New drug raphamin aims to speed relief from sinus infection symptoms

NCT ID NCT06901297

Recruiting now Symptom relief Sponsor: Materia Medica Holding Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether the drug Raphamin can quickly improve symptoms of acute rhinosinusitis (sinus infection) in adults. About 552 participants will receive either Raphamin or a placebo for a few days. The main goal is to see if more people feel much better by day 4 of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Raphamin (MMH-407)

What this could lead to

If it works, this could provide a new treatment option to relieve sinus infection symptoms more quickly.

What could go wrong

This is a Phase 3 trial, but results may not show a clear benefit over placebo. The condition often improves on its own, so the added value of Raphamin is uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Rhinosinusitis sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHINOSINUSITIS RHINOSINUSITIS ACUTE

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Aramil city hospital
ACTIVE_NOT_RECRUITING

Aramil, 624002, Russia
Baltic Federal University named after Immanuel Kant
RECRUITING

Kaliningrad, 236016, Russia

Contact

Contact
Bashkir State Medical University/Department of Internal Medicine
COMPLETED

Ufa, 450008, Russia
City Pokrovskaya Hospital
ACTIVE_NOT_RECRUITING

Saint Petersburg, 199106, Russia
City Polyclinic # 106
COMPLETED

Saint Petersburg, 198328, Russia
City Polyclinic # 109
ACTIVE_NOT_RECRUITING

Saint Petersburg, 192283, Russia
City Polyclinic # 2 of the Moscow City Department of Health
RECRUITING

Moscow, 117556, Russia

Contact

Contact
City Polyclinic # 34
COMPLETED

Saint Petersburg, 197198, Russia
City Polyclinic # 44
COMPLETED

Saint Petersburg, 192071, Russia
Clinical Hospital # 2
ACTIVE_NOT_RECRUITING

Yaroslavl, 150030, Russia
First Moscow State Medical University named after I.M. Sechenov/Department of Ear, Nose and Throat Diseases
COMPLETED

Moscow, 119991, Russia
First Saint Petersburg State Medical University named after I.P. Pavlov/Department of Otolaryngology with clinic
COMPLETED

Saint Petersburg, 197022, Russia
Gatchina Clinical Interdistrict Hospital
COMPLETED

Gatchina, Russia
Institute of Experimental Medicine
COMPLETED

Saint Petersburg, 197376, Russia
Kazan State Medical University/Department of Infectious Diseases
COMPLETED

Kazan', 420012, Russia
Kuban State Medical University/Department of Infectious Diseases and Phthisiopulmonology
TERMINATED

Krasnodar, 350063, Russia
LLC "4D Ultrasound Clinic"
NOT_YET_RECRUITING

Pyatigorsk, 357502, Russia

Contact

Contact
LLC "Clinical and Diagnostic Center "Mediclinic"
NOT_YET_RECRUITING

Penza, 440071, Russia

Contact

Contact
LLC "Dr. Bogorodskaya's Clinic of Modern Medicine"
ACTIVE_NOT_RECRUITING

Yaroslavl, 150001, Russia
LLC "Energy of Health"
COMPLETED

Saint Petersburg, 194156, Russia
LLC "Medical center "Reavita Med SPb"
COMPLETED

Saint Petersburg, 194354, Russia
LLC "Medical center for diagnostics and prevention plus"
RECRUITING

Yaroslavl, 150040, Russia

Contact

Contact
LLC "Medical services"
ACTIVE_NOT_RECRUITING

Saint Petersburg, 194356, Russia
LLC "Meili"
ACTIVE_NOT_RECRUITING

Saint Petersburg, 199406, Russia
LLC "Otolaryngology Consultation Center"
ACTIVE_NOT_RECRUITING

Rostov-on-Don, 344000, Russia
LLC "Our Health"
NOT_YET_RECRUITING

Saint Petersburg, 195272, Russia

Contact

Contact
LLC "Persona Group of Companies"
COMPLETED

Nizhny Novgorod, 603155, Russia
LLC "Professor's Clinic"
COMPLETED

Perm, 614070, Russia
LLC "Scientific Medical Center of General Therapy and Pharmacology"
ACTIVE_NOT_RECRUITING

Stavropol, 355000, Russia
LLC "Uromed"
COMPLETED

Smolensk, 214031, Russia
LLC "Zvezdnaya Clinic"
COMPLETED

Saint Petersburg, 196158, Russia
Medical University "Reaviz"
ACTIVE_NOT_RECRUITING

Samara, 443001, Russia
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
ACTIVE_NOT_RECRUITING

Moscow, 129110, Russia
National Medical Research Center of Otolaryngology
RECRUITING

Moscow, 123182, Russia

Contact

Contact
North-West State Medical University named after I.I. Mechnikov/Department of Otolaryngology
ACTIVE_NOT_RECRUITING

Saint Petersburg, 191015, Russia
Novosibirsk State Medical University/Department of Otolaryngology
COMPLETED

Novosibirsk, 630091, Russia
Rostov Central District Hospital
COMPLETED

Rostov-on-Don, 152155, Russia
Rostov-on-Don City Hospital of Emergency Medical Care
ACTIVE_NOT_RECRUITING

Rostov-on-Don, 344068, Russia
Russian University of Medicine/Department of Otolaryngology
COMPLETED

Moscow, 127006, Russia
Samara State Medical University/Department of Otolaryngology
COMPLETED

Samara, 443099, Russia
Saratov State Medical University named after V.I. Razumovsky/Department of Faculty Therapy
ACTIVE_NOT_RECRUITING

Saratov, 410012, Russia
St. Petersburg Research Institute of Phthisiopulmonology
ACTIVE_NOT_RECRUITING

Saint Petersburg, 191036, Russia
Ulyanovsk Regional Clinical Hospital
COMPLETED

Ulyanovsk, 432017, Russia
Ural State Medical University/Department of Surgical Dentistry, Otorhinolaryngology and Maxillofacial Surgery
WITHDRAWN

Yekaterinburg, 620028, Russia