Could a lupus drug help scleroderma lungs?

NCT ID NCT05878717

Recruiting now Disease control Sponsor: GlaxoSmithKline Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether belimumab (Benlysta), a drug already used for lupus, can improve lung function and skin thickening in adults with scleroderma-related interstitial lung disease. About 300 participants will receive either belimumab or a placebo added to their standard care. The main goal is to see if lung capacity changes after one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: belimumab (Benlysta)
What this could lead to: If it works, this could offer a new treatment option to slow lung damage and improve skin and quality of life in people with scleroderma-related lung disease.
What could go wrong: This is a mid-stage trial, so results are uncertain. Belimumab may not improve lung function more than placebo, and side effects like infections are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse scleroderma interstitial lung disease pulmonary systemic sclerosis systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCLERODERMA, SYSTEMIC SYSTEMIC SCLEROSIS ASSOCIATED INTERSTITIAL LUNG DISEASE

Contacts and locations

Locations

GSK Investigational Site
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Phoenix, Arizona, 85027, United States
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Scottsdale, Arizona, 85258, United States
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Scottsdale, Arizona, 85259, United States
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Tucson, Arizona, 85724, United States
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Los Angeles, California, 90095, United States
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Los Angeles, California, 90095, United States
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Los Angeles, California, 90301, United States
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Upland, California, 91786, United States
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Aurora, Colorado, 80033, United States
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Washington D.C., District of Columbia, 20007, United States
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Jacksonville, Florida, 32610, United States
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Miami, Florida, 33144, United States
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Chicago, Illinois, 60611, United States
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Baltimore, Maryland, 21224, United States
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Ann Arbor, Michigan, 48109, United States
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New Brunswick, New Jersey, 08901, United States
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New York, New York, 10021, United States
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New York, New York, 11201, United States
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Potsdam, New York, 13676, United States
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Cincinnati, Ohio, 45206, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19140, United States
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Denison, Texas, 75020, United States
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El Paso, Texas, 79902, United States
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Houston, Texas, 77030, United States
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Buenos Aires, Argentina
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Ciudad Autonoma Buenos Aires, C1015ABO, Argentina
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Ciudad Autonoma de Buenos Aire, Argentina
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Liverpool, New South Wales, 2170, Australia
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Adelaide, South Australia, 5000, Australia
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Woodville, South Australia, 5011, Australia
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Fitzroy, Victoria, 3065, Australia
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Ghent, 9000, Belgium
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Liège, 4000, Belgium
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Belo Horizonte, 30150221, Brazil
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Curitiba, 80440-080, Brazil
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Juiz de Fora, 36010-570, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, Brazil
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Salvador, 40.150-150, Brazil
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São Paulo, 01308-050, Brazil
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São Paulo, 04038-002, Brazil
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Beijing, 100020, China
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Beijing, 100191, China
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Beijing, 100730, China
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Beijing, 100730, China
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Changchun, 130021, China
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Chengdu, 610041, China
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Chengdu, 610072, China
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Luzhou, 648000, China
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Mianyang, China
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Nanjing, 210008, China
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Nanjing, 210029, China
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Nanning, 530000, China
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Shanghai, 200001, China
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Shanghai, 200040, China
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Shenyang, 110001, China
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Xi'an, 710061, China
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Zhuzhou, 412007, China
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Aarhus, 8200, Denmark
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WITHDRAWN

Odense C, 5000, Denmark
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Turku, 20520, Finland
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Bobigny, 93000, France
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Brest, 29609, France
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Paris, 75014, France
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Paris, 75014, France
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Paris, 75651, France
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Toulouse, 31059, France
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Cologne, 51149, Germany
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Düsseldorf, 40225, Germany
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Mainz, 55131, Germany
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Minden, 32429, Germany
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Tübingen, 72076, Germany
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Athens, 11527, Greece
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Athens, 12462, Greece
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Heraklion Crete, 71110, Greece
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Larissa, 41110, Greece
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Thessaloniki, 546 36, Greece
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Haifa, 3436212, Israel
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Holon, 58100, Israel
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Kfar Saba, 44281, Israel
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Poria – Neve Oved, 15208, Israel
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Ramat Gan, 52621, Israel
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Tel Aviv, 6423906, Israel
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Ancona, 60126, Italy
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Bari, 70124, Italy
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Cagliari, 09042, Italy
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Catania, 95123, Italy
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Ferrara, 44124, Italy
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Florence, 50134, Italy
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Milan, 20122, Italy
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Modena, 41125, Italy
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Naples, 80131, Italy
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Orbassano to, 10043, Italy
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Padova, 35128, Italy
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Pavia, 27100, Italy
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Roma, 00161, Italy
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Roma, 00186, Italy
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Verona, 37134, Italy
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Gunma, 371-8511, Japan
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Hiroshima, 734-8551, Japan
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Hokkaido, 060-8543, Japan
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Hokkaido, 060-8648, Japan
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Kanagawa, 236-0051, Japan
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Miyagi, 980-8574, Japan
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Shizuoka, 431-3192, Japan
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Tokushima, 770-8503, Japan
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Tokyo, 113-8603, Japan
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Chihuahua City, 31000, Mexico
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Guadalajara, 44650, Mexico
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Mérida, CP 97070, Mexico
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Torreón, 27000, Mexico
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Seoul, 04763, South Korea
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Seoul, 05505, South Korea
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Seoul, 06591, South Korea
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Seoul, 140 887, South Korea
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Suwon Kyunggi-do, 16499, South Korea
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Barcelona, 08025, Spain
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Barcelona, 08035, Spain
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Bilbao, 48013, Spain
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Granada, 18016, Spain
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Madrid, 28007, Spain
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Madrid, 28046, Spain
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Seville, 41013, Spain
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Valencia, 46026, Spain
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VigoPontevedra, 36200, Spain
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Birmingham, B15 2GW, United Kingdom
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Leeds, LS7 4SA, United Kingdom
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London, NW3 2QG, United Kingdom
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Portsmouth, SG1 4AB, United Kingdom
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Wakefield, WF1 4DG, United Kingdom

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