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Can nasal sprays replace antibiotics for sinus infections? major study aims to find out

NCT ID NCT06076304

Recruiting now Symptom relief Sponsor: Daniel Merenstein Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether antibiotics, nasal steroids, or nasal irrigation work best for treating sinus infections. About 3,720 adults with acute sinusitis will be randomly assigned to one of these treatments or a placebo. The goal is to see which approach provides the most symptom relief and to help reduce unnecessary antibiotic use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
amoxicillin/clavulanate (Augmentin) and budesonide nasal spray (Rhinocort)
What this could lead to
If successful, this could help doctors know which sinus infection patients truly need antibiotics and which can be treated with nasal sprays or rinses instead.
What could go wrong
This is a large but still early-phase study. Results may not apply to everyone, and some people may not improve with any of the treatments tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE SINUSITIS SINUS INFECTION

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Georgetown University Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • MedStar Health Research Institute

    NOT_YET_RECRUITING

    Hyattsville, Maryland, 20782, United States

  • Penn State College of Medicine

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

  • University of Washington

    RECRUITING

    Seattle, Washington, 98195, United States

  • University of Wisconsin-Madison

    RECRUITING

    Madison, Wisconsin, 53705, United States

  • Virginia Commonwealth University

    RECRUITING

    Richmond, Virginia, 23219, United States

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