New lupus drug candidate enters first human tests
NCT ID NCT06576271
First seen Jan 04, 2026 · Last updated Jun 21, 2026 · Updated 31 times
Summary
This early-stage trial is testing a new drug called GSK4527363 in healthy volunteers and people with active lupus or lupus-related lung disease. The main goal is to check safety and how the body handles the drug. Around 142 participants will take part across four groups, including people of Chinese and Japanese descent.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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GSK Investigational Site
WITHDRAWNScottsdale, Arizona, 85260, United States
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GSK Investigational Site
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGLas Vegas, Nevada, 89154, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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GSK Investigational Site
RECRUITINGColumbus, Ohio, 44109, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
WITHDRAWNDallas, Texas, 75390, United States
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GSK Investigational Site
RECRUITINGBuenos Aires, C1280AEB, Argentina
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGRosario, S2002, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGSan Juan Bautista, B1888AAE, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGSan Miguel de Tucumán, T4000IHE, Argentina
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGPorto Alegre, Rio Grande do Sul, 90035-903, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGJuiz de Fora, 36010-570, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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GSK Investigational Site
RECRUITINGPorto Alegre, 90480000, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGSalvador, 40050-410, Brazil
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGBydgoszcz, 85-065, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGKrakow, 30-688, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGPoznan, 61-848, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGWarsaw, 02-665, Poland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGWroclaw, 50-556, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGBarcelona, 08916, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGBilbao, 48013, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGPamplona, 31008, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGSabadell Barcelona, 08208, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGValladolid, 47012, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGCambridge, CB2 0GG, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGLiverpool, L7 8YE, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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GSK Investigational Site
RECRUITINGMiddlesex, HA1 3UJ, United Kingdom
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GSK4527363
What this could lead to
If this early trial shows the drug is safe, it could lead to a new treatment option for people with lupus and related lung disease.
What could go wrong
This is a very early Phase 1 study with only 142 participants. The drug may not be safe or effective, and many early-stage drugs never make it to approval.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.