New antibody shows promise in reducing blood pressure meds for sepsis patients

NCT ID NCT06608901

First seen Nov 01, 2025 · Last updated May 25, 2026 · Updated 30 times

Summary

This study tested an experimental drug called REGN7544 in 76 adults hospitalized with sepsis and low blood pressure. The goal was to see if the drug could safely reduce the need for standard blood pressure medications (vasopressors). Researchers measured how much vasopressor patients needed and monitored side effects. The drug is not a cure but aims to better control blood pressure during sepsis.

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Contacts and locations

Locations

  • Atrium Health

    Winston-Salem, North Carolina, 27157, United States

  • Bellevue Hospital

    New York, New York, 10016, United States

  • CHU Dupuytren

    Limoges, New Aquitaine, 87042, France

  • CHU Nantes

    Nantes, 44093, France

  • CHU de Reims Hopital Robert Debre

    Reims, 51100, France

  • Centre Hospitalier Departemental (CHD) Vendee

    La Roche-sur-Yon, Vendee, 85925, France

  • Centre Hospitalier Le Mans

    Le Mans, Pays de la Loire Region, 72037, France

  • Centre Hospitalier Regional Universaitaire de Tours (CHRU de Tours)

    Tours, Centre-Val de Loire, 37000, France

  • Centre Hospitalier Universitaire Angers

    Angers, 49933, France

  • Centre Hospitalier Universitaire d'Orleans

    Orléans, 45064, France

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Harvard Medical School - Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Hopital Cochin

    Paris, Île-de-France Region, 75014, France

  • Hopital Nord Franche Comte

    Trévenans, 90400, France

  • Hopitaux Universitaires de Strasbourg

    Strasbourg, 67091, France

  • Intermountain Medical Center - Murray (Pulmonary Medicine)

    Murray, Utah, 84107, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21287, United States

  • MUSC SCTR Research Nexus Clinic and Lab

    Charleston, South Carolina, 29425, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Montefiore Medical Center - Moses Campus

    The Bronx, New York, 10467, United States

  • Montefiore Medical Center - Weiler Hospital

    The Bronx, New York, 10461, United States

  • New York University Langone Health Brooklyn Hospital

    Brooklyn, New York, 11220, United States

  • New York University Langone Health Tisch-Kimmel Hospital

    New York, New York, 10016, United States

  • Paris-Saclay University Hospitals

    Le Kremlin-Bicêtre, 94270, France

  • Raymond Poincare University Hospital

    Garches, 92380, France

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Yale University

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.