Could a common blood pressure drug improve major surgery outcomes?
NCT ID NCT05276596
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving norepinephrine early during major abdominal surgery could prevent drops in blood pressure and reduce organ problems afterward. 500 adults aged 50 and older took part. One group received norepinephrine early, while the other received the standard drug ephedrine. The main goal was to see if the early norepinephrine group had fewer complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
norepinephrine (noradrenaline)
What this could lead to
If it works, this could point toward a better way to manage blood pressure during major abdominal surgery, potentially reducing complications.
What could go wrong
This is a completed phase 3 trial, but results are not yet widely reported. The benefit over standard care (ephedrine) is unproven, and norepinephrine can have side effects like heart rhythm problems.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Amiens
Amiens, 80480, France