Experimental antibody aims to stabilize blood pressure in sepsis patients

NCT ID NCT06608901

Completed Disease control Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an experimental drug called REGN7544 in 76 adults hospitalized with sepsis and low blood pressure. The drug is an antibody designed to help raise blood pressure and reduce the need for standard medications. Researchers measured safety, blood pressure changes, and total vasopressor use during the hospital stay.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: REGN7544 (an experimental antibody)
What this could lead to: If it works, this could lead to a new treatment to stabilize blood pressure in sepsis patients, reducing the need for standard vasopressors.
What could go wrong: This is a small, early Phase 2 trial with only 76 participants. The drug may not improve outcomes or could cause side effects. Results may not apply to all sepsis patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEPSIS-INDUCED HYPOTENSION

Contacts and locations

Show contact details

Locations

Atrium Health

Winston-Salem, North Carolina, 27157, United States
Bellevue Hospital

New York, New York, 10016, United States
CHU Dupuytren

Limoges, New Aquitaine, 87042, France
CHU Nantes

Nantes, 44093, France
CHU de Reims Hopital Robert Debre

Reims, 51100, France
Centre Hospitalier Departemental (CHD) Vendee

La Roche-sur-Yon, Vendee, 85925, France
Centre Hospitalier Le Mans

Le Mans, Pays de la Loire Region, 72037, France
Centre Hospitalier Regional Universaitaire de Tours (CHRU de Tours)

Tours, Centre-Val de Loire, 37000, France
Centre Hospitalier Universitaire Angers

Angers, 49933, France
Centre Hospitalier Universitaire d'Orleans

Orléans, 45064, France
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Emory University Hospital

Atlanta, Georgia, 30322, United States
Harvard Medical School - Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Hopital Cochin

Paris, Île-de-France Region, 75014, France
Hopital Nord Franche Comte

Trévenans, 90400, France
Hopitaux Universitaires de Strasbourg

Strasbourg, 67091, France
Intermountain Medical Center - Murray (Pulmonary Medicine)

Murray, Utah, 84107, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
MUSC SCTR Research Nexus Clinic and Lab

Charleston, South Carolina, 29425, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center - Weiler Hospital

The Bronx, New York, 10461, United States
New York University Langone Health Brooklyn Hospital

Brooklyn, New York, 11220, United States
New York University Langone Health Tisch-Kimmel Hospital

New York, New York, 10016, United States
Paris-Saclay University Hospitals

Le Kremlin-Bicêtre, 94270, France
Raymond Poincare University Hospital

Garches, 92380, France
University of Arizona

Tucson, Arizona, 85724, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Yale University

New Haven, Connecticut, 06510, United States