New drug hope for scleroderma patients with lung complications

NCT ID NCT02682511

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called ifetroban in 34 adults with a severe form of scleroderma (diffuse cutaneous systemic sclerosis) or scleroderma-related lung disease (pulmonary arterial hypertension). The main goal is to see if the drug is safe and whether it can improve lung function compared to a placebo. Participants are randomly assigned to receive ifetroban or a dummy pill, and neither they nor their doctors know which they are getting.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autoimmune disease connective tissue disorder diffuse cutaneous systemic sclerosis diffuse scleroderma limited cutaneous systemic sclerosis Pathologic Processes skin disorder systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • B. J. Government Medical College

    Pune, Maharashtra, 411001, India

  • Baylor Research Institute

    Dallas, Texas, 75204-651, United States

  • Cleveland Clinic - Florida

    Weston, Florida, 33331, United States

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21224, United States

  • KDH - Kokilaben Dhirubhai Ambani Hospital

    Mumbai, Maharashtra, 400053, India

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29403, United States

  • PGIMER

    Chandigarh, Chandigarh, 160012, India

  • The Universtity of Arizona Arthrtis Center

    Tucson, Arizona, 85724, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, 19107, United States

  • UCLA

    Los Angeles, California, 90095-1670, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States