New nasal spray aims to ease sinus troubles in teens
NCT ID NCT06850805
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a nasal spray called OPN-375 can reduce symptoms of chronic sinusitis (like stuffy nose, discharge, and facial pain) in adolescents aged 12 to 17. About 84 teens will receive either the spray or a placebo twice daily for 12 weeks. The main goal is to see if symptoms improve after 4 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
OPN-375 (fluticasone propionate) nasal spray
What this could lead to
If it works, this could provide a new treatment option to ease sinus symptoms like congestion and facial pain in teenagers.
What could go wrong
This is a mid-stage trial with only 84 participants, so results may not apply to everyone. The treatment may not work better than a placebo.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHRONIC RHINOSINUSITIS WITHOUT NASAL POLYPS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Email: •••••@•••••
Locations
-
Alamo ENT Associates
RECRUITINGSan Antonio, Texas, 78258, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Allergy, Asthma and Clinical Research Center
RECRUITINGOklahoma City, Oklahoma, 73120, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Breathe Clear Institute
RECRUITINGTorrance, California, 90503, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Carolina ENT Clinic/CENTRI Inc.
RECRUITINGOrangeburg, South Carolina, 29118, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Centers for Advanced ENT Care
RECRUITINGTowson, Maryland, 21204, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Charleston ENT & Allergy
RECRUITINGNorth Charleston, South Carolina, 29414, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Children's Healthcare of Atlanta
NOT_YET_RECRUITINGAtlanta, Georgia, 30329, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Children's Hospital of Orange County
RECRUITINGOrange, California, 92868, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Colorado ENT & Allergy
RECRUITINGColorado Springs, Colorado, 80909, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
DaVinci Research, LLC
RECRUITINGSacramento, California, 95661, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
EVMS at Old Dominion University
NOT_YET_RECRUITINGNorfolk, Virginia, 23507, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Kentuckiana ENT
RECRUITINGLouisville, Kentucky, 40205, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Orion Clinical Research
RECRUITINGAustin, Texas, 78759, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
STAAMP Research
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
San Tan Allergy & Asthma
WITHDRAWNGilbert, Arizona, 85214, United States
-
Southern Illinois University School of Medicine
RECRUITINGSpringfield, Illinois, 62702, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Missouri Medical Center
NOT_YET_RECRUITINGColumbia, Missouri, 65212, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Utah
NOT_YET_RECRUITINGSalt Lake City, Utah, 84112, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Vital Prospects Clinical Research Institute
RECRUITINGTulsa, Oklahoma, 74136, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••