New nasal spray aims to ease sinus troubles in teens

NCT ID NCT06850805

Recruiting now Symptom relief Sponsor: Optinose US Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a nasal spray called OPN-375 can reduce symptoms of chronic sinusitis (like stuffy nose, discharge, and facial pain) in adolescents aged 12 to 17. About 84 teens will receive either the spray or a placebo twice daily for 12 weeks. The main goal is to see if symptoms improve after 4 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: OPN-375 (fluticasone propionate) nasal spray
What this could lead to: If it works, this could provide a new treatment option to ease sinus symptoms like congestion and facial pain in teenagers.
What could go wrong: This is a mid-stage trial with only 84 participants, so results may not apply to everyone. The treatment may not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITHOUT NASAL POLYPS

Contacts and locations

Locations

Alamo ENT Associates
RECRUITING

San Antonio, Texas, 78258, United States
Allergy, Asthma and Clinical Research Center
RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Breathe Clear Institute
RECRUITING

Torrance, California, 90503, United States
Carolina ENT Clinic/CENTRI Inc.
RECRUITING

Orangeburg, South Carolina, 29118, United States
Centers for Advanced ENT Care
RECRUITING

Towson, Maryland, 21204, United States
Charleston ENT & Allergy
RECRUITING

North Charleston, South Carolina, 29414, United States
Children's Healthcare of Atlanta
NOT_YET_RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States
Colorado ENT & Allergy
RECRUITING

Colorado Springs, Colorado, 80909, United States
DaVinci Research, LLC
RECRUITING

Sacramento, California, 95661, United States
EVMS at Old Dominion University
NOT_YET_RECRUITING

Norfolk, Virginia, 23507, United States
Kentuckiana ENT
RECRUITING

Louisville, Kentucky, 40205, United States
Orion Clinical Research
RECRUITING

Austin, Texas, 78759, United States
STAAMP Research
RECRUITING

San Antonio, Texas, 78229, United States
San Tan Allergy & Asthma
WITHDRAWN

Gilbert, Arizona, 85214, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
University of Missouri Medical Center
NOT_YET_RECRUITING

Columbia, Missouri, 65212, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Utah
NOT_YET_RECRUITING

Salt Lake City, Utah, 84112, United States
Vital Prospects Clinical Research Institute
RECRUITING

Tulsa, Oklahoma, 74136, United States

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