New drug hope for scleroderma patients with lung complications

NCT ID NCT02682511

Ongoing Disease control Sponsor: Cumberland Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called ifetroban in 34 adults with a severe form of scleroderma (diffuse cutaneous systemic sclerosis) or scleroderma-related lung disease (pulmonary arterial hypertension). The main goal is to see if the drug is safe and whether it can improve lung function compared to a placebo. Participants are randomly assigned to receive ifetroban or a dummy pill, and neither they nor their doctors know which they are getting.

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Conditions

The condition(s) this trial relates to.

autoimmune disease connective tissue disorder diffuse cutaneous systemic sclerosis diffuse scleroderma limited cutaneous systemic sclerosis Pathologic Processes skin disorder systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE DISEASES CONNECTIVE TISSUE DISEASES PATHOLOGIC PROCESSES SCLERODERMA, DIFFUSE SCLERODERMA, LIMITED SCLERODERMA, SYSTEMIC SCLEROSIS, PROGRESSIVE SYSTEMIC SKIN DISEASES

Contacts and locations

Locations

B. J. Government Medical College

Pune, Maharashtra, 411001, India
Baylor Research Institute

Dallas, Texas, 75204-651, United States
Cleveland Clinic - Florida

Weston, Florida, 33331, United States
Hospital for Special Surgery

New York, New York, 10021, United States
Johns Hopkins University

Baltimore, Maryland, 21224, United States
KDH - Kokilaben Dhirubhai Ambani Hospital

Mumbai, Maharashtra, 400053, India
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical University of South Carolina

Charleston, South Carolina, 29403, United States
PGIMER

Chandigarh, Chandigarh, 160012, India
The Universtity of Arizona Arthrtis Center

Tucson, Arizona, 85724, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
UCLA

Los Angeles, California, 90095-1670, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States

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