Mayo Clinic Rochester
Rochester, Minnesota, 55905, United States
-
Medical University of South Carolina
Charleston, South Carolina, 29407, United States
-
Norton Cancer Institute
Louisville, Kentucky, 40202, United States
-
Penn State Health
Hershey, Pennsylvania, 17033, United States
-
SCRI - Florida Cancer Specialists
Orlando, Florida, 32827, United States
-
Texas Oncology
Austin, Texas, 78705, United States
-
Texas Oncology-Northeast Texas
Tyler, Texas, 75702, United States
-
The Ohio State University- James Cancer Hospital
Columbus, Ohio, 43210, United States
-
UT Health San Antonio
San Antonio, Texas, 78229, United States
-
University of California, Orange
Orange, California, 92686, United States
-
University of Kansas
Westwood, Kansas, 66205, United States
-
University of Kentucky
Lexington, Kentucky, 40536, United States
-
University of Louisville
Louisville, Kentucky, 40202, United States
-
University of Maryland
Baltimore, Maryland, 21201, United States
-
University of Michigan
Ann Arbor, Michigan, 48109, United States
-
University of North Carolina
Chapel Hill, North Carolina, 27599-7025, United States
-
University of Tennessee Medical Center
Knoxville, Tennessee, 37920, United States
-
University of Virginia Health System
Charlottesville, Virginia, 22903, United States
-
Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
-
West Virginia University Cancer Center
Morgantown, West Virginia, 26506, United States
-
Yale University
New Haven, Connecticut, 06510, United States