Could a common blood pressure drug improve major surgery outcomes?

NCT ID NCT05276596

Completed Disease control Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving norepinephrine early during major abdominal surgery could prevent drops in blood pressure and reduce organ problems afterward. 500 adults aged 50 and older took part. One group received norepinephrine early, while the other received the standard drug ephedrine. The main goal was to see if the early norepinephrine group had fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine (noradrenaline)
What this could lead to: If it works, this could point toward a better way to manage blood pressure during major abdominal surgery, potentially reducing complications.
What could go wrong: This is a completed phase 3 trial, but results are not yet widely reported. The benefit over standard care (ephedrine) is unproven, and norepinephrine can have side effects like heart rhythm problems.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANESTHESIOLOGY HYPOTENSION MAJOR ABDOMINAL SURGERY NOREPINEPHRINE

Contacts and locations

Locations

CHU Amiens

Amiens, 80480, France

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