Can nasal sprays replace antibiotics for sinus infections? major study aims to find out
NCT ID NCT06076304
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether antibiotics, nasal steroids, or nasal irrigation work best for treating sinus infections. About 3,720 adults with acute sinusitis will be randomly assigned to one of these treatments or a placebo. The goal is to see which approach provides the most symptom relief and to help reduce unnecessary antibiotic use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
amoxicillin/clavulanate (Augmentin) and budesonide nasal spray (Rhinocort)
What this could lead to
If successful, this could help doctors know which sinus infection patients truly need antibiotics and which can be treated with nasal sprays or rinses instead.
What could go wrong
This is a large but still early-phase study. Results may not apply to everyone, and some people may not improve with any of the treatments tested.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Georgetown University Medical Center
RECRUITINGWashington D.C., District of Columbia, 20007, United States
Contact
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MedStar Health Research Institute
NOT_YET_RECRUITINGHyattsville, Maryland, 20782, United States
Contact
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Penn State College of Medicine
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
Contact
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University of Wisconsin-Madison
RECRUITINGMadison, Wisconsin, 53705, United States
Contact
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23219, United States
Contact